SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 10 LEU A 395
VAL A 335
ILE A 325
LEU A 301
LEU A 141
 None
 1.21A 1cqpA-4mpsA:
undetectable
1cqpB-4mpsA:
undetectable		 1cqpA-4mpsA:
18.27
1cqpB-4mpsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.66A 1p7lD-4mpsA:
undetectable		 1p7lD-4mpsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.65A 1p7lC-4mpsA:
undetectable		 1p7lC-4mpsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.63A 1rg9B-4mpsA:
undetectable		 1rg9B-4mpsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.64A 1rg9A-4mpsA:
undetectable		 1rg9A-4mpsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.64A 1rg9D-4mpsA:
undetectable		 1rg9D-4mpsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.64A 1rg9C-4mpsA:
undetectable		 1rg9C-4mpsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 12 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
 None
 1.20A 2j7xA-4mpsA:
undetectable		 2j7xA-4mpsA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 6 ARG A 180
ASP A 336
ILE A 337
GLU A 381
 None
 1.23A 2ya7C-4mpsA:
undetectable		 2ya7C-4mpsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 12 LEU A 395
MET A 375
ILE A 325
MET A 329
PHE A 398
 None
 0.93A 2ygnA-4mpsA:
undetectable		 2ygnA-4mpsA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 7 HIS A 367
GLY A 321
GLU A 372
PHE A 340
 None
 0.97A 3tehB-4mpsA:
undetectable		 3tehB-4mpsA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 12 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
 None
 1.18A 4j24B-4mpsA:
undetectable		 4j24B-4mpsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 12 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
 None
 1.19A 4j24C-4mpsA:
undetectable		 4j24C-4mpsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 12 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
 None
 1.22A 4j26A-4mpsA:
undetectable		 4j26A-4mpsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 12 MET A 328
LEU A 323
MET A 149
LEU A 293
ILE A 250
 None
 1.22A 4j26B-4mpsA:
undetectable		 4j26B-4mpsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		3 / 3 LEU A 206
MET A 328
ASP A 255
 None
 0.78A 4j7xB-4mpsA:
undetectable		 4j7xB-4mpsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.73A 4kttD-4mpsA:
undetectable		 4kttD-4mpsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		5 / 11 TYR A 291
VAL A 175
ILE A 226
MET A 328
LEU A 206
 None
 1.37A 4lhmA-4mpsA:
undetectable		 4lhmA-4mpsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.69A 4ndnB-4mpsA:
undetectable		 4ndnB-4mpsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.72A 4ndnD-4mpsA:
undetectable		 4ndnD-4mpsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		3 / 3 TYR A 278
SER A 280
TRP A 162
 None
 0.83A 5n8jB-4mpsA:
undetectable		 5n8jB-4mpsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		3 / 3 TYR A 278
SER A 280
TRP A 162
 None
 0.78A 5n8jA-4mpsA:
undetectable		 5n8jA-4mpsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		3 / 3 TYR A 278
SER A 280
TRP A 162
 None
 0.82A 5n8jD-4mpsA:
undetectable		 5n8jD-4mpsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.71A 5t8sA-4mpsA:
undetectable		 5t8sA-4mpsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4mps BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Rattus
norvegicus) 		4 / 7 ALA A 187
GLU A 339
ASP A 336
ILE A 325
 None
 0.68A 6fbnA-4mpsA:
undetectable		 6fbnA-4mpsA:
21.65