SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 ILE A 951
VAL A 452
GLY A 442
LEU A 888
 None
 1.00A 1dzmA-4mt1A:
undetectable		 1dzmA-4mt1A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 7 SER A 752
PRO A  50
ALA A  52
TYR A  49
SER A 754
 None
 1.27A 1k5qA-4mt1A:
1.2
1k5qB-4mt1A:
undetectable		 1k5qA-4mt1A:
11.48
1k5qB-4mt1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 PRO A 562
GLU A 564
PHE A 929
ARG A1008
 None
 1.32A 1oniA-4mt1A:
undetectable
1oniC-4mt1A:
undetectable		 1oniA-4mt1A:
8.14
1oniC-4mt1A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 GLY A 938
VAL A 937
LEU A 454
LEU A 873
TYR A 874
 None
 1.12A 1pbcA-4mt1A:
undetectable		 1pbcA-4mt1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.76A 1usqA-4mt1A:
undetectable		 1usqA-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.77A 1usqB-4mt1A:
undetectable		 1usqB-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.77A 1usqC-4mt1A:
undetectable		 1usqC-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.77A 1usqD-4mt1A:
undetectable		 1usqD-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.78A 1usqE-4mt1A:
undetectable		 1usqE-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 406
GLU A 955
ARG A 416
 None
 0.71A 1wopA-4mt1A:
3.5		 1wopA-4mt1A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 9 LEU A 308
GLU A 168
SER A 328
GLU A 306
ALA A 309
 None
 1.24A 1wrlA-4mt1A:
0.0
1wrlB-4mt1A:
0.4		 1wrlA-4mt1A:
7.08
1wrlB-4mt1A:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 9 LEU A 308
GLU A 168
SER A 328
GLU A 306
ALA A 309
 None
 1.21A 1wrlE-4mt1A:
0.6
1wrlF-4mt1A:
0.0		 1wrlE-4mt1A:
7.08
1wrlF-4mt1A:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 795
LEU A 798
ILE A 743
ILE A 738
SER A 792
 None
 1.15A 1xdkB-4mt1A:
undetectable		 1xdkB-4mt1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 11 VAL A 531
GLU A 525
ALA A 975
ILE A 982
PRO A1030
 None
 1.30A 2admB-4mt1A:
undetectable		 2admB-4mt1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 LEU A 391
LEU A 561
ILE A 667
ALA A 461
 None
 0.77A 2i2zA-4mt1A:
undetectable		 2i2zA-4mt1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.84A 2jkjA-4mt1A:
undetectable		 2jkjA-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.84A 2jkjB-4mt1A:
undetectable		 2jkjB-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.84A 2jkjC-4mt1A:
undetectable		 2jkjC-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.79A 2jklA-4mt1A:
undetectable		 2jklA-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.80A 2jklB-4mt1A:
undetectable		 2jklB-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.79A 2jklC-4mt1A:
undetectable		 2jklC-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.80A 2jklD-4mt1A:
undetectable		 2jklD-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 GLY A  51
PRO A  50
ILE A  48
GLY A  86
 None
 0.80A 2jklF-4mt1A:
undetectable		 2jklF-4mt1A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 SER A  33
ALA A 297
ASN A 296
ALA A 299
SER A 328
 None
 1.33A 2r2vC-4mt1A:
undetectable
2r2vF-4mt1A:
undetectable
2r2vG-4mt1A:
undetectable		 2r2vC-4mt1A:
6.25
2r2vF-4mt1A:
6.25
2r2vG-4mt1A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 SER A1025
VAL A1026
PHE A 517
ILE A 983
PHE A 979
 None
 1.43A 2vdyA-4mt1A:
undetectable		 2vdyA-4mt1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 PHE A 626
ALA A 639
ALA A 643
THR A 647
 None
 0.85A 2wx2A-4mt1A:
undetectable		 2wx2A-4mt1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 PHE A 626
ALA A 639
ALA A 643
THR A 647
 None
 0.83A 2wx2B-4mt1A:
undetectable		 2wx2B-4mt1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 THR A 277
PHE A 610
SER A 615
SER A  85
GLY A 177
 None
 1.49A 2x2iD-4mt1A:
undetectable		 2x2iD-4mt1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 115
VAL A 114
VAL A 129
LEU A  92
LEU A  62
 None
 1.23A 2zlcA-4mt1A:
1.5		 2zlcA-4mt1A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 974
ILE A 953
LEU A 952
VAL A 409
ILE A 436
 None
 1.34A 3adsB-4mt1A:
undetectable		 3adsB-4mt1A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 TYR A 383
ILE A  27
LEU A 375
GLY A 376
GLY A 377
 None
 1.02A 3axzA-4mt1A:
undetectable		 3axzA-4mt1A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 945
GLY A 944
SER A 946
LEU A 447
PHE A 451
 None
 1.11A 3e23A-4mt1A:
undetectable		 3e23A-4mt1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 ARG A  67
PRO A 119
GLY A  59
MET A  57
 None
 1.09A 3hcrA-4mt1A:
undetectable		 3hcrA-4mt1A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		6 / 12 GLY A 609
SER A 274
LYS A 581
GLY A 616
