SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4mn0 BEROVIN
(Beroe
abyssicola) 		3 / 3 LYS A  90
ARG A 108
VAL A 109
 None
 1.11A 2r2vC-4mn0A:
undetectable
2r2vD-4mn0A:
undetectable		 2r2vC-4mn0A:
11.60
2r2vD-4mn0A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mn0 BEROVIN
(Beroe
abyssicola) 		5 / 12 PHE A 188
SER A 132
VAL A 136
PHE A 157
ALA A 156
 None
 1.28A 3u9fD-4mn0A:
undetectable
3u9fE-4mn0A:
undetectable		 3u9fD-4mn0A:
20.73
3u9fE-4mn0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mn0 BEROVIN
(Beroe
abyssicola) 		5 / 12 PHE A 188
SER A 132
VAL A 136
PHE A 157
ALA A 156
 None
 1.22A 3u9fG-4mn0A:
undetectable
3u9fH-4mn0A:
undetectable		 3u9fG-4mn0A:
20.73
3u9fH-4mn0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4mn0 BEROVIN
(Beroe
abyssicola) 		3 / 3 ARG A  66
MET A  79
ARG A  80
 None
 1.39A 3uvvA-4mn0A:
undetectable		 3uvvA-4mn0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4mn0 BEROVIN
(Beroe
abyssicola) 		4 / 6 ARG A 119
GLU A 122
TYR A  15
LEU A  16
 None
 1.38A 4twdF-4mn0A:
undetectable
4twdG-4mn0A:
undetectable		 4twdF-4mn0A:
19.56
4twdG-4mn0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4mn0 BEROVIN
(Beroe
abyssicola) 		5 / 9 PHE A 168
ALA A 164
PHE A 167
LEU A 179
VAL A 145
 None
 1.41A 4z69A-4mn0A:
2.8		 4z69A-4mn0A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4mn0 BEROVIN
(Beroe
abyssicola) 		5 / 12 GLY A  91
PHE A 110
VAL A  58
ASN A 107
TRP A 103
 None
 1.03A 5nz0A-4mn0A:
undetectable		 5nz0A-4mn0A:
22.73