SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 7 ARG A 127
ASP A 167
THR A 165
GLN A 132
 None
ZN  A 400 ( 1.8A)
None
None
 1.16A 2jc9A-4mphA:
undetectable		 2jc9A-4mphA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 6 ARG A 127
ASP A 167
ILE A 220
LEU A 190
TYR A 215
 None
ZN  A 400 ( 1.8A)
None
None
None
 1.41A 2ya7A-4mphA:
undetectable		 2ya7A-4mphA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 6 ARG A 127
ASP A 167
ILE A 220
LEU A 190
TYR A 215
 None
ZN  A 400 ( 1.8A)
None
None
None
 1.41A 2ya7B-4mphA:
undetectable		 2ya7B-4mphA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 6 ARG A 127
ASP A 167
ILE A 220
TYR A 215
 None
ZN  A 400 ( 1.8A)
None
None
 1.43A 2ya7C-4mphA:
undetectable		 2ya7C-4mphA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 6 ARG A 127
ASP A 167
ILE A 220
LEU A 190
TYR A 215
 None
ZN  A 400 ( 1.8A)
None
None
None
 1.41A 2ya7D-4mphA:
undetectable		 2ya7D-4mphA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 12 LEU A 106
GLY A 198
ALA A 197
ILE A 201
LEU A 109
 None
 1.06A 3ogqB-4mphA:
undetectable		 3ogqB-4mphA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 10 ALA A 153
VAL A  65
GLU A 159
LEU A  71
THR A 165
 None
 1.33A 4zmeB-4mphA:
undetectable		 4zmeB-4mphA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 9 LEU A 164
GLY A 163
LEU A  98
LEU A 106
ALA A 102
 None
 1.01A 5dqfA-4mphA:
undetectable		 5dqfA-4mphA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 THR A 162
PRO A  77
ASP A  79
 None
 0.76A 5l8dB-4mphA:
undetectable		 5l8dB-4mphA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 THR A 162
PRO A  77
ASP A  79
 None
 0.76A 5mwuB-4mphA:
undetectable		 5mwuB-4mphA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 5 ARG A 127
MET A 166
THR A 165
LEU A  98
 None
 1.32A 5x1bW-4mphA:
undetectable		 5x1bW-4mphA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4mph D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 5 ARG A 127
MET A 166
THR A 165
LEU A  98
 None
 1.40A 6nknJ-4mphA:
undetectable		 6nknJ-4mphA:
15.25