SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mna'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 LEU A 395
SER A 373
THR A 349
VAL A 325
 None
 0.86A 1ictD-4mnaA:
undetectable		 1ictD-4mnaA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 LEU A 582
SER A 581
ASP A 557
PHE A 563
 None
 0.81A 1ismB-4mnaA:
undetectable		 1ismB-4mnaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		3 / 3 ASN A 370
ALA A 391
ASN A 418
 None
 0.81A 1n4fA-4mnaA:
undetectable		 1n4fA-4mnaA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 LEU A 271
LEU A 269
ILE A 295
GLU A 283
LEU A 287
 None
 1.20A 1wopA-4mnaA:
undetectable		 1wopA-4mnaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 5 LEU A 734
GLY A 712
HIS A 688
ILE A 689
 None
 0.85A 1xf1A-4mnaA:
undetectable		 1xf1A-4mnaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 734
GLY A 712
HIS A 688
ILE A 689
 None
 0.82A 1xf1B-4mnaA:
undetectable		 1xf1B-4mnaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 669
SER A 607
SER A 681
PHE A 680
ILE A 641
 None
NAG  A 902 (-2.9A)
NAG  A 901 (-2.8A)
None
None
 1.28A 1xotA-4mnaA:
undetectable		 1xotA-4mnaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.05A 1z11A-4mnaA:
undetectable		 1z11A-4mnaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.05A 1z11B-4mnaA:
undetectable		 1z11B-4mnaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.10A 1z11C-4mnaA:
undetectable		 1z11C-4mnaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 VAL A 693
ILE A 689
ILE A 641
LEU A 669
PHE A 680
 None
 1.03A 1z11D-4mnaA:
undetectable		 1z11D-4mnaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 ILE A 280
ARG A 294
THR A 342
LEU A 343
 None
None
ZN  A 907 ( 4.8A)
None
 1.00A 2einN-4mnaA:
undetectable
2einW-4mnaA:
undetectable		 2einN-4mnaA:
22.41
2einW-4mnaA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.19A 2hrcA-4mnaA:
undetectable		 2hrcA-4mnaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.23A 2hrcB-4mnaA:
undetectable		 2hrcB-4mnaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ALA A 282
GLY A 285
GLY A 318
LEU A 317
LEU A 341
 None
 1.05A 2hw2A-4mnaA:
undetectable		 2hw2A-4mnaA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 532
MET A 534
LEU A 558
MET A 523
 None
 0.92A 2kuhA-4mnaA:
undetectable		 2kuhA-4mnaA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 558
MET A 534
LEU A 539
MET A 547
 None
 0.91A 2kuhA-4mnaA:
undetectable		 2kuhA-4mnaA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 LEU A 413
PHE A 428
ILE A 400
PHE A 443
 None
 0.94A 2opxA-4mnaA:
undetectable		 2opxA-4mnaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.10A 2po5A-4mnaA:
undetectable		 2po5A-4mnaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.14A 2po7A-4mnaA:
undetectable		 2po7A-4mnaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.10A 2po7B-4mnaA:
undetectable		 2po7B-4mnaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
 None
None
None
NAG  A 902 (-2.9A)
None
 1.46A 2vdyA-4mnaA:
undetectable		 2vdyA-4mnaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 645
ILE A 641
VAL A 693
ILE A 689
PHE A 680
 None
 1.07A 3b2rA-4mnaA:
undetectable		 3b2rA-4mnaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 LEU A 645
ILE A 641
VAL A 693
ILE A 689
PHE A 680
 None
 1.07A 3b2rB-4mnaA:
undetectable		 3b2rB-4mnaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ALA A 463
HIS A 417
SER A 512
TYR A 509
LEU A 484
 None
 0.86A 3bxoA-4mnaA:
