SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mn6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4mn6 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		5 / 11 GLY A 275
ALA A 292
ILE A 303
VAL A 311
ILE A 287
 None
 0.91A 3ebzB-4mn6A:
undetectable		 3ebzB-4mn6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4mn6 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		3 / 3 ASP A 274
VAL A 288
ASN A 345
 ZN  A 401 (-2.1A)
None
None
 0.61A 4lmnA-4mn6A:
undetectable		 4lmnA-4mn6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4mn6 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		4 / 6 TYR A 359
ARG A 281
ASP A 280
GLY A 283
 None
 0.87A 5mraA-4mn6A:
undetectable
5mraB-4mn6A:
undetectable		 5mraA-4mn6A:
23.38
5mraB-4mn6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4mn6 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		3 / 3 HIS A 271
ASP A 274
HIS A 364
 ZN  A 401 (-3.1A)
ZN  A 401 (-2.1A)
ZN  A 401 (-2.8A)
 0.79A 5oexA-4mn6A:
undetectable		 5oexA-4mn6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4mn6 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		5 / 10 LEU A 314
ILE A 277
ALA A 342
LEU A 334
GLU A 317
 None
 1.23A 5y7pG-4mn6A:
undetectable		 5y7pG-4mn6A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4mn6 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		5 / 9 VAL A 311
LEU A 312
GLY A 275
LEU A 363
VAL A 288
 None
 1.30A 6czmA-4mn6A:
undetectable
6czmB-4mn6A:
undetectable		 6czmA-4mn6A:
16.67
6czmB-4mn6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4mn6 SENSOR PROTEIN
KINASE WALK
(Staphylococcus
aureus) 		5 / 9 LEU A 293
VAL A 288
SER A 310
LEU A 312
ILE A 277
 None
 1.01A 6fdyU-4mn6A:
undetectable		 6fdyU-4mn6A:
16.48