SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mrq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 7 GLY A 185
GLN A 190
VAL A 183
PRO A  86
None
1.08A 1rxcD-4mrqA:
undetectable
1rxcD-4mrqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 4 LEU A 429
SER A 384
LEU A 392
LEU A 452
None
0.95A 1yajA-4mrqA:
undetectable
1yajA-4mrqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 5 LEU A 429
SER A 384
LEU A 392
LEU A 452
None
0.97A 1yajD-4mrqA:
undetectable
1yajD-4mrqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 7 THR A 106
VAL A 183
GLY A 182
ASP A 246
None
None
None
ZN  A 501 ( 2.3A)
0.91A 2a1mA-4mrqA:
undetectable
2a1mA-4mrqA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 4 VAL A  53
LEU A 143
ILE A 138
LEU A 134
None
0.97A 2byoA-4mrqA:
undetectable
2byoA-4mrqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 8 ARG A  15
GLY A  21
THR A  31
ILE A  35
TLA  A 502 (-4.1A)
None
None
None
0.93A 2f9wA-4mrqA:
undetectable
2f9wB-4mrqA:
undetectable
2f9wA-4mrqA:
21.43
2f9wB-4mrqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
3 / 3 LYS A 285
GLY A 218
PRO A 217
None
0.76A 2hreB-4mrqA:
undetectable
2hreB-4mrqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
3 / 3 VAL A 271
ASP A 270
GLU A 334
None
PGE  A 509 ( 4.9A)
None
0.70A 2qeuA-4mrqA:
undetectable
2qeuA-4mrqA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
3 / 3 VAL A 271
ASP A 270
GLU A 334
None
PGE  A 509 ( 4.9A)
None
0.71A 2qeuC-4mrqA:
undetectable
2qeuC-4mrqA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 10 ILE A  69
LEU A  72
VAL A 103
GLY A 102
GLY A  54
None
1.24A 2wd9C-4mrqA:
undetectable
2wd9C-4mrqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 10 VAL A 103
ILE A 119
LEU A 143
LEU A 134
ARG A 137
None
0.98A 2xf3A-4mrqA:
undetectable
2xf3A-4mrqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 4 LEU A 459
ARG A 394
LEU A 392
ALA A 387
None
1.16A 3b9mA-4mrqA:
undetectable
3b9mA-4mrqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 102
VAL A  96
LEU A  97
ILE A 119
LEU A  68
None
PEG  A 507 (-4.3A)
None
None
None
0.86A 3cjtC-4mrqA:
undetectable
3cjtC-4mrqA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 PHE A 332
LEU A 266
LEU A 349
SER A 345
ILE A 352
None
PGE  A 509 (-4.9A)
None
None
None
1.18A 3ko0M-4mrqA:
undetectable
3ko0N-4mrqA:
undetectable
3ko0O-4mrqA:
undetectable
3ko0P-4mrqA:
undetectable
3ko0M-4mrqA:
12.13
3ko0N-4mrqA:
12.13
3ko0O-4mrqA:
12.13
3ko0P-4mrqA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 ASP A 244
ASP A 246
HIS A 329
ALA A 184
PHE A 241
ZN  A 501 ( 2.5A)
ZN  A 501 ( 2.3A)
TLA  A 502 (-4.0A)
None
None
1.40A 3r2jC-4mrqA:
undetectable
3r2jC-4mrqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 VAL A 153
TRP A 336
VAL A  89
ALA A  93
LEU A  97
None
1.06A 3rr3A-4mrqA:
undetectable
3rr3A-4mrqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 VAL A 153
TRP A 336
VAL A  89
ALA A  93
LEU A  97
None
1.06A 3rr3B-4mrqA:
undetectable
3rr3B-4mrqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
3 / 3 LEU A 156
MET A  84
ASP A 244
None
None
ZN  A 501 ( 2.5A)
0.90A 3v5wA-4mrqA:
undetectable
3v5wA-4mrqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
3 / 3 ASP A 207
VAL A 186
ASN A 212
None
0.72A 4lmnA-4mrqA:
2.2
4lmnA-4mrqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 418
GLY A 399
ILE A 444
