SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY A  68
PRO A  60
HIS A 170
SER A 152
MET A 312
 None
None
2BY  A 501 (-4.1A)
2BY  A 501 ( 4.9A)
None
 1.42A 1fdsA-4mrmA:
5.4		 1fdsA-4mrmA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 7 SER B 155
PHE B 172
VAL B 176
ALA B 164
 None
 0.99A 1fo4B-4mrmB:
undetectable		 1fo4B-4mrmB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 12 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.34A 1q23B-4mrmA:
undetectable		 1q23B-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 12 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.38A 1q23C-4mrmA:
undetectable		 1q23C-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.32A 1q23E-4mrmA:
undetectable		 1q23E-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 11 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.31A 1q23F-4mrmA:
undetectable		 1q23F-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 11 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.35A 1q23I-4mrmA:
undetectable		 1q23I-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.28A 1q23K-4mrmA:
undetectable		 1q23K-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 7 VAL A 181
ALA A 216
PHE A 274
THR A 194
 None
 1.07A 2q6oA-4mrmA:
3.3		 2q6oA-4mrmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 6 MET A 126
ILE A 357
PRO A  60
SER A 101
 None
 1.19A 2qd3B-4mrmA:
3.0		 2qd3B-4mrmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 6 MET A 126
ILE A 357
SER A 101
MET A  61
 None
 1.34A 2qd3B-4mrmA:
3.0		 2qd3B-4mrmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 6 LEU B 395
ILE B 398
MET B 373
VAL B  81
 None
 1.01A 2ygoA-4mrmB:
undetectable		 2ygoA-4mrmB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		5 / 12 ALA B 116
GLU A 138
SER B 145
LEU A 135
TYR A 117
 None
 1.26A 3eigA-4mrmB:
2.4		 3eigA-4mrmB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		5 / 12 ASN B 180
THR B 200
ILE B 280
ILE B 186
PRO B 282
 None
 1.12A 3kpbA-4mrmB:
undetectable		 3kpbA-4mrmB:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 7 PRO B 464
ILE B 250
LEU B 252
ILE B 315
 None
 0.97A 3p50A-4mrmB:
undetectable		 3p50A-4mrmB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 7 PRO B 464
ILE B 250
LEU B 252
ILE B 315
 None
 0.98A 3p50B-4mrmB:
undetectable		 3p50B-4mrmB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 7 PRO B 464
ILE B 250
LEU B 252
ILE B 315
 None
 0.96A 3p50C-4mrmB:
undetectable		 3p50C-4mrmB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 7 PRO B 464
ILE B 250
LEU B 252
ILE B 315
 None
 0.96A 3p50D-4mrmB:
undetectable		 3p50D-4mrmB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 7 PRO B 464
ILE B 250
LEU B 252
ILE B 315
 None
 0.96A 3p50E-4mrmB:
undetectable		 3p50E-4mrmB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.31A 3u9fI-4mrmA:
undetectable		 3u9fI-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 12 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.21A 3u9fJ-4mrmA:
undetectable
3u9fK-4mrmA:
undetectable		 3u9fJ-4mrmA:
19.66
3u9fK-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 10 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.23A 3u9fR-4mrmA:
undetectable		 3u9fR-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		3 / 3 TYR B 285
MET B 272
LEU B 201
 None
 0.93A 3vw1D-4mrmB:
undetectable		 3vw1D-4mrmB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		3 / 3 TYR B 277
ASP B 247
ASP B 228
 None
 0.85A 4a6eA-4mrmB:
undetectable		 4a6eA-4mrmB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 5 HIS B 355
GLY B 356
TYR B 359
GLU B 341
 None
 1.44A 4ae1B-4mrmB:
undetectable		 4ae1B-4mrmB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY A 268
GLY A 304
TYR A 430
GLU A 303
 None
 0.89A 4fgzB-4mrmA:
undetectable		 4fgzB-4mrmA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		5 / 12 VAL B 134
PHE B 354
VAL B  77
SER B  72
GLY B  74
 None
 1.10A 4mm6A-4mrmB:
undetectable		 4mm6A-4mrmB:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 8 TRP A  65
SER A 130
SER A 153
HIS A 170
GLU A 349
 2BY  A 501 (-3.6A)
2BY  A 501 (-3.0A)
2BY  A 501 (-2.6A)
2BY  A 501 (-4.1A)
2BY  A 501 (-3.5A)
 0.22A 4ms4A-4mrmA:
58.0		 4ms4A-4mrmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 6 LEU A  79
ASN A  83
MET A 126
LEU A 360
ILE A  88
 None
 1.36A 4okxA-4mrmA:
undetectable		 4okxA-4mrmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		5 / 9 ALA B 120
ALA B 116
LEU B 114
LEU B  61
VAL B 130
 None
 1.11A 4or0B-4mrmB:
undetectable		 4or0B-4mrmB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens) 		4 / 8 LEU B 219
THR B 200
LEU B 252
LEU B 215
 None
 0.76A 4z90F-4mrmB:
undetectable
4z90G-4mrmB:
undetectable
4z90H-4mrmB:
undetectable
4z90I-4mrmB:
undetectable
4z90J-4mrmB:
undetectable		 4z90F-4mrmB:
20.86
4z90G-4mrmB:
20.86
4z90H-4mrmB:
20.86
4z90I-4mrmB:
20.86
4z90J-4mrmB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 6 PRO A 120
GLU A  80
ALA A 361
LEU A 360
 None
 1.06A 5igiA-4mrmA:
undetectable		 5igiA-4mrmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA A 139
ALA A  74
THR A 169
LEU A 148
THR A 134
 None
 1.15A 5tl8A-4mrmA:
undetectable		 5tl8A-4mrmA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens) 		4 / 5 ARG A 336
ALA A  74
TYR A 354
ILE A 357
 None
 1.27A 6g9bA-4mrmA:
0.2
6g9bB-4mrmA:
undetectable		 6g9bA-4mrmA:
12.23
6g9bB-4mrmA:
12.79