SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		4 / 7 TYR A 151
GLY A 120
ILE A 140
GLY A 175
 None
 0.84A 11gsB-4mouA:
undetectable		 11gsB-4mouA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		4 / 8 LEU A 186
ALA A 183
PHE A 178
TYR A 151
 None
 0.81A 1epbB-4mouA:
undetectable		 1epbB-4mouA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 155
VAL A 160
SER A  97
SER A 127
LEU A  63
 None
 1.40A 1kiaD-4mouA:
undetectable		 1kiaD-4mouA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 150
GLY A 155
ALA A 128
SER A 127
SER A  97
 None
 1.21A 1nbhA-4mouA:
undetectable		 1nbhA-4mouA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 150
GLY A 155
ALA A 128
SER A 127
SER A  97
 None
 1.20A 1nbhC-4mouA:
undetectable		 1nbhC-4mouA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 150
GLY A 155
ALA A 128
SER A 127
SER A  97
 None
 1.20A 1nbhD-4mouA:
undetectable		 1nbhD-4mouA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 11 ILE A 132
PHE A 131
ALA A 190
GLU A 199
LEU A 205
 None
 1.31A 2v0mD-4mouA:
undetectable		 2v0mD-4mouA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		4 / 6 LEU A  63
VAL A  26
LEU A 106
ASP A  55
 None
 0.86A 3cs9D-4mouA:
undetectable		 3cs9D-4mouA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 11 VAL A  23
ALA A  59
SER A 208
LEU A 205
VAL A  62
 None
 1.44A 4kyaA-4mouA:
undetectable		 4kyaA-4mouA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 10 VAL A  23
ALA A  59
SER A 208
LEU A 205
VAL A  62
 None
 1.43A 4kyaC-4mouA:
undetectable		 4kyaC-4mouA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 145
GLY A 175
ALA A  72
MET A 119
GLY A 120
 None
 1.05A 4r29A-4mouA:
undetectable		 4r29A-4mouA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 145
GLY A 175
ALA A  72
MET A 119
GLY A 120
 None
 1.02A 4r29B-4mouA:
undetectable		 4r29B-4mouA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 145
GLY A 175
ALA A  72
MET A 119
GLY A 120
 None
 1.07A 4r29C-4mouA:
undetectable		 4r29C-4mouA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 145
GLY A 175
ALA A  72
MET A 119
GLY A 120
 None
 1.01A 4r29D-4mouA:
undetectable		 4r29D-4mouA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		4 / 7 VAL A  17
ILE A  19
VAL A  61
ALA A  24
 None
 0.64A 5osrA-4mouA:
undetectable		 5osrA-4mouA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 GLN A  51
LEU A  48
ILE A  19
ARG A 210
HIS A 218
 None
 1.18A 5uhbC-4mouA:
0.1		 5uhbC-4mouA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 GLN A  51
LEU A  48
ILE A  19
ARG A 210
HIS A 218
 None
 1.20A 5uhcC-4mouA:
undetectable		 5uhcC-4mouA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 114
LEU A  96
ALA A 126
GLY A 141
LEU A 142
 None
 0.99A 6b0cD-4mouA:
undetectable		 6b0cD-4mouA:
12.85