SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		4 / 7 SER A 170
TYR A 173
ASN A 172
TYR A 175
 None
 0.99A 1dssG-4mstA:
undetectable		 1dssG-4mstA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		4 / 8 SER A 170
TYR A 173
ASN A 172
TYR A 175
 None
 0.99A 1dssR-4mstA:
undetectable		 1dssR-4mstA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		5 / 12 PHE A 110
GLY A 163
GLY A 179
LEU A 186
LEU A 184
 None
 1.09A 2hw2A-4mstA:
undetectable		 2hw2A-4mstA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		5 / 12 PHE A 111
LEU A  65
ALA A  83
PHE A 201
SER A 200
 None
 1.38A 3apwB-4mstA:
undetectable		 3apwB-4mstA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		4 / 8 SER A 170
TYR A 173
ASN A 172
TYR A 175
 None
 1.01A 3dmtC-4mstA:
undetectable		 3dmtC-4mstA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		4 / 7 TYR A 146
GLU A 253
GLN A 168
PRO A 291
 None
 1.20A 3ugrA-4mstA:
undetectable		 3ugrA-4mstA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		4 / 5 ILE A  56
PHE A  78
SER A  59
ASP A  82
 None
 1.29A 4rzvB-4mstA:
undetectable		 4rzvB-4mstA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		4 / 7 ILE A 205
ILE A  85
THR A  96
PHE A 110
 None
 0.79A 5fukA-4mstA:
undetectable
5fukB-4mstA:
undetectable		 5fukA-4mstA:
20.44
5fukB-4mstA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4mst CLASS I CHITINASE
(Hevea
brasiliensis) 		5 / 12 GLY A 240
VAL A 243
PHE A 292
THR A 229
GLY A 230
 None
 0.92A 6brdB-4mstA:
undetectable		 6brdB-4mstA:
15.19