SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.85A 1dvxA-4mr0A:
undetectable		 1dvxA-4mr0A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.83A 1dvxB-4mr0A:
undetectable		 1dvxB-4mr0A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.73A 1ictB-4mr0A:
undetectable		 1ictB-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 5 GLY A 303
GLN A 302
VAL A 382
SER A 337
 None
 1.33A 1p6kB-4mr0A:
undetectable		 1p6kB-4mr0A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 PHE A 189
SER A 253
ALA A 179
ALA A 178
HIS A 207
 None
 1.31A 1q23A-4mr0A:
undetectable
1q23B-4mr0A:
undetectable		 1q23A-4mr0A:
14.81
1q23B-4mr0A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
THR A 232
ILE A 250
ILE A 284
 None
 1.02A 1rd7B-4mr0A:
undetectable		 1rd7B-4mr0A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
THR A 232
ILE A 250
ILE A 284
 None
 1.08A 1re7A-4mr0A:
undetectable		 1re7A-4mr0A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 5 GLY A 303
GLN A 302
VAL A 382
SER A 337
 None
 1.35A 1rs6B-4mr0A:
undetectable		 1rs6B-4mr0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 504
GLU A 532
ALA A 470
VAL A 468
 None
 1.04A 1sn5A-4mr0A:
undetectable		 1sn5A-4mr0A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.83A 1tyrA-4mr0A:
undetectable		 1tyrA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 5 GLY A 303
GLN A 302
VAL A 382
SER A 337
 None
 1.31A 1zzuB-4mr0A:
undetectable		 1zzuB-4mr0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 GLY A 414
ILE A 469
ILE A 484
VAL A 423
ILE A 425
 None
 0.88A 2hs1B-4mr0A:
undetectable		 2hs1B-4mr0A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.83A 2roxB-4mr0A:
undetectable		 2roxB-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 8 LEU A 202
VAL A 295
ILE A 216
PHE A 282
 None
 0.95A 2weyB-4mr0A:
undetectable		 2weyB-4mr0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.94A 3cfqA-4mr0A:
undetectable		 3cfqA-4mr0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 GLY A 219
ASP A 258
GLY A 280
ILE A 228
ILE A 216
 None
 1.03A 3oxcB-4mr0A:
undetectable		 3oxcB-4mr0A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_A_DCKA401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 9 SER A 337
TYR A 412
THR A 383
ASN A 450
TYR A 452
 None
 1.24A 3ppoA-4mr0A:
0.0		 3ppoA-4mr0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PPO_B_DCKB401_0
(GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 9 SER A 337
TYR A 412
THR A 383
ASN A 450
TYR A 452
 None
 1.27A 3ppoB-4mr0A:
0.0		 3ppoB-4mr0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 8 GLY A 280
SER A 279
SER A 378
THR A 256
 None
 0.77A 3pwwA-4mr0A:
undetectable		 3pwwA-4mr0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 8 GLY A 280
SER A 279
SER A 378
THR A 296
 None
 0.67A 3pwwA-4mr0A:
undetectable		 3pwwA-4mr0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		3 / 3 THR A 503
VAL A 529
GLU A 532
 None
 0.57A 3v4tA-4mr0A:
undetectable
3v4tD-4mr0A:
undetectable		 3v4tA-4mr0A:
21.17
3v4tD-4mr0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 VAL A 415
VAL A 497
ILE A 484
LEU A 521
VAL A 524
 None
 1.05A 3w68B-4mr0A:
undetectable		 3w68B-4mr0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 VAL A 497
ILE A 507
ILE A 519
LEU A 521
VAL A 524
 None
 0.87A 3w68C-4mr0A:
undetectable		 3w68C-4mr0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 VAL A 415
VAL A 497
ILE A 484
LEU A 521
VAL A 524
 None
 1.06A 3w68D-4mr0A:
undetectable		 3w68D-4mr0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 VAL A 497
