SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ARG A 458
TYR A 148
ASP A 517
TYR A 487
TYR A  92
 None
 1.50A 1mxfA-4mruA:
undetectable		 1mxfA-4mruA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A  88
GLU A  83
TYR A 281
 None
 1.15A 2a3aA-4mruA:
undetectable		 2a3aA-4mruA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A 226
LYS A 248
VAL A 250
 EDO  A 603 (-2.8A)
None
None
 0.81A 2jfaB-4mruA:
undetectable		 2jfaB-4mruA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  57
VAL A 523
ILE A 151
ARG A 459
 None
 1.00A 3ik3B-4mruA:
undetectable		 3ik3B-4mruA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 290
TYR A 294
TYR A 394
PHE A 383
 None
 1.17A 3ku9B-4mruA:
undetectable		 3ku9B-4mruA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 376
GLY A 378
PHE A 383
ALA A 445
GLN A 441
 MG  A 601 ( 4.7A)
None
None
None
None
 1.09A 3nvkF-4mruA:
undetectable
3nvkJ-4mruA:
undetectable		 3nvkF-4mruA:
21.57
3nvkJ-4mruA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 376
TYR A 394
PHE A 383
ALA A 445
GLN A 441
 MG  A 601 ( 4.7A)
None
None
None
None
 1.17A 3nvkF-4mruA:
undetectable
3nvkJ-4mruA:
undetectable		 3nvkF-4mruA:
21.57
3nvkJ-4mruA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 290
LEU A 338
ARG A 299
 None
 0.81A 3sufB-4mruA:
undetectable		 3sufB-4mruA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 136
LEU A 132
LEU A 222
MET A 348
 None
 0.86A 3vhuA-4mruA:
undetectable		 3vhuA-4mruA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 233
PHE A 183
ALA A 249
SER A 455
ASP A 146
 None
None
EDO  A 603 (-3.8A)
None
None
 1.31A 4aqlA-4mruA:
undetectable		 4aqlA-4mruA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 302
HIS A 386
ARG A 298
 None
 1.21A 4e7bC-4mruA:
undetectable		 4e7bC-4mruA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 129
PRO A 127
TYR A  45
LEU A  47
 None
 0.97A 4iomA-4mruA:
undetectable		 4iomA-4mruA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A  82
GLY A  79
LEU A 465
LEU A 466
 None
None
EDO  A 605 ( 3.8A)
None
 0.82A 4mwzB-4mruA:
undetectable		 4mwzB-4mruA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 474
THR A 518
ASP A 517
TYR A 492
 None
 1.16A 4oltB-4mruA:
undetectable		 4oltB-4mruA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 474
THR A 518
ASP A 517
TYR A 492
 None
 1.48A 4oltB-4mruA:
undetectable		 4oltB-4mruA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 221
LEU A 135
GLY A  56
LEU A  57
VAL A 109
 None
 1.13A 4wnwA-4mruA:
undetectable		 4wnwA-4mruA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 406
SER A 333
TYR A 334
 None
 0.73A 5glmA-4mruA:
undetectable		 5glmA-4mruA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 337
THR A 340
ALA A 272
ASP A 343
 None
 1.29A 5mfxA-4mruA:
undetectable		 5mfxA-4mruA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 GLU A  70
TYR A  66
TYR A 345
ARG A 143
 None
 1.28A 5mthA-4mruA:
undetectable
5mthB-4mruA:
undetectable		 5mthA-4mruA:
18.80
5mthB-4mruA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 GLU A  70
TYR A  66
TYR A 345
ARG A 143
 None
 1.27A 5mthH-4mruA:
undetectable
5mthL-4mruA:
undetectable		 5mthH-4mruA:
18.80
5mthL-4mruA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 421
PRO A 401
GLY A 293
TYR A 290
 None
 1.43A 5x80A-4mruA:
undetectable
5x80B-4mruA:
undetectable		 5x80A-4mruA:
14.75
5x80B-4mruA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 459
PHE A 431
ARG A 363
 None
 1.21A 5y9yA-4mruA:
undetectable		 5y9yA-4mruA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 106
ASP A 108
LYS A 103
 None
 0.85A 6awtD-4mruA:
undetectable		 6awtD-4mruA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 458
PRO A 150
GLN A 175
ILE A 147
 None
 1.07A 6ef6A-4mruA:
undetectable		 6ef6A-4mruA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4mru SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A 439
LEU A 435
ARG A 228
MET A 231
 None
None
EDO  A 604 (-3.1A)
None
 1.04A 6nmfN-4mruA:
0.4
6nmfW-4mruA:
undetectable		 6nmfN-4mruA:
19.65
6nmfW-4mruA:
8.86