SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		3 / 4 VAL A 259
TRP A 267
TRP A  51
 None
 1.31A 1gmkC-4mniA:
undetectable
1gmkD-4mniA:
undetectable		 1gmkC-4mniA:
5.36
1gmkD-4mniA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 5 GLU A 263
LEU A 257
LEU A 260
LEU A 258
 None
 1.03A 1np1A-4mniA:
undetectable		 1np1A-4mniA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 TYR A 229
PHE A 228
PHE A 177
VAL A 184
THR A 186
 None
 1.32A 1q23F-4mniA:
undetectable		 1q23F-4mniA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 7 TYR A 270
GLU A 274
TYR A  44
ILE A 211
 None
None
173  A 401 (-4.8A)
None
 1.15A 1tuvA-4mniA:
undetectable		 1tuvA-4mniA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.05A 1v54A-4mniA:
undetectable
1v54J-4mniA:
undetectable		 1v54A-4mniA:
20.38
1v54J-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ASN A  56
LEU A 260
MET A  90
LEU A 253
THR A  31
 None
 1.25A 1ya3B-4mniA:
undetectable		 1ya3B-4mniA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 8 PHE A 212
GLU A 274
TYR A 152
TYR A 204
 None
 1.42A 2aoxA-4mniA:
undetectable		 2aoxA-4mniA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.06A 2dyrA-4mniA:
undetectable
2dyrJ-4mniA:
undetectable		 2dyrA-4mniA:
20.38
2dyrJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.06A 2dysA-4mniA:
undetectable
2dysJ-4mniA:
undetectable		 2dysA-4mniA:
20.38
2dysJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.04A 2dysN-4mniA:
undetectable
2dysW-4mniA:
undetectable		 2dysN-4mniA:
20.38
2dysW-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.07A 2eijA-4mniA:
undetectable
2eijJ-4mniA:
undetectable		 2eijA-4mniA:
20.38
2eijJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.05A 2eilA-4mniA:
undetectable
2eilJ-4mniA:
undetectable		 2eilA-4mniA:
20.38
2eilJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ASN A  56
LEU A 260
MET A  90
LEU A 253
THR A  31
 None
 1.22A 2oaxA-4mniA:
undetectable		 2oaxA-4mniA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ASN A  56
LEU A 260
MET A  90
LEU A 253
THR A  31
 None
 1.14A 2oaxC-4mniA:
undetectable		 2oaxC-4mniA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 8 SER A 170
PHE A  77
TYR A 173
ASN A  93
 173  A 401 (-2.6A)
None
173  A 401 (-4.4A)
None
 1.06A 2wekA-4mniA:
undetectable		 2wekA-4mniA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 8 SER A 170
PHE A  77
TYR A 173
ASN A  93
 173  A 401 (-2.6A)
None
173  A 401 (-4.4A)
None
 1.04A 2wekB-4mniA:
undetectable		 2wekB-4mniA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.10A 2zxwA-4mniA:
undetectable
2zxwJ-4mniA:
undetectable		 2zxwA-4mniA:
20.38
2zxwJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.05A 3abmA-4mniA:
undetectable
3abmJ-4mniA:
undetectable		 3abmA-4mniA:
20.38
3abmJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.06A 3asnA-4mniA:
undetectable
3asnJ-4mniA:
undetectable		 3asnA-4mniA:
20.38
3asnJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.07A 3asoA-4mniA:
undetectable
3asoJ-4mniA:
undetectable		 3asoA-4mniA:
20.38
3asoJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 304
GLY A 307
ARG A 174
ALA A 300
ASP A 106
 None
 1.17A 3ckkA-4mniA:
undetectable		 3ckkA-4mniA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 5 ASN A  93
THR A 186
SER A 170
ARG A 174
 None
None
173  A 401 (-2.6A)
None
 1.46A 3hlwB-4mniA:
undetectable		 3hlwB-4mniA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 7 ILE A  43
LEU A 214
THR A  76
THR A 220
 None
 1.19A 3nxuA-4mniA:
undetectable		 3nxuA-4mniA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 5 SER A 170
ARG A 168
TYR A 204
VAL A 184
 173  A 401 (-2.6A)
173  A 401 (-2.8A)
None
None
 1.28A 3sufC-4mniA:
undetectable		 3sufC-4mniA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ASN A  56
LEU A 260
MET A  90
LEU A 253
THR A  31
 None
 1.25A 3vhuA-4mniA:
undetectable		 3vhuA-4mniA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 LEU A 235
LEU A  34
LEU A 260
VAL A  45
LEU A  49
 None
 1.11A 4p65C-4mniA:
undetectable
4p65D-4mniA:
undetectable
4p65J-4mniA:
undetectable
4p65L-4mniA:
undetectable		 4p65C-4mniA:
6.49
4p65D-4mniA:
5.69
4p65J-4mniA:
5.69
4p65L-4mniA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 308
PHE A 323
THR A 321
LEU A 108
ARG A 142
 None
 1.49A 4z7fC-4mniA:
undetectable		 4z7fC-4mniA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 8 ILE A  65
VAL A  55
GLN A 249
GLU A  29
 None
 1.18A 5dqyA-4mniA:
1.3		 5dqyA-4mniA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		3 / 3 THR A 246
ASP A 247
ALA A 248
 None
 0.01A 5g5gB-4mniA:
undetectable		 5g5gB-4mniA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 182
GLY A 271
THR A 275
PHE A 228
THR A 153
 None
 1.35A 5jlcA-4mniA:
undetectable		 5jlcA-4mniA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 6 LEU A  63
MET A 237
THR A 236
LEU A 140
 None
 1.04A 5x1fA-4mniA:
undetectable
5x1fJ-4mniA:
undetectable		 5x1fA-4mniA:
20.38
5x1fJ-4mniA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 ALA A  37
TYR A 139
TYR A  98
GLU A 232
ALA A  91
 None
 1.49A 6dk1A-4mniA:
undetectable		 6dk1A-4mniA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 5 PHE A 319
VAL A 172
PRO A 103
VAL A 315
 None
173  A 401 (-4.6A)
None
None
 1.31A 6ekzA-4mniA:
undetectable		 6ekzA-4mniA:
13.46