SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 TYR A 177
GLY A 201
GLY A 174
SER A 224
 None
 0.97A 1eswA-4mn8A:
undetectable		 1eswA-4mn8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 LEU A 415
ASN A 394
VAL A 367
GLY A 368
LEU A 376
 None
 1.45A 1fkoA-4mn8A:
undetectable		 1fkoA-4mn8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 LEU A 271
LEU A 269
ILE A 295
GLU A 283
LEU A 287
 None
 1.13A 1wopA-4mn8A:
undetectable		 1wopA-4mn8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 5 LEU A 734
GLY A 712
HIS A 688
ILE A 689
 None
 0.82A 1xf1A-4mn8A:
undetectable		 1xf1A-4mn8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 734
GLY A 712
HIS A 688
ILE A 689
 None
 0.80A 1xf1B-4mn8A:
undetectable		 1xf1B-4mn8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 669
SER A 607
SER A 681
PHE A 680
ILE A 641
 None
None
NAG  A 903 (-2.5A)
None
None
 1.27A 1xotA-4mn8A:
undetectable		 1xotA-4mn8A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.06A 1z11A-4mn8A:
undetectable		 1z11A-4mn8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.03A 1z11B-4mn8A:
undetectable		 1z11B-4mn8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.10A 1z11C-4mn8A:
undetectable		 1z11C-4mn8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.03A 1z11D-4mn8A:
undetectable		 1z11D-4mn8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 9 LEU A 324
LEU A 300
ILE A 295
LEU A 308
ILE A 304
 None
 1.24A 2f7aB-4mn8A:
undetectable		 2f7aB-4mn8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4mn8 FLG22
LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(;
Arabidopsis
thaliana) 		5 / 12 ASP A 150
GLY A 174
ASP A 176
GLY C  70
ASP A 220
 None
 1.34A 2fqyA-4mn8A:
undetectable		 2fqyA-4mn8A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.18A 2hrcA-4mn8A:
undetectable		 2hrcA-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.24A 2hrcB-4mn8A:
undetectable		 2hrcB-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ALA A 282
GLY A 285
GLY A 318
LEU A 317
LEU A 341
 None
 0.99A 2hw2A-4mn8A:
undetectable		 2hw2A-4mn8A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 532
MET A 534
LEU A 558
MET A 523
 None
 0.97A 2kuhA-4mn8A:
undetectable		 2kuhA-4mn8A:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 558
MET A 534
LEU A 539
MET A 547
 None
 0.97A 2kuhA-4mn8A:
undetectable		 2kuhA-4mn8A:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ALA A  91
LEU A  95
LEU A  34
PHE A  37
LEU A  79
 None
 1.13A 2oipE-4mn8A:
undetectable		 2oipE-4mn8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 LEU A 413
PHE A 428
ILE A 400
PHE A 443
 None
 0.85A 2opxA-4mn8A:
undetectable		 2opxA-4mn8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 359
LEU A 362
LEU A 386
ILE A 332
PRO A 401
 None
 1.05A 2pnjA-4mn8A:
undetectable		 2pnjA-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.04A 2po5A-4mn8A:
undetectable		 2po5A-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.08A 2po7A-4mn8A:
undetectable		 2po7A-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.05A 2po7B-4mn8A:
undetectable		 2po7B-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 LEU A 223
LEU A 247
GLN A 268
LEU A 218
ASP A 220
 None
 1.25A 2q6hA-4mn8A:
undetectable		 2q6hA-4mn8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 ILE A  41
PRO A 113
LEU A 101
ILE A  92
 None
 0.92A 2q83B-4mn8A:
undetectable		 2q83B-4mn8A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 LEU A 223
LEU A 247
GLN A 268
LEU A 218
ASP A 220
 None
 1.25A 2qeiA-4mn8A:
