SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4mn5 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		4 / 4 ILE A 360
SER A 347
ASP A 274
ASP A 365
 None
None
ZN  A 401 (-2.1A)
None
 1.37A 4krhB-4mn5A:
undetectable		 4krhB-4mn5A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mn5 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		5 / 12 ARG A 343
PHE A 346
THR A 279
ILE A 277
LEU A 312
 None
 0.88A 4m6kA-4mn5A:
undetectable		 4m6kA-4mn5A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4mn5 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		5 / 11 ASP A 280
ILE A 323
ILE A 349
ILE A 303
ILE A 304
 None
 1.15A 5hw8A-4mn5A:
undetectable
5hw8D-4mn5A:
undetectable		 5hw8A-4mn5A:
21.74
5hw8D-4mn5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4mn5 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		4 / 6 TYR A 359
ARG A 281
ASP A 280
GLY A 283
 None
 0.83A 5mraA-4mn5A:
undetectable
5mraB-4mn5A:
undetectable		 5mraA-4mn5A:
20.97
5mraB-4mn5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4mn5 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		3 / 3 HIS A 271
ASP A 274
HIS A 364
 ZN  A 401 (-3.3A)
ZN  A 401 (-2.1A)
ZN  A 401 (-3.3A)
 0.77A 5oexA-4mn5A:
undetectable		 5oexA-4mn5A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4mn5 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		4 / 4 ILE A 277
LEU A 334
HIS A 364
ALA A 342
 None
None
ZN  A 401 (-3.3A)
None
 0.98A 6ck2C-4mn5A:
undetectable
6ck2D-4mn5A:
undetectable		 6ck2C-4mn5A:
9.38
6ck2D-4mn5A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4mn5 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		5 / 9 LEU A 293
VAL A 288
SER A 310
LEU A 312
ILE A 277
 None
 1.04A 6fdyU-4mn5A:
undetectable		 6fdyU-4mn5A:
20.00