SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mm1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
5 / 12 VAL A 139
GLY A 143
LEU A  98
GLY A 136
MET A  96
None
None
PGE  A 302 ( 3.6A)
None
PGE  A 302 ( 3.3A)
1.21A 1fduC-4mm1A:
undetectable
1fduC-4mm1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
4 / 6 LEU A 126
LEU A  21
ILE A  76
GLU A 124
None
0.94A 1mt1A-4mm1A:
undetectable
1mt1F-4mm1A:
undetectable
1mt1A-4mm1A:
12.55
1mt1F-4mm1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
4 / 6 ILE A  76
GLU A 124
LEU A 126
LEU A  21
None
0.96A 1mt1B-4mm1A:
undetectable
1mt1C-4mm1A:
undetectable
1mt1B-4mm1A:
19.83
1mt1C-4mm1A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
4 / 7 LEU A 126
LEU A  21
ILE A  76
GLU A 124
None
0.94A 1n13I-4mm1A:
undetectable
1n13L-4mm1A:
undetectable
1n13I-4mm1A:
12.55
1n13L-4mm1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
5 / 12 TYR A 105
ALA A 125
ILE A  93
ALA A 116
LEU A 113
None
1.24A 1udtA-4mm1A:
undetectable
1udtA-4mm1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
4 / 7 LEU A 126
LEU A  21
ILE A  76
GLU A 124
None
0.98A 2qqdA-4mm1A:
undetectable
2qqdE-4mm1A:
undetectable
2qqdA-4mm1A:
12.96
2qqdE-4mm1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
3 / 3 GLY A 176
GLY A 140
GLY A 136
1GP  A 301 ( 4.2A)
None
None
0.38A 3bogC-4mm1A:
undetectable
3bogC-4mm1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
3 / 3 GLY A 176
GLY A 140
GLY A 136
1GP  A 301 ( 4.2A)
None
None
0.40A 3bogD-4mm1A:
undetectable
3bogD-4mm1A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
4 / 8 PRO A 153
ALA A 157
ALA A 160
GLU A 186
None
0.81A 3dtuC-4mm1A:
undetectable
3dtuD-4mm1A:
undetectable
3dtuC-4mm1A:
17.14
3dtuD-4mm1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
4 / 4 VAL A   6
PHE A  94
PHE A  95
VAL A 118
None
None
PGE  A 302 (-3.7A)
None
1.35A 3rv5C-4mm1A:
undetectable
3rv5D-4mm1A:
undetectable
3rv5C-4mm1A:
19.40
3rv5D-4mm1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobac
ter
thermautotrophic
us)
3 / 3 ASP A  57
ARG A  88
ARG A  66
None
0.95A 4x5iA-4mm1A:
undetectable
4x5iA-4mm1A:
20.78