undetectable		 2qeiA-4mn8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
 None
 1.41A 2vdyA-4mn8A:
undetectable		 2vdyA-4mn8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		3 / 3 SER A 726
GLU A 653
ASP A 605
 None
 0.82A 2zulA-4mn8A:
undetectable		 2zulA-4mn8A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ALA A 463
HIS A 417
SER A 512
TYR A 509
LEU A 484
 SO4  A 919 ( 4.7A)
None
SO4  A 916 (-2.3A)
None
None
 0.88A 3bxoA-4mn8A:
undetectable		 3bxoA-4mn8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		3 / 3 SER A 726
GLU A 653
ASP A 605
 None
 0.78A 3dmhA-4mn8A:
undetectable		 3dmhA-4mn8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 223
LEU A 247
GLN A 268
LEU A 218
ASP A 220
 None
 1.24A 3gwuA-4mn8A:
undetectable		 3gwuA-4mn8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ASN A 441
ASN A 418
VAL A 367
PHE A 352
LEU A 389
 None
 1.32A 3hkuA-4mn8A:
undetectable		 3hkuA-4mn8A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4mn8 BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 8 LEU A 577
THR A 578
GLY B  76
ALA B  78
 None
SO4  A 911 (-3.6A)
SO4  B 302 (-3.2A)
None
 0.77A 3jusA-4mn8A:
undetectable		 3jusA-4mn8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4mn8 BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 8 LEU A 577
THR A 578
GLY B  76
ALA B  78
 None
SO4  A 911 (-3.6A)
SO4  B 302 (-3.2A)
None
 0.77A 3jusA-4mn8A:
undetectable		 3jusA-4mn8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 ASN A 779
LEU A 776
LEU A 751
VAL A 767
ILE A 738
 None
 1.28A 3jw5A-4mn8A:
undetectable		 3jw5A-4mn8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 5 ILE A 700
MET A 650
ASN A 625
PHE A 694
 None
 1.23A 3octA-4mn8A:
undetectable		 3octA-4mn8A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 GLY A 663
GLY A 639
THR A 638
LEU A 660
ASN A 684
 None
 1.06A 3sglA-4mn8A:
undetectable		 3sglA-4mn8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 9 ARG A 387
LEU A 362
LEU A 389
ASN A 388
ILE A 356
 None
None
None
NAG  A 907 (-1.6A)
None
 1.29A 3wdmA-4mn8A:
undetectable		 3wdmA-4mn8A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
 None
 1.37A 4c49B-4mn8A:
undetectable		 4c49B-4mn8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
 None
 1.40A 4c49C-4mn8A:
undetectable		 4c49C-4mn8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 LEU A 386
SER A 320
LEU A 413
LEU A 376
ILE A 356
 None
 1.12A 4dm8A-4mn8A:
undetectable		 4dm8A-4mn8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mn8 BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU B 121
LEU B 145
LEU B 166
SER B 185
THR B 161
 None
 1.20A 4f4dB-4mn8B:
undetectable		 4f4dB-4mn8B:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 ASP A 393
ASP A 414
SER A 437
SER A 416
 None
 0.83A 4k7gB-4mn8A:
undetectable		 4k7gB-4mn8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 ASP A 414
SER A 437
HIS A 417
SER A 416
 None
 1.24A 4k7gB-4mn8A:
undetectable		 4k7gB-4mn8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 539
ASN A 537
MET A 547
LEU A 532
 None
 1.13A 4okbA-4mn8A:
undetectable		 4okbA-4mn8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 539
ASN A 537
MET A 547
LEU A 532
 None
 1.11A 4okxA-4mn8A:
undetectable		 4okxA-4mn8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 156
PHE A 175
ILE A 140
LEU A 149
THR A 181
 None
 1.19A 4qlgA-4mn8A:
undetectable		 4qlgA-4mn8A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ASN A 489
SER A 490
ILE A 447
PRO A 448
ASP A 450
 None
None
None
