SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 520
LEU A 437
ILE A 392
PRO A 359
VAL A 356
 None
 1.36A 1hrkB-4mrpA:
undetectable		 1hrkB-4mrpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 TYR A  87
LEU A  54
THR A 309
ARG A 313
 None
 1.27A 1i2wA-4mrpA:
undetectable		 1i2wA-4mrpA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 8 LEU A 582
VAL A 393
GLY A 394
GLU A 575
 None
 1.06A 1jlfA-4mrpA:
undetectable
1jlfB-4mrpA:
2.3		 1jlfA-4mrpA:
21.28
1jlfB-4mrpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 GLU A 490
THR A 489
LEU A 498
 None
 0.63A 1v8bC-4mrpA:
undetectable		 1v8bC-4mrpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 ALA A  59
TYR A  60
ALA A  86
TYR A  87
 None
 1.06A 1xl6A-4mrpA:
2.4
1xl6B-4mrpA:
3.9		 1xl6A-4mrpA:
20.90
1xl6B-4mrpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 LEU A 354
SER A 432
THR A 429
VAL A 428
 None
 1.10A 2uz2A-4mrpA:
undetectable		 2uz2A-4mrpA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 492
GLY A 495
ARG A 494
THR A 489
GLU A 490
 None
 1.12A 2vdvE-4mrpA:
undetectable		 2vdvE-4mrpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A 492
GLY A 495
ARG A 494
THR A 489
GLU A 490
 None
 1.11A 2vdvF-4mrpA:
undetectable		 2vdvF-4mrpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 588
TYR A 589
GLY A 577
ASP A 569
LEU A 568
 None
 1.27A 3ou7D-4mrpA:
undetectable		 3ou7D-4mrpA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 LEU A 311
MET A 280
PHE A 176
ASN A 305
 None
 1.39A 3uq6A-4mrpA:
undetectable		 3uq6A-4mrpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 520
LEU A 437
ILE A 392
PRO A 359
VAL A 356
 None
 1.41A 3w1wB-4mrpA:
undetectable		 3w1wB-4mrpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 PHE A  23
GLY A 109
THR A 113
ILE A 151
 None
None
None
LDA  A 701 ( 4.7A)
 0.81A 4ejjA-4mrpA:
undetectable		 4ejjA-4mrpA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 ASP A 111
ARG A 107
ASP A  31
 None
 0.55A 4fp9A-4mrpA:
undetectable		 4fp9A-4mrpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 ASP A 111
ARG A 107
ASP A  31
 None
 0.62A 4fp9C-4mrpA:
undetectable		 4fp9C-4mrpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 ASP A 111
ARG A 107
ASP A  31
 None
 0.58A 4fp9F-4mrpA:
undetectable		 4fp9F-4mrpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 ALA A 594
ALA A 597
ALA A 598
ALA A 601
 None
 0.10A 4oadA-4mrpA:
undetectable		 4oadA-4mrpA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4mrp ABC TRANSPORTER
RELATED PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 ALA A 594
ALA A 597
ALA A 598
ALA A 601
 None
 0.12A 4oaeA-4mrpA:
undetectable		 4oaeA-4mrpA:
14.59