SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 THR A 191
GLY A 257
GLY A 246
GLY A 250
 None
 0.66A 1d0vA-4mnrA:
undetectable		 1d0vA-4mnrA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
LYS A 185
SER A 237
ASN A 239
LYS A 397
GLY A 399
 None
 0.59A 1ghmA-4mnrA:
15.9		 1ghmA-4mnrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		7 / 12 SER A 182
LYS A 185
SER A 237
ASN A 239
THR A 383
LYS A 397
GLY A 399
 None
 0.54A 1i2wA-4mnrA:
16.5		 1i2wA-4mnrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
LYS A 185
SER A 237
ASN A 239
THR A 383
GLY A 399
 None
 0.59A 1i2wB-4mnrA:
16.7		 1i2wB-4mnrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 5 GLU A 429
TYR A 178
PRO A 180
ASP A 408
 None
 1.45A 1i7zB-4mnrA:
undetectable		 1i7zB-4mnrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 4 GLU A 429
TYR A 178
PRO A 180
ASP A 408
 None
 1.44A 1i7zD-4mnrA:
0.4		 1i7zD-4mnrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 THR A 191
GLY A 257
GLY A 246
GLY A 250
 None
 0.69A 1jhaA-4mnrA:
undetectable		 1jhaA-4mnrA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 6 ALA A 231
LEU A 245
GLU A 200
LEU A 193
 None
 0.95A 1mt1D-4mnrA:
undetectable
1mt1E-4mnrA:
undetectable		 1mt1D-4mnrA:
14.10
1mt1E-4mnrA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 4 ALA A 128
VAL A 318
ALA A 173
HIS A  58
 None
 1.26A 1q23F-4mnrA:
undetectable		 1q23F-4mnrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 ALA A 251
GLN A 285
LEU A 284
ALA A 281
VAL A 217
 None
 1.10A 1xdkA-4mnrA:
undetectable		 1xdkA-4mnrA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 PHE A 220
ASN A 219
GLY A 208
THR A 216
 None
 1.02A 1ykiA-4mnrA:
undetectable
1ykiB-4mnrA:
undetectable		 1ykiA-4mnrA:
20.00
1ykiB-4mnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 THR A 216
PHE A 220
ASN A 219
GLY A 208
 None
 1.05A 1ykiA-4mnrA:
undetectable
1ykiB-4mnrA:
undetectable		 1ykiA-4mnrA:
20.00
1ykiB-4mnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 PHE A 220
ASN A 219
GLY A 208
THR A 216
 None
 1.03A 1ykiC-4mnrA:
undetectable
1ykiD-4mnrA:
undetectable		 1ykiC-4mnrA:
20.00
1ykiD-4mnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 THR A 216
PHE A 220
ASN A 219
GLY A 208
 None
 1.03A 1ykiC-4mnrA:
undetectable
1ykiD-4mnrA:
undetectable		 1ykiC-4mnrA:
20.00
1ykiD-4mnrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 LYS A 185
SER A 237
ASN A 239
THR A 383
LYS A 397
GLY A 399
 None
 0.57A 1ymxA-4mnrA:
17.4		 1ymxA-4mnrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
SER A 237
ASN A 239
THR A 383
LYS A 397
GLY A 399
 None
 0.55A 1ymxA-4mnrA:
17.4		 1ymxA-4mnrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
LYS A 185
SER A 237
ASN A 239
LYS A 397
GLY A 399
 None
 0.59A 1ymxB-4mnrA:
17.5		 1ymxB-4mnrA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 ALA A 118
ALA A 117
GLN A 119
ALA A 143
LEU A 448
 None
 0.98A 2aclA-4mnrA:
undetectable
2aclE-4mnrA:
undetectable		 2aclA-4mnrA:
20.04
2aclE-4mnrA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 GLU A 349
GLY A 348
ASN A 347
ALA A 346
ALA A 102
 None
 1.17A 2bm9C-4mnrA:
undetectable		 2bm9C-4mnrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 LEU A 271
PHE A 269
LEU A 110
ALA A 141
ILE A 139
 None
 1.13A 2bxpA-4mnrA:
undetectable		 2bxpA-4mnrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 LEU A 254
ALA A 251
SER A 280
ALA A 258
PHE A 184
 None
 1.20A 2ejtA-4mnrA:
undetectable		 2ejtA-4mnrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 PHE A 269
PRO A 270
ALA A 128
ALA A 143
LEU A 110
 None
 1.04A 2x2nB-4mnrA:
undetectable		 2x2nB-4mnrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 PHE A 269
PRO A 270
ALA A 128
ALA A 143
LEU A 110
 None
 0.99A 2x2nC-4mnrA:
undetectable		 2x2nC-4mnrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 PRO A 288
ALA A 292
ALA A 295
ILE A 212
 None
 0.81A 3dtuC-4mnrA:
undetectable
3dtuD-4mnrA:
undetectable		 3dtuC-4mnrA:
22.34
3dtuD-4mnrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 LYS A 185
SER A 237
ASN A 239
THR A 383
LYS A 397
GLY A 399
 None
 0.43A 3hlwA-4mnrA:
17.5		 3hlwA-4mnrA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
ASN A 239
THR A 383
LYS A 397
THR A 398
GLY A 399
 None
 0.29A 3hlwB-4mnrA:
17.4		 3hlwB-4mnrA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 LYS A 185
ASN A 239
LYS A 397
THR A 398
GLY A 399
 None
 0.41A 3huoA-4mnrA:
17.4		 3huoA-4mnrA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 GLY A 175
MET A 142
VAL A  59
LEU A 339
ILE A 267
 None
 1.21A 3mnoA-4mnrA:
undetectable		 3mnoA-4mnrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 GLY A 175
MET A 142
VAL A  59
LEU A 339
ILE A 267
 None
 1.23A 3mnpA-4mnrA:
undetectable		 3mnpA-4mnrA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 GLY A 396
VAL A 424
ALA A 415
ALA A 417
SER A 182
 None
 1.19A 3mteA-4mnrA:
undetectable		 3mteA-4mnrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.62A 3ny4A-4mnrA:
16.9		 3ny4A-4mnrA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 6 GLY A 199
THR A 202
GLU A 200
ASP A 196
 None
 1.04A 3ps9A-4mnrA:
undetectable		 3ps9A-4mnrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 LYS A 185
SER A 237
ASN A 239
LYS A 397
GLY A 399
 None
 0.32A 3q07A-4mnrA:
17.3		 3q07A-4mnrA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 LYS A 185
SER A 237
ASN A 239
LYS A 397
GLY A 399
 None
 0.56A 3q07B-4mnrA:
11.3		 3q07B-4mnrA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
SER A 237
ASN A 239
LYS A 397
THR A 398
GLY A 399
 None
 0.57A 3sh8A-4mnrA:
17.1		 3sh8A-4mnrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 PHE A 184
GLY A 181
GLY A 246
MET A 278
 None
 0.95A 3v3nB-4mnrA:
undetectable		 3v3nB-4mnrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 8 PHE A 184
GLY A 181
GLY A 246
MET A 278
 None
 0.95A 3v3nC-4mnrA:
undetectable		 3v3nC-4mnrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 9 THR A 234
LEU A 230
GLY A 199
VAL A 371
VAL A 374
 None
 1.33A 4c9kB-4mnrA:
undetectable		 4c9kB-4mnrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 9 THR A 234
LEU A 230
GLY A 199
VAL A 371
VAL A 374
 None
 1.36A 4c9pA-4mnrA:
undetectable		 4c9pA-4mnrA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 10 THR A 234
LEU A 230
GLY A 199
VAL A 371
VAL A 374
 None
 1.35A 4c9pB-4mnrA:
undetectable		 4c9pB-4mnrA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		7 / 12 LYS A 185
SER A 237
ASN A 239
THR A 383
LYS A 397
THR A 398
GLY A 399
 None
 0.61A 4euzA-4mnrA:
16.8		 4euzA-4mnrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		7 / 12 LYS A 185
SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.75A 4euzA-4mnrA:
16.8		 4euzA-4mnrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 10 SER A 237
ASN A 239
LYS A 397
THR A 398
GLY A 399
 None
 0.55A 4fh2A-4mnrA:
17.9		 4fh2A-4mnrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 6 PRO A 420
GLY A 369
ALA A 395
GLN A 361
 None
 1.11A 4g0uA-4mnrA:
undetectable		 4g0uA-4mnrA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		3 / 3 VAL A 363
SER A 364
THR A 367
 None
 0.47A 4luhA-4mnrA:
undetectable		 4luhA-4mnrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
SER A 237
ASN A 239
LYS A 397
THR A 398
GLY A 399
 None
 0.54A 4n9kA-4mnrA:
17.1		 4n9kA-4mnrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
SER A 237
ASN A 239
LYS A 397
THR A 398
GLY A 399
 None
 0.52A 4n9kB-4mnrA:
16.5		 4n9kB-4mnrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
ASN A 239
THR A 383
LYS A 397
THR A 398
GLY A 399
 None
 0.62A 4pm5A-4mnrA:
17.6		 4pm5A-4mnrA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 LYS A 185
SER A 237
ASN A 239
THR A 383
LYS A 397
GLY A 399
 None
 0.71A 4pm7A-4mnrA:
17.7		 4pm7A-4mnrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
ASN A 239
THR A 383
LYS A 397
THR A 398
GLY A 399
 None
 0.61A 4pm9A-4mnrA:
17.6		 4pm9A-4mnrA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 7 LEU A 277
THR A 317
LEU A 177
THR A 273
 None
 0.87A 4z90A-4mnrA:
undetectable
4z90B-4mnrA:
undetectable
4z90C-4mnrA:
undetectable
4z90D-4mnrA:
undetectable
4z90E-4mnrA:
undetectable		 4z90A-4mnrA:
20.39
4z90B-4mnrA:
20.39
4z90C-4mnrA:
20.39
4z90D-4mnrA:
20.39
4z90E-4mnrA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 7 ALA A 223
GLY A 208
SER A 206
GLY A 226
 None
 0.84A 5e26A-4mnrA:
undetectable
5e26B-4mnrA:
undetectable		 5e26A-4mnrA:
22.49
5e26B-4mnrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		4 / 7 GLY A 208
SER A 206
GLY A 226
ALA A 223
 None
 0.88A 5e26C-4mnrA:
undetectable
5e26D-4mnrA:
undetectable		 5e26C-4mnrA:
22.49
5e26D-4mnrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 11 SER A 182
SER A 237
ASN A 239
LYS A 397
THR A 398
GLY A 399
 None
 0.54A 5ghzA-4mnrA:
16.5		 5ghzA-4mnrA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 10 SER A 182
SER A 237
ASN A 239
LYS A 397
THR A 398
GLY A 399
 None
 0.56A 5ghzB-4mnrA:
17.0		 5ghzB-4mnrA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 VAL A 300
GLU A 298
ASP A 283
ALA A 294
PRO A 180
 None
 1.25A 5hnzB-4mnrA:
undetectable		 5hnzB-4mnrA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 11 VAL A 106
ASP A 341
THR A 109
TYR A  76
LEU A  80
 None
 1.41A 5jh7D-4mnrA:
undetectable		 5jh7D-4mnrA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 PHE A 352
PHE A 269
ALA A 128
ALA A 143
LEU A 110
 None
 1.15A 5tl8A-4mnrA:
undetectable		 5tl8A-4mnrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 11 GLU A 298
GLY A 246
ALA A 295
ALA A 292
ILE A 212
 None
 0.99A 5yk2A-4mnrA:
undetectable		 5yk2A-4mnrA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.66A 6b5yB-4mnrA:
7.9		 6b5yB-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.73A 6b5yD-4mnrA:
16.9		 6b5yD-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.58A 6b68B-4mnrA:
16.9		 6b68B-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 SER A 237
THR A 383
LYS A 397
GLY A 399
THR A 400
 None
 0.61A 6b68D-4mnrA:
16.7		 6b68D-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
 None
 0.57A 6b69A-4mnrA:
16.9
6b69B-4mnrA:
16.6		 6b69A-4mnrA:
13.93
6b69B-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.57A 6b69A-4mnrA:
16.9
6b69B-4mnrA:
16.6		 6b69A-4mnrA:
13.93
6b69B-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		7 / 12 SER A 182
SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.77A 6b69D-4mnrA:
7.9		 6b69D-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 182
SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
 None
 0.59A 6b6aB-4mnrA:
17.1		 6b6aB-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		6 / 12 SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.60A 6b6aB-4mnrA:
17.1		 6b6aB-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		7 / 12 SER A 182
SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.91A 6b6dA-4mnrA:
16.8		 6b6dA-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		7 / 12 SER A 182
SER A 237
THR A 383
LYS A 397
THR A 398
GLY A 399
THR A 400
 None
 0.79A 6b6eA-4mnrA:
16.7		 6b6eA-4mnrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 SER A 237
ASN A 239
THR A 383
LYS A 397
GLY A 399
 None
 0.29A 6c79A-4mnrA:
17.6		 6c79A-4mnrA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Eggerthella
lenta) 		5 / 12 SER A 237
THR A 383
LYS A 397
GLY A 399
ASN A 407
 None
 1.05A 6c79A-4mnrA:
17.6		 6c79A-4mnrA:
10.77