SO4  A 920 (-3.7A)
None
 1.32A 4uroD-4mn8A:
undetectable		 4uroD-4mn8A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
FLG22
(Arabidopsis
thaliana;
) 		4 / 5 GLY A 368
THR A 366
HIS A 392
GLY C  82
 None
None
None
SO4  C 101 (-3.3A)
 1.03A 4v20A-4mn8A:
undetectable		 4v20A-4mn8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		3 / 3 ASP A 176
GLY A 174
ASP A 150
 None
 0.55A 4xdtA-4mn8A:
undetectable		 4xdtA-4mn8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4mn8 FLG22
LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(;
Arabidopsis
thaliana) 		5 / 12 GLY A 493
LEU A 484
ILE C  85
GLY A 439
THR A 470
 None
 1.15A 4ze2A-4mn8A:
undetectable		 4ze2A-4mn8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4mn8 FLG22
LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(;
Arabidopsis
thaliana) 		4 / 6 ALA A 200
GLN C  65
SER C  75
ASP A 220
 None
 1.10A 5c6pA-4mn8A:
undetectable		 5c6pA-4mn8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 GLY A 663
SER A 662
PHE A 661
HIS A 688
LEU A 705
 None
 1.09A 5ergB-4mn8A:
undetectable		 5ergB-4mn8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 5 ARG A 707
SER A 731
SER A 730
SER A 681
 NAG  A 903 (-3.8A)
None
None
NAG  A 903 (-2.5A)
 1.11A 5hswA-4mn8A:
undetectable		 5hswA-4mn8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 685
PHE A 680
LEU A 630
ILE A 591
LEU A 619
 None
 1.36A 5ienA-4mn8A:
undetectable		 5ienA-4mn8A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 9 LEU A 776
ASN A 779
GLY A 736
ILE A 714
VAL A 762
 None
 1.16A 5kr2D-4mn8A:
undetectable		 5kr2D-4mn8A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 ILE A 164
ILE A 173
VAL A 160
ASN A 178
ASP A 176
 None
 1.25A 5lg3F-4mn8A:
undetectable		 5lg3F-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 ILE A 164
ILE A 173
VAL A 160
ASN A 178
ASP A 176
 None
 1.25A 5lg3G-4mn8A:
undetectable		 5lg3G-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 ILE A 164
ILE A 173
VAL A 160
ASN A 178
ASP A 176
 None
 1.25A 5lg3H-4mn8A:
undetectable		 5lg3H-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 9 ILE A 173
VAL A 160
ASN A 178
ASP A 176
 None
 1.04A 5lg3I-4mn8A:
undetectable		 5lg3I-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 LEU A  95
ALA A  91
ILE A 116
LEU A 119
 None
 1.05A 5te8A-4mn8A:
undetectable		 5te8A-4mn8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 PRO A 327
GLY A 350
GLY A 318
LEU A 338
LEU A 341
 None
 1.02A 5wwsA-4mn8A:
undetectable		 5wwsA-4mn8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.43A 6dlzB-4mn8A:
undetectable
6dlzC-4mn8A:
undetectable		 6dlzB-4mn8A:
6.72
6dlzC-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.43A 6dlzA-4mn8A:
undetectable
6dlzD-4mn8A:
undetectable		 6dlzA-4mn8A:
6.72
6dlzD-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 307
LEU A 269
LEU A 314
ILE A 260
GLY A 261
 None
 1.04A 6dm0B-4mn8A:
undetectable
6dm0C-4mn8A:
undetectable		 6dm0B-4mn8A:
6.72
6dm0C-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.43A 6dm1B-4mn8A:
undetectable
6dm1C-4mn8A:
undetectable		 6dm1B-4mn8A:
6.72
6dm1C-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.43A 6dm1A-4mn8A:
undetectable
6dm1D-4mn8A:
undetectable		 6dm1A-4mn8A:
6.72
6dm1D-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.42A 6dm2B-4mn8A:
undetectable
6dm2C-4mn8A:
undetectable		 6dm2B-4mn8A:
6.72
6dm2C-4mn8A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.42A 6dm2A-4mn8A:
undetectable
6dm2D-4mn8A:
undetectable		 6dm2A-4mn8A:
6.72
6dm2D-4mn8A:
6.72