SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 ALA A 378
PHE A 261
LEU A 264
ILE A 272
TYR A 248
None
1.05A 1cd2A-4mmoA:
undetectable
1cd2A-4mmoA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 11 SER A 406
GLY A 403
LEU A 167
TYR A 367
HIS A 426
None
1.38A 1iolA-4mmoA:
undetectable
1iolA-4mmoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 11 PHE A 386
TYR A  69
VAL A  53
THR A  48
ILE A 148
None
1.09A 1phgA-4mmoA:
undetectable
1phgA-4mmoA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 TYR A 405
ILE A 424
VAL A 366
ALA A 363
LEU A 167
None
1.34A 1udtA-4mmoA:
undetectable
1udtA-4mmoA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.76A 1v7zA-4mmoA:
2.5
1v7zA-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.77A 1v7zB-4mmoA:
2.5
1v7zB-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.78A 1v7zC-4mmoA:
2.6
1v7zC-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.77A 1v7zD-4mmoA:
2.8
1v7zD-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.77A 1v7zE-4mmoA:
2.9
1v7zE-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.77A 1v7zF-4mmoA:
2.9
1v7zF-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
3 / 3 MET A 359
ASN A  70
GLN A 381
None
0.99A 1xoqB-4mmoA:
undetectable
1xoqB-4mmoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 VAL A 225
ILE A 215
LEU A 308
LEU A 329
ILE A 227
None
1.13A 2w3vA-4mmoA:
undetectable
2w3vA-4mmoA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 TYR A  55
VAL A  54
TYR A 133
VAL A  41
None
1.26A 2y05A-4mmoA:
undetectable
2y05B-4mmoA:
undetectable
2y05A-4mmoA:
22.73
2y05B-4mmoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 GLY A 101
ASP A 104
LEU A  12
LEU A  31
GLU A 138
None
ZN  A 501 (-2.5A)
None
None
ZN  A 501 ( 4.5A)
1.09A 2zw9B-4mmoA:
undetectable
2zw9B-4mmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.80A 3a6jA-4mmoA:
3.1
3a6jA-4mmoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 7 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.81A 3a6jB-4mmoA:
2.7
3a6jB-4mmoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.81A 3a6jC-4mmoA:
2.5
3a6jC-4mmoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.81A 3a6jE-4mmoA:
2.9
3a6jE-4mmoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 GLU A 163
HIS A  71
ASP A 104
GLU A 138
ZN  A 501 (-1.7A)
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 ( 4.5A)
0.81A 3a6jF-4mmoA:
2.8
3a6jF-4mmoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 ILE A 175
GLN A 381
ASN A 105
LEU A 132
ILE A  68
None
None
ZN  A 501 ( 4.9A)
None
None
1.29A 3em0B-4mmoA:
undetectable
3em0B-4mmoA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 4 PRO A 207
TYR A 191
GLY A 192
THR A 193
None
1.22A 3ib0A-4mmoA:
undetectable
3ib0A-4mmoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 THR A  34
LEU A  39
ALA A  56
ALA A  43
None
0.86A 3ns1L-4mmoA:
1.1
3ns1L-4mmoA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 10 TYR A  98
ILE A  97
ASN A 407
TYR A 405
ILE A 415
None
1.44A 3u6tA-4mmoA:
undetectable
3u6tA-4mmoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 8 LEU A 109
PHE A  11
THR A  34
VAL A  35
None
0.92A 3uniB-4mmoA:
undetectable
3uniB-4mmoA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
3 / 3 GLN A 381
ASP A 104
GLN A  75
None
ZN  A 501 (-2.5A)
None
0.75A 4aztA-4mmoA:
undetectable
4aztA-4mmoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 5 ALA A  62
ILE A  58
LEU A 125
ASN A 128
None
1.16A 4g19A-4mmoA:
undetectable
4g19A-4mmoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 7 TYR A  69
GLU A 138
GLU A 134
GLU A 344
None
ZN  A 501 ( 4.5A)
None
None
1.15A 4mi4A-4mmoA:
undetectable
4mi4C-4mmoA:
undetectable
4mi4A-4mmoA:
19.41
4mi4C-4mmoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 5 TYR A  98
ASN A 407
TYR A 405
ILE A 415
None
1.16A 4o0oA-4mmoA:
undetectable
4o0oA-4mmoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
6 / 11 HIS A  71
ASP A 104
GLU A 137
GLU A 138
GLU A 163
GLY A 379
ZN  A 501 (-3.2A)
ZN  A 501 (-2.5A)
ZN  A 501 (-3.4A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-1.7A)
SO4  A 502 (-3.5A)
0.44A 4pqaA-4mmoA:
35.6
4pqaA-4mmoA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 5 LEU A 167
TYR A 367
ALA A 423
ILE A 399
None
0.82A 4y03B-4mmoA:
undetectable
4y03B-4mmoA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 LEU A 131
ILE A  68
LEU A  66
ILE A 161
ILE A 399
None
0.65A 4y0rA-4mmoA:
undetectable
4y0rA-4mmoA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 VAL A  54
ILE A  68
LEU A 113
LEU A  39
VAL A  35
None
1.27A 5im2A-4mmoA:
undetectable
5im2A-4mmoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 9 ILE A 399
TYR A 367
ILE A 175
PRO A 173
ALA A 165
None
1.09A 5mvmA-4mmoA:
undetectable
5mvmE-4mmoA:
undetectable
5mvmA-4mmoA:
11.86
5mvmE-4mmoA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
5 / 12 GLY A 178
PHE A 386
VAL A 387
ILE A 399
ALA A 165
None
0.94A 5n0xA-4mmoA:
undetectable
5n0xA-4mmoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 5 TYR A 405
TYR A 404
GLY A 403
GLY A 402
None
0.71A 5x7pA-4mmoA:
undetectable
5x7pA-4mmoA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 6 TYR A 405
TYR A 404
GLY A 403
GLY A 402
None
0.71A 5x7pB-4mmoA:
undetectable
5x7pB-4mmoA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 6 GLU A  46
LYS A 154
LEU A 155
LEU A 132
None
1.16A 5yvnA-4mmoA:
undetectable
5yvnA-4mmoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus)
4 / 5 ASP A 158
ILE A 161
PHE A 430
ASN A  61
None
1.25A 6a93B-4mmoA:
undetectable
6a93B-4mmoA:
21.94