ILE A 507
ILE A 519
LEU A 521
VAL A 524
 None
 0.88A 3w68D-4mr0A:
undetectable		 3w68D-4mr0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 GLY A 219
ASN A 218
LEU A 273
ASN A 272
 None
 0.97A 3zqtA-4mr0A:
undetectable		 3zqtA-4mr0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.71A 4d7bB-4mr0A:
undetectable		 4d7bB-4mr0A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 ALA A 354
TYR A 353
ILE A 284
GLY A 285
 None
 0.65A 4eatA-4mr0A:
undetectable		 4eatA-4mr0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.78A 4i89A-4mr0A:
undetectable		 4i89A-4mr0A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		3 / 3 LYS A 426
LEU A 424
ALA A 470
 None
CA  A 702 ( 4.5A)
None
 0.68A 4iizA-4mr0A:
undetectable		 4iizA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.71A 4ik7A-4mr0A:
undetectable		 4ik7A-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.82A 4ikiB-4mr0A:
undetectable		 4ikiB-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.75A 4iklA-4mr0A:
undetectable
4iklB-4mr0A:
undetectable		 4iklA-4mr0A:
12.41
4iklB-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
THR A 232
ILE A 250
ILE A 284
 None
 1.06A 4kjkA-4mr0A:
undetectable		 4kjkA-4mr0A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 PHE A 558
ILE A 542
PHE A 587
ASN A 588
 None
 1.23A 4o7gA-4mr0A:
undetectable
4o7gB-4mr0A:
undetectable		 4o7gA-4mr0A:
16.36
4o7gB-4mr0A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 PHE A 558
ILE A 542
PHE A 587
ASN A 588
 None
 1.27A 4o7gB-4mr0A:
undetectable		 4o7gB-4mr0A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
THR A 232
ILE A 250
ILE A 284
 None
 1.11A 4pthA-4mr0A:
undetectable		 4pthA-4mr0A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
THR A 232
ILE A 250
ILE A 284
 None
 1.11A 4ptjA-4mr0A:
undetectable		 4ptjA-4mr0A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
THR A 232
ILE A 250
ILE A 284
 None
 1.02A 4x5jA-4mr0A:
undetectable		 4x5jA-4mr0A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.79A 5bojA-4mr0A:
undetectable		 5bojA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.79A 5bojB-4mr0A:
undetectable		 5bojB-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 PHE A 201
SER A 153
VAL A 187
ASP A 173
 None
 1.24A 5hesA-4mr0A:
undetectable		 5hesA-4mr0A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.77A 5l4iA-4mr0A:
undetectable		 5l4iA-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 6 LYS A 426
LEU A 424
ALA A 470
THR A 503
 None
CA  A 702 ( 4.5A)
None
None
 0.78A 5l4iB-4mr0A:
undetectable		 5l4iB-4mr0A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 171
PHE A 189
ILE A 175
ILE A 284
ALA A 283
 None
 1.01A 5vceA-4mr0A:
undetectable		 5vceA-4mr0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ALA A 470
LEU A 403
ILE A 402
VAL A 449
PHE A 430
 None
 1.28A 5vlmB-4mr0A:
undetectable		 5vlmB-4mr0A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 5 GLY A 303
GLN A 302
VAL A 382
SER A 337
 None
 1.33A 5vunA-4mr0A:
undetectable		 5vunA-4mr0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
LYS A 293
THR A 232
ILE A 250
 None
 1.26A 5z6fA-4mr0A:
undetectable		 5z6fA-4mr0A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		4 / 7 THR A 366
LEU A 315
ILE A 292
THR A 291
 BME  A 701 (-4.4A)
BME  A 701 ( 4.3A)
None
None
 0.90A 5zsfA-4mr0A:
2.8
5zsfB-4mr0A:
3.5		 5zsfA-4mr0A:
7.15
5zsfB-4mr0A:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		5 / 12 ILE A 306
ALA A 281
THR A 232
ILE A 250
ILE A 284
 None
 1.09A 7dfrA-4mr0A:
undetectable		 7dfrA-4mr0A:
12.11