SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 LEU B  71
LEU B  68
VAL B  67
VAL B 137
HIS B  92
 HEM  B 201 ( 4.6A)
None
HEM  B 201 ( 3.8A)
None
HEM  B 201 (-3.3A)
 1.23A 1db1A-4mqjB:
undetectable		 1db1A-4mqjB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 LEU B  71
LEU B  68
VAL B  67
VAL B 137
HIS B  92
 HEM  B 201 ( 4.6A)
None
HEM  B 201 ( 3.8A)
None
HEM  B 201 (-3.3A)
 1.24A 1ie9A-4mqjB:
undetectable		 1ie9A-4mqjB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.0A)
None
HEM  B 201 ( 3.8A)
HEM  B 201 (-3.3A)
 0.82A 1lh6A-4mqjB:
13.4		 1lh6A-4mqjB:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 9 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 201 (-4.6A)
 1.27A 1tbfA-4mqjB:
undetectable		 1tbfA-4mqjB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		4 / 8 LEU B  78
MET B 133
TRP B 130
THR B  10
 None
 1.31A 1uw6P-4mqjB:
undetectable
1uw6T-4mqjB:
undetectable		 1uw6P-4mqjB:
20.63
1uw6T-4mqjB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 LEU B  81
GLY B  72
LEU B 114
ILE B  11
MET B 133
 None
 1.25A 5y2tA-4mqjB:
undetectable		 5y2tA-4mqjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		4 / 5 GLN B 127
VAL B 126
TRP B 130
THR B  12
 None
 1.45A 6cduI-4mqjB:
2.6
6cduJ-4mqjB:
2.8		 6cduI-4mqjB:
18.27
6cduJ-4mqjB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.3A)
HEM  B 201 (-3.5A)
None
 1.11A 6ew0B-4mqjB:
undetectable		 6ew0B-4mqjB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.3A)
HEM  B 201 (-3.5A)
None
 1.11A 6ew0D-4mqjB:
undetectable		 6ew0D-4mqjB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.3A)
HEM  B 201 (-3.5A)
None
 1.11A 6ew0H-4mqjB:
undetectable		 6ew0H-4mqjB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 LEU B  32
LEU B  48
HIS B  63
SER B  70
LEU B  31
 None
None
HEM  B 201 (-4.3A)
HEM  B 201 (-3.5A)
None
 1.11A 6ew0I-4mqjB:
undetectable		 6ew0I-4mqjB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens) 		4 / 7 HIS B  97
ARG B 144
HIS B 146
ASP B  94
 None
 1.30A 6mn4F-4mqjB:
undetectable		 6mn4F-4mqjB:
23.05