SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		3 / 3 TYR A 201
ARG A  70
GLN A 259
 None
 0.92A 1tw4A-4mt6A:
undetectable		 1tw4A-4mt6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.06A 1v54A-4mt6A:
undetectable
1v54J-4mt6A:
undetectable		 1v54A-4mt6A:
20.44
1v54J-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 8 PHE A 191
GLU A 122
GLN A 166
TYR A 201
 None
 1.47A 2aoxA-4mt6A:
undetectable		 2aoxA-4mt6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 ASP A 374
THR A 406
GLU A 408
GLU A 405
 None
 1.21A 2dttB-4mt6A:
undetectable
2dttC-4mt6A:
undetectable		 2dttB-4mt6A:
14.99
2dttC-4mt6A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.05A 2dyrA-4mt6A:
2.2
2dyrJ-4mt6A:
undetectable		 2dyrA-4mt6A:
20.44
2dyrJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.05A 2dysA-4mt6A:
2.1
2dysJ-4mt6A:
undetectable		 2dysA-4mt6A:
20.44
2dysJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.04A 2dysN-4mt6A:
undetectable
2dysW-4mt6A:
undetectable		 2dysN-4mt6A:
20.44
2dysW-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.03A 2eijA-4mt6A:
undetectable
2eijJ-4mt6A:
undetectable		 2eijA-4mt6A:
20.44
2eijJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.04A 2eilA-4mt6A:
1.9
2eilJ-4mt6A:
undetectable		 2eilA-4mt6A:
20.44
2eilJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 ASP A 374
ILE A 373
LEU A 401
GLU A 430
 None
 1.05A 2ya7A-4mt6A:
undetectable		 2ya7A-4mt6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 ASP A 374
ILE A 373
LEU A 401
GLU A 430
 None
 1.03A 2ya7B-4mt6A:
2.3		 2ya7B-4mt6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 ASP A 374
ILE A 373
LEU A 401
GLU A 430
 None
 1.05A 2ya7D-4mt6A:
undetectable		 2ya7D-4mt6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.08A 2zxwA-4mt6A:
2.3
2zxwJ-4mt6A:
undetectable		 2zxwA-4mt6A:
20.44
2zxwJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.03A 3abmA-4mt6A:
2.5
3abmJ-4mt6A:
undetectable		 3abmA-4mt6A:
20.44
3abmJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.01A 3asnA-4mt6A:
undetectable
3asnJ-4mt6A:
undetectable		 3asnA-4mt6A:
20.44
3asnJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 6 LEU A 209
TYR A 204
THR A 248
LEU A 247
 None
 1.01A 3asoA-4mt6A:
1.5
3asoJ-4mt6A:
undetectable		 3asoA-4mt6A:
20.44
3asoJ-4mt6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		3 / 3 VAL A  41
VAL A  69
TRP A  72
 None
 0.94A 3l8lC-4mt6A:
undetectable
3l8lD-4mt6A:
undetectable		 3l8lC-4mt6A:
6.01
3l8lD-4mt6A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		3 / 3 GLU A 299
GLU A 293
ASN A 292
 None
 0.87A 3lp9B-4mt6A:
2.2
3lp9D-4mt6A:
2.4		 3lp9B-4mt6A:
18.08
3lp9D-4mt6A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		5 / 10 PHE A 165
GLU A 122
PHE A 191
TYR A 256
PHE A 198
 None
 1.30A 3r6wA-4mt6A:
undetectable
3r6wB-4mt6A:
undetectable		 3r6wA-4mt6A:
18.74
3r6wB-4mt6A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		3 / 3 LYS A 400
VAL A 409
HIS A 402
 None
 1.01A 3tj7A-4mt6A:
undetectable		 3tj7A-4mt6A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9
(Rattus
norvegicus) 		4 / 5 ALA A 333
ILE A 335
LEU A 411
ASN A 342
 None
 1.07A 4g19A-4mt6A:
undetectable		 4g19A-4mt6A:
19.74