undetectable		 3bxoA-4mnaA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
 None
None
None
NAG  A 902 (-2.9A)
None
 1.41A 4c49B-4mnaA:
undetectable		 4c49B-4mnaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
 None
None
None
NAG  A 902 (-2.9A)
None
 1.46A 4c49C-4mnaA:
undetectable		 4c49C-4mnaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 LEU A 386
SER A 320
LEU A 413
LEU A 376
ILE A 356
 None
ZN  A 907 ( 4.1A)
None
None
None
 1.19A 4dm8A-4mnaA:
undetectable		 4dm8A-4mnaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 GLY A 318
PRO A 353
ILE A 356
LEU A 359
ILE A 332
 None
 1.10A 4dt8A-4mnaA:
undetectable		 4dt8A-4mnaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 4 LEU A  79
LEU A  88
GLN A  83
GLU A 249
 None
 1.13A 4i41A-4mnaA:
undetectable		 4i41A-4mnaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 ASP A 393
ASP A 414
SER A 437
SER A 416
 None
 0.88A 4k7gB-4mnaA:
undetectable		 4k7gB-4mnaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 ASP A 414
SER A 437
HIS A 417
SER A 416
 None
 1.23A 4k7gB-4mnaA:
undetectable		 4k7gB-4mnaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		3 / 3 SER A 536
ASP A 605
ASP A 655
 None
NAG  A 902 ( 4.6A)
NAG  A 902 (-3.8A)
 0.83A 4mwzA-4mnaA:
undetectable		 4mwzA-4mnaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 5 LEU A 529
ILE A 499
LEU A 510
LEU A 582
 None
 0.82A 4o8fA-4mnaA:
undetectable		 4o8fA-4mnaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 539
ASN A 537
MET A 547
LEU A 532
 None
 1.07A 4okbA-4mnaA:
undetectable		 4okbA-4mnaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 6 LEU A 539
ASN A 537
MET A 547
LEU A 532
 None
 1.07A 4okxA-4mnaA:
undetectable		 4okxA-4mnaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 319
LEU A 343
ASN A 346
SER A 390
LEU A 365
 None
None
None
ZN  A 905 (-3.5A)
None
 1.19A 5mwyA-4mnaA:
undetectable		 5mwyA-4mnaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.36A 6dlzB-4mnaA:
undetectable
6dlzC-4mnaA:
undetectable		 6dlzB-4mnaA:
7.51
6dlzC-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.36A 6dlzA-4mnaA:
undetectable
6dlzD-4mnaA:
undetectable		 6dlzA-4mnaA:
7.51
6dlzD-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 307
LEU A 269
LEU A 314
ILE A 260
GLY A 261
 None
 1.06A 6dm0B-4mnaA:
undetectable
6dm0C-4mnaA:
undetectable		 6dm0B-4mnaA:
7.51
6dm0C-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.36A 6dm1B-4mnaA:
undetectable
6dm1C-4mnaA:
undetectable		 6dm1B-4mnaA:
7.51
6dm1C-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 11 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.36A 6dm1A-4mnaA:
undetectable
6dm1D-4mnaA:
undetectable		 6dm1A-4mnaA:
7.51
6dm1D-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 SER A 597
LEU A 582
LEU A 577
ILE A 567
PRO A 592
 None
 1.35A 6dm2B-4mnaA:
undetectable
6dm2C-4mnaA:
undetectable		 6dm2B-4mnaA:
7.51
6dm2C-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 10 ILE A 567
PRO A 592
SER A 597
LEU A 582
LEU A 577
 None
 1.35A 6dm2A-4mnaA:
undetectable
6dm2D-4mnaA:
undetectable		 6dm2A-4mnaA:
7.51
6dm2D-4mnaA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		4 / 7 ILE A 280
ARG A 294
THR A 342
LEU A 343
 None
None
ZN  A 907 ( 4.8A)
None
 1.00A 6nmfA-4mnaA:
undetectable
6nmfJ-4mnaA:
undetectable		 6nmfA-4mnaA:
22.41
6nmfJ-4mnaA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 LEU A 319
ILE A 295
LEU A 252
ASP A 255
GLY A 278
 None
 1.17A 6qxsD-4mnaA:
undetectable		 6qxsD-4mnaA:
20.43