SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 THR A  11
GLU A  18
ASP A  51
ILE A 211
TYR A 158
 SLB  A 401 (-4.0A)
None
SLB  A 401 (-3.3A)
None
None
 1.38A 1oltA-4mnpA:
undetectable		 1oltA-4mnpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 PHE A  92
VAL A 119
PHE A 108
ALA A 243
ALA A 121
 None
 1.29A 1q23A-4mnpA:
undetectable
1q23B-4mnpA:
undetectable		 1q23A-4mnpA:
18.40
1q23B-4mnpA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		3 / 3 MET A  54
ASN A  44
GLN A  16
 None
 1.04A 1xoqB-4mnpA:
undetectable		 1xoqB-4mnpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 5 LEU A 227
PRO A 228
LEU A 231
ILE A  37
 None
 0.81A 2qd4A-4mnpA:
undetectable		 2qd4A-4mnpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 PRO A 271
LEU A 190
THR A 269
ILE A 268
 None
 0.87A 3p50A-4mnpA:
undetectable		 3p50A-4mnpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 PRO A 271
LEU A 190
THR A 269
ILE A 268
 None
 0.86A 3p50B-4mnpA:
undetectable		 3p50B-4mnpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 PRO A 271
LEU A 190
THR A 269
ILE A 268
 None
 0.87A 3p50C-4mnpA:
undetectable		 3p50C-4mnpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 PRO A 271
LEU A 190
THR A 269
ILE A 268
 None
 0.86A 3p50D-4mnpA:
undetectable		 3p50D-4mnpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 PRO A 271
LEU A 190
THR A 269
ILE A 268
 None
 0.83A 3p50E-4mnpA:
undetectable		 3p50E-4mnpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 4 LEU A 227
PRO A 228
LEU A 231
ILE A  37
 None
 0.90A 4f4dB-4mnpA:
undetectable		 4f4dB-4mnpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 4 VAL A  99
ILE A  89
ASN A  93
VAL A 305
 None
 1.31A 5ajqA-4mnpA:
undetectable		 5ajqA-4mnpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		4 / 6 LEU A 139
PRO A 282
PHE A 283
GLU A 286
 None
 1.06A 5b8iA-4mnpA:
undetectable		 5b8iA-4mnpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 GLY A  71
PHE A  73
MET A   8
LEU A 120
ASP A 214
 None
 1.50A 5nknA-4mnpA:
undetectable		 5nknA-4mnpA:
16.92