SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 SER A 140
ILE A 139
VAL A 243
THR A 210
 None
 1.16A 1u70A-4mowA:
undetectable		 1u70A-4mowA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 GLY A 131
GLY A 133
ILE A  10
LEU A  88
ALA A 126
 None
 1.08A 1x7pA-4mowA:
3.1
1x7pB-4mowA:
3.1		 1x7pA-4mowA:
22.90
1x7pB-4mowA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 THR A 147
PRO A 148
GLY A 159
ASP A 162
 None
 1.00A 2ddwB-4mowA:
5.7		 2ddwB-4mowA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 ALA A  14
ALA A  27
ALA A  31
VAL A  87
 None
 0.89A 2nyrB-4mowA:
4.8		 2nyrB-4mowA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 221
GLY A  13
 None
 0.81A 2qe6A-4mowA:
6.1		 2qe6A-4mowA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 221
GLY A  13
 None
 0.86A 2qe6B-4mowA:
6.0		 2qe6B-4mowA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 THR A 122
LEU A  85
ALA A  78
VAL A  61
GLY A  62
 None
 1.08A 2ve3A-4mowA:
undetectable		 2ve3A-4mowA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  83
ASP A  86
ILE A  51
ALA A  31
ALA A  27
 None
 1.05A 3sueA-4mowA:
undetectable		 3sueA-4mowA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 SER A 230
LEU A   4
ILE A 182
ILE A 137
VAL A  87
 None
 1.16A 3w67A-4mowA:
2.4		 3w67A-4mowA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 SER A 230
LEU A   4
ILE A 182
ILE A 137
VAL A  87
 None
 1.12A 3w67B-4mowA:
1.9		 3w67B-4mowA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 SER A 230
LEU A   4
ILE A 182
ILE A 137
VAL A  87
 None
 1.10A 3w67D-4mowA:
2.3		 3w67D-4mowA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  63
GLY A  62
THR A  77
THR A  12
GLY A  13
 None
 0.75A 4e3aB-4mowA:
7.1		 4e3aB-4mowA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ASN A 219
VAL A  33
VAL A  11
GLY A  19
ILE A  22
 None
 1.03A 5vopA-4mowA:
undetectable		 5vopA-4mowA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 ARG A 214
GLY A 216
THR A 192
VAL A 188
 None
 1.04A 5ysiA-4mowA:
undetectable		 5ysiA-4mowA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  23
GLY A  17
SER A  49
ALA A  27
TYR A  82
 None
 1.18A 5zvgA-4mowA:
6.4		 5zvgA-4mowA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 166
THR A 165
ARG A 178
SER A 135
 None
 0.85A 6jnhA-4mowA:
3.5		 6jnhA-4mowA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4mow GLUCOSE
1-DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 166
THR A 165
ARG A 178
SER A 135
 None
 0.87A 6jogA-4mowA:
3.6		 6jogA-4mowA:
21.40