SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 ASP A 422
LEU A 421
GLY A 419
PHE A 210
ALA A 426
 None
 1.49A 1ju6C-4mt0A:
undetectable		 1ju6C-4mt0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 ASP A  51
ASP A 280
LYS A 460
 None
 1.10A 1lqtB-4mt0A:
undetectable		 1lqtB-4mt0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 ASP A  51
ASP A 280
LYS A 460
 None
 1.12A 1lquB-4mt0A:
undetectable		 1lquB-4mt0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 ASP A  68
HIS A 162
LEU A 459
TRP A  54
 None
 1.19A 1pk2A-4mt0A:
undetectable		 1pk2A-4mt0A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 ASP A 283
ASP A 159
GLY A 458
GLY A 457
LEU A 455
 None
 1.00A 3em4V-4mt0A:
undetectable		 3em4V-4mt0A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 193
PRO A 216
TYR A 413
 None
 0.99A 5tzoB-4mt0A:
undetectable		 5tzoB-4mt0A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 THR A  22
PHE A 137
ARG A 141
ASP A 135
 None
 1.24A 5uxcA-4mt0A:
undetectable		 5uxcA-4mt0A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 ALA A 153
GLY A 150
TYR A 151
TYR A  91
 None
 1.01A 5uxdA-4mt0A:
undetectable		 5uxdA-4mt0A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 TYR A 452
LEU A 163
ASP A 283
 None
 0.87A 5zv2B-4mt0A:
undetectable		 5zv2B-4mt0A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 LEU A 258
GLU A 181
LEU A 260
LEU A  63
 None
 1.22A 6cbzA-4mt0A:
undetectable		 6cbzA-4mt0A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4mt0 MTRE PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 TYR A 367
ALA A 374
LEU A 278
 None
 0.66A 6d9kF-4mt0A:
undetectable		 6d9kF-4mt0A:
21.60