SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.90A 1c6zA-4msoA:
undetectable		 1c6zA-4msoA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		6 / 12 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ALA A 297
ILE A 307
 None
 1.15A 1rl8A-4msoA:
undetectable		 1rl8A-4msoA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 305
LEU A 321
LEU A 318
LEU A 362
 None
 1.04A 2ab2B-4msoA:
undetectable		 2ab2B-4msoA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 174
ALA A 179
ASP A 201
ALA A 175
TYR A 205
 None
 1.34A 2avdB-4msoA:
2.8		 2avdB-4msoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		4 / 8 GLY A 105
ALA A 109
ASN A  93
ILE A 250
 None
 0.83A 2dtjA-4msoA:
undetectable
2dtjB-4msoA:
undetectable		 2dtjA-4msoA:
19.63
2dtjB-4msoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 170
GLY A 147
ALA A 163
ILE A 190
LEU A 187
 None
 0.83A 3adxB-4msoA:
undetectable		 3adxB-4msoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.90A 3k4vC-4msoA:
undetectable		 3k4vC-4msoA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.88A 3nduC-4msoA:
undetectable		 3nduC-4msoA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.93A 3ndwA-4msoA:
undetectable		 3ndwA-4msoA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.92A 3pwrB-4msoA:
undetectable		 3pwrB-4msoA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.93A 3tkgD-4msoA:
undetectable		 3tkgD-4msoA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		4 / 5 ALA A 385
ILE A 326
LEU A 321
LYS A 324
 None
 1.20A 4g19A-4msoA:
undetectable		 4g19A-4msoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 9 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.98A 4ll3B-4msoA:
undetectable		 4ll3B-4msoA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 11 ARG A 294
ASP A 320
VAL A 319
GLY A 304
ILE A 307
 None
 0.97A 4njvB-4msoA:
undetectable		 4njvB-4msoA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		4 / 5 THR A 227
THR A 226
HIS A 315
ASN A  38
 PO4  A 501 (-4.1A)
None
None
None
 1.41A 4pgfB-4msoA:
3.6		 4pgfB-4msoA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A  37
THR A 227
HIS A 229
 None
PO4  A 501 (-4.1A)
PO4  A 501 (-4.1A)
 0.87A 4q15B-4msoA:
undetectable		 4q15B-4msoA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 9 ALA A 268
ALA A  47
ALA A  43
SER A  41
ALA A 271
 None
 1.29A 4twdA-4msoA:
undetectable
4twdB-4msoA:
undetectable
4twdC-4msoA:
undetectable
4twdD-4msoA:
undetectable
4twdE-4msoA:
undetectable		 4twdA-4msoA:
21.22
4twdB-4msoA:
21.22
4twdC-4msoA:
21.22
4twdD-4msoA:
21.22
4twdE-4msoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 187
TYR A 156
GLY A 119
SER A 121
LEU A 148
 None
 1.38A 4zbrA-4msoA:
2.4		 4zbrA-4msoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 10 PHE A 282
ALA A 277
LEU A 208
PHE A  87
THR A 226
 None
 1.33A 4zmeB-4msoA:
undetectable		 4zmeB-4msoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A 222
ALA A 221
GLN A  85
GLY A  88
GLU A  90
 None
 1.41A 5hfjC-4msoA:
undetectable		 5hfjC-4msoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A 198
ALA A 173
ILE A 117
LEU A 170
 None
 0.86A 5te8A-4msoA:
undetectable		 5te8A-4msoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4mso SERINE
HYDROXYMETHYLTRANSFE
RASE
(Burkholderia
cenocepacia) 		4 / 7 PHE A 184
ARG A 186
LEU A 187
ALA A 173
 None
 1.24A 6b89A-4msoA:
undetectable		 6b89A-4msoA:
13.82