SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 6 LEU A 108
LEU A 116
ILE A  75
GLU A  79
 None
 0.90A 1mt1A-4mmpA:
undetectable
1mt1F-4mmpA:
undetectable		 1mt1A-4mmpA:
16.04
1mt1F-4mmpA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 6 ILE A  75
GLU A  79
LEU A 108
LEU A 116
 None
 0.80A 1mt1B-4mmpA:
undetectable
1mt1C-4mmpA:
undetectable		 1mt1B-4mmpA:
13.64
1mt1C-4mmpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 7 ILE A  75
GLU A  79
LEU A 108
LEU A 116
 None
 0.92A 1mt1H-4mmpA:
undetectable
1mt1K-4mmpA:
undetectable		 1mt1H-4mmpA:
13.64
1mt1K-4mmpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		5 / 12 ASN A 126
ALA A 124
LEU A 219
THR A 193
PHE A 251
 None
 1.36A 2oaxC-4mmpA:
undetectable		 2oaxC-4mmpA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		5 / 12 ASN A 126
ALA A 124
LEU A 219
THR A 193
PHE A 251
 None
 1.42A 2oaxF-4mmpA:
undetectable		 2oaxF-4mmpA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 5 LEU A 228
PRO A 229
LEU A 232
ILE A  38
 None
 0.79A 2qd4A-4mmpA:
undetectable		 2qd4A-4mmpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		5 / 12 ILE A  89
ALA A  98
TYR A 125
VAL A 252
LEU A 213
 None
 1.33A 2rctA-4mmpA:
undetectable		 2rctA-4mmpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		5 / 9 SER A  95
ALA A  71
GLU A 302
GLY A 107
LEU A 108
 None
 1.24A 2v0mB-4mmpA:
undetectable		 2v0mB-4mmpA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 5 GLN A 130
THR A 131
THR A 155
LEU A 281
 None
 1.40A 2zj0A-4mmpA:
undetectable		 2zj0A-4mmpA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		5 / 12 ASN A 126
ALA A 124
LEU A 219
THR A 193
PHE A 251
 None
 1.33A 3vhuA-4mmpA:
undetectable		 3vhuA-4mmpA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 4 LEU A 228
PRO A 229
LEU A 232
ILE A  38
 None
 0.88A 4f4dB-4mmpA:
undetectable		 4f4dB-4mmpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 4 VAL A 123
ALA A 244
PHE A  92
THR A 248
 None
 1.48A 4z4fA-4mmpA:
undetectable		 4z4fA-4mmpA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 4 VAL A 123
ALA A 244
PHE A  92
THR A 248
 None
 1.48A 4z4hA-4mmpA:
undetectable		 4z4hA-4mmpA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 4 ASP A 215
ILE A  89
PRO A  90
LEU A 213
 None
 1.00A 6mkeB-4mmpA:
undetectable		 6mkeB-4mmpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4mmp SIALIC ACID BINDING
PROTEIN
(Pasteurella
multocida) 		4 / 4 ASP A 215
ILE A  89
PRO A  90
LEU A 213
 None
 0.99A 6mkeA-4mmpA:
undetectable		 6mkeA-4mmpA:
14.52