SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 6 ASN A 252
PHE A 285
ALA A 317
GLY A 316
 ADP  A 402 (-2.9A)
ADP  A 402 (-4.8A)
None
None
 1.14A 1l5qB-4mobA:
undetectable		 1l5qB-4mobA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		3 / 3 ARG A 313
ARG A 179
ARG A 312
 ADP  A 402 (-3.4A)
None
ADP  A 402 (-3.7A)
 1.03A 1l7fA-4mobA:
undetectable		 1l7fA-4mobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		3 / 3 ARG A 313
ARG A 179
ARG A 312
 ADP  A 402 (-3.4A)
None
ADP  A 402 (-3.7A)
 1.06A 1l7hA-4mobA:
undetectable		 1l7hA-4mobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 6 ASN A 252
PHE A 285
ALA A 317
GLY A 316
 ADP  A 402 (-2.9A)
ADP  A 402 (-4.8A)
None
None
 1.14A 1l7xA-4mobA:
undetectable		 1l7xA-4mobA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 6 ASN A 252
PHE A 285
ALA A 317
GLY A 316
 ADP  A 402 (-2.9A)
ADP  A 402 (-4.8A)
None
None
 1.13A 1l7xB-4mobA:
undetectable		 1l7xB-4mobA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 6 ASN A 252
PHE A 285
ALA A 317
GLY A 316
 ADP  A 402 (-2.9A)
ADP  A 402 (-4.8A)
None
None
 1.13A 3ddsB-4mobA:
undetectable		 3ddsB-4mobA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		3 / 3 ASP A 310
SER A 307
ARG A 179
 None
 0.75A 3loqA-4mobA:
undetectable		 3loqA-4mobA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 8 GLU A  86
ARG A 147
ARG A 143
ASP A  57
 None
 0.98A 3mjrD-4mobA:
undetectable		 3mjrD-4mobA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 5 ILE A  71
VAL A  91
PHE A 108
HIS A  19
 None
 1.25A 4rzvA-4mobA:
undetectable		 4rzvA-4mobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 8 ALA A 207
THR A 211
THR A 214
ALA A  22
 None
 0.84A 5x2tI-4mobA:
undetectable
5x2tJ-4mobA:
undetectable
5x2tK-4mobA:
undetectable
5x2tL-4mobA:
undetectable		 5x2tI-4mobA:
19.09
5x2tJ-4mobA:
20.24
5x2tK-4mobA:
19.09
5x2tL-4mobA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens) 		4 / 7 THR A 130
ASP A 133
LEU A 129
THR A 127
 None
 0.96A 5zsfA-4mobA:
undetectable
5zsfB-4mobA:
undetectable		 5zsfA-4mobA:
13.41
5zsfB-4mobA:
13.41