SER A 615
GLY A 614
 None
 1.41A 3hlwB-4mt1A:
undetectable		 3hlwB-4mt1A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 PHE A 626
ALA A 639
ALA A 643
THR A 647
 None
 0.82A 3khmA-4mt1A:
undetectable		 3khmA-4mt1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 PHE A 481
GLY A  23
PHE A  11
PHE A   5
 None
 1.11A 3ko0K-4mt1A:
undetectable
3ko0S-4mt1A:
undetectable		 3ko0K-4mt1A:
7.01
3ko0S-4mt1A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 PHE A 176
ILE A 167
THR A 327
ARG A 174
 None
 1.15A 3nxuA-4mt1A:
undetectable		 3nxuA-4mt1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 PHE A 935
GLY A 905
PHE A 553
ILE A 907
GLY A1017
 None
 1.34A 3ps9A-4mt1A:
undetectable		 3ps9A-4mt1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 GLN A 574
THR A 584
ASN A 618
 None
 0.91A 3v4tE-4mt1A:
undetectable		 3v4tE-4mt1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 ILE A 982
TYR A 524
HIS A 522
PHE A1027
 None
 1.06A 4a97H-4mt1A:
0.0		 4a97H-4mt1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 SER A1025
VAL A1026
PHE A 517
ILE A 983
PHE A 979
 None
 1.45A 4c49B-4mt1A:
undetectable		 4c49B-4mt1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 SER A1025
VAL A1026
PHE A 517
ILE A 983
PHE A 979
 None
 1.41A 4c49C-4mt1A:
undetectable		 4c49C-4mt1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 ALA A 461
PHE A 935
THR A1013
VAL A 942
 None
 1.02A 4ltwA-4mt1A:
undetectable		 4ltwA-4mt1A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 TYR A  49
SER A 752
ALA A  52
SER A  53
 None
 1.20A 4lv9A-4mt1A:
undetectable
4lv9B-4mt1A:
undetectable		 4lv9A-4mt1A:
18.19
4lv9B-4mt1A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 SER A 721
LEU A 718
LEU A 692
ASN A 618
 None
 1.08A 4n09B-4mt1A:
undetectable		 4n09B-4mt1A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 GLY A 281
VAL A 282
THR A 277
MET A 141
SER A 143
 None
 1.31A 4yb6A-4mt1A:
4.0
4yb6E-4mt1A:
4.2		 4yb6A-4mt1A:
14.02
4yb6E-4mt1A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 GLY A 281
VAL A 282
THR A 277
MET A 141
SER A 143
 None
 1.33A 4yb6C-4mt1A:
4.1
4yb6F-4mt1A:
4.2		 4yb6C-4mt1A:
14.02
4yb6F-4mt1A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 MET A 141
SER A 143
GLY A 281
VAL A 282
THR A 277
 None
 1.34A 4yb6A-4mt1A:
4.0
4yb6D-4mt1A:
3.9		 4yb6A-4mt1A:
14.02
4yb6D-4mt1A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 MET A 141
SER A 143
GLY A 281
VAL A 282
THR A 277
 None
 1.33A 4yb6D-4mt1A:
3.9
4yb6E-4mt1A:
4.2		 4yb6D-4mt1A:
14.02
4yb6E-4mt1A:
14.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 SER A  79
MET A 570
PHE A 610
PHE A 612
GLY A 857
 None
 1.21A 4zjlA-4mt1A:
50.8		 4zjlA-4mt1A:
49.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 SER A  89
THR A  44
SER A 134
ILE A 139
PHE A 623
 None
 1.19A 4zjqD-4mt1A:
51.4		 4zjqD-4mt1A:
49.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 SER A 711
GLY A 673
GLU A 669
ARG A 714
 None
 1.12A 5cdqA-4mt1A:
2.9
5cdqB-4mt1A:
undetectable
5cdqC-4mt1A:
undetectable		 5cdqA-4mt1A:
18.45
5cdqB-4mt1A:
11.89
5cdqC-4mt1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 992
VAL A 450
GLY A 401
ASP A 405
LEU A 991
 None
 1.02A 5hg0A-4mt1A:
undetectable		 5hg0A-4mt1A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 992
VAL A 450
GLY A 401
ASP A 405
LEU A 991
 None
 1.01A 5hg0B-4mt1A:
undetectable		 5hg0B-4mt1A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ALA A  22
PHE A  25
GLY A  26
SER A  29
PRO A  31
 None
 0.76A 5jglA-4mt1A:
undetectable		 5jglA-4mt1A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 SER A 611
ALA A 620
GLN A 617
THR A 584
 None
 1.23A 5n0tA-4mt1A:
undetectable		 5n0tA-4mt1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 LEU A 906
ALA A 909
ALA A 910
THR A 914
 None
 0.56A 6a7jA-4mt1A:
undetectable		 6a7jA-4mt1A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 9 ASN A 296
ILE A 381
SER A  33
GLY A  26
THR A 471
 None
 1.34A 6awpA-4mt1A:
1.7		 6awpA-4mt1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		5 / 9 ALA A 480
VAL A 403
VAL A 369
SER A 373
GLY A 376
 None
 1.15A 6bklA-4mt1A:
undetectable
6bklB-4mt1A:
undetectable
6bklC-4mt1A:
undetectable
6bklD-4mt1A:
undetectable		 6bklA-4mt1A:
2.56
6bklB-4mt1A:
2.56
6bklC-4mt1A:
2.56
6bklD-4mt1A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 SER A 893
SER A 891
ALA A 962
 None
 0.71A 6dwnC-4mt1A:
undetectable		 6dwnC-4mt1A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4mt1 DRUG EFFLUX PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 405
SER A 373
SER A 475
 None
 0.70A 6mxtA-4mt1A:
0.0		 6mxtA-4mt1A:
18.27