VAL A 409
ILE A 403
None
0.99A 4q5mA-4mrqA:
undetectable
4q5mA-4mrqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 TYR A 259
HIS A 329
GLY A 328
ASP A 244
GLY A 245
PEG  A 504 ( 4.2A)
TLA  A 502 (-4.0A)
None
ZN  A 501 ( 2.5A)
None
1.29A 4qa0A-4mrqA:
undetectable
4qa0A-4mrqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 TYR A 259
HIS A 329
GLY A 328
ASP A 244
GLY A 245
PEG  A 504 ( 4.2A)
TLA  A 502 (-4.0A)
None
ZN  A 501 ( 2.5A)
None
1.23A 4qa2A-4mrqA:
undetectable
4qa2A-4mrqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 TYR A 259
HIS A 329
GLY A 328
ASP A 244
GLY A 245
PEG  A 504 ( 4.2A)
TLA  A 502 (-4.0A)
None
ZN  A 501 ( 2.5A)
None
1.18A 4qa2B-4mrqA:
undetectable
4qa2B-4mrqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 LEU A   9
LEU A  68
GLY A  36
ALA A  38
LEU A 143
None
0.99A 4rrwC-4mrqA:
undetectable
4rrwC-4mrqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 LEU A   9
LEU A  68
GLY A  36
ALA A  38
LEU A 143
None
0.99A 4rrzC-4mrqA:
undetectable
4rrzC-4mrqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 7 ILE A  19
LEU A 126
ALA A  38
ILE A  35
None
0.80A 4y03A-4mrqA:
undetectable
4y03A-4mrqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 8 SER A 101
ALA A 122
PRO A  49
LEU A  44
None
0.99A 5dzkd-4mrqA:
undetectable
5dzkr-4mrqA:
undetectable
5dzkd-4mrqA:
19.43
5dzkr-4mrqA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 8 SER A 101
ALA A 122
PRO A  49
LEU A  44
None
1.07A 5dzkF-4mrqA:
undetectable
5dzkT-4mrqA:
undetectable
5dzkF-4mrqA:
19.43
5dzkT-4mrqA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 ALA A 188
HIS A 213
PHE A 241
GLY A 180
TYR A 203
None
0.68A 5hfjB-4mrqA:
undetectable
5hfjB-4mrqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 6 ARG A 262
PRO A 260
ARG A 432
THR A 287
None
None
PEG  A 504 (-4.0A)
None
1.37A 5ih0A-4mrqA:
undetectable
5ih0A-4mrqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 VAL A 153
TRP A 336
VAL A  89
ALA A  93
LEU A  97
None
1.04A 5iktA-4mrqA:
undetectable
5iktA-4mrqA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 9 LEU A 237
VAL A 177
LEU A 239
PRO A 189
ALA A 188
None
1.28A 5og9A-4mrqA:
undetectable
5og9A-4mrqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 4 PHE A 332
LEU A 293
LEU A 264
VAL A 272
None
1.10A 5xxiA-4mrqA:
undetectable
5xxiA-4mrqA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 9 VAL A  65
VAL A  82
LEU A  68
GLY A 102
VAL A  79
None
1.22A 6czmB-4mrqA:
undetectable
6czmC-4mrqA:
undetectable
6czmB-4mrqA:
22.10
6czmC-4mrqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 10 VAL A  65
VAL A  82
LEU A  68
GLY A 102
VAL A  79
None
1.24A 6czmE-4mrqA:
undetectable
6czmF-4mrqA:
undetectable
6czmE-4mrqA:
22.10
6czmF-4mrqA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
4 / 6 ASP A 412
ARG A 288
GLU A 434
ASP A 370
None
1.44A 6mn5D-4mrqA:
undetectable
6mn5D-4mrqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 ASP A  18
SER A 309
HIS A 329
ASP A 242
ASP A 244
TLA  A 502 ( 4.8A)
None
TLA  A 502 (-4.0A)
ZN  A 501 ( 2.3A)
ZN  A 501 ( 2.5A)
1.27A 6n91A-4mrqA:
undetectable
6n91A-4mrqA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa)
5 / 12 ASP A  18
SER A 309
HIS A 329
ASP A 242
ASP A 244
TLA  A 502 ( 4.8A)
None
TLA  A 502 (-4.0A)
ZN  A 501 ( 2.3A)
ZN  A 501 ( 2.5A)
1.26A 6n91B-4mrqA:
undetectable
6n91B-4mrqA:
9.91