SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 122
ILE A 155
PHE A 152
LEU A 177
 None
 0.88A 1fslB-4mtkA:
undetectable		 1fslB-4mtkA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 577
VAL A 576
PHE A 592
ARG A 569
 None
 1.14A 3bjwF-4mtkA:
undetectable		 3bjwF-4mtkA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		3 / 3 PRO A  47
LEU A  48
GLN A  79
 SO4  A 708 (-4.3A)
SO4  A 708 (-3.5A)
SO4  A 708 ( 4.6A)
 0.72A 3hznG-4mtkA:
undetectable
3hznH-4mtkA:
undetectable		 3hznG-4mtkA:
15.32
3hznH-4mtkA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 112
LEU A 100
ARG A 107
ILE A 117
 SO4  A 713 (-4.0A)
None
SO4  A 709 (-3.1A)
None
 1.09A 3ln1C-4mtkA:
undetectable		 3ln1C-4mtkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 299
GLY A 290
SER A 342
LEU A 300
GLY A 298
 None
 1.04A 4blvB-4mtkA:
undetectable		 4blvB-4mtkA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 108
ARG A 157
ASP A 439
VAL A 390
 None
 1.24A 4nkxC-4mtkA:
undetectable		 4nkxC-4mtkA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 108
ARG A 157
ASP A 439
VAL A 390
 None
 1.26A 4nkxD-4mtkA:
undetectable		 4nkxD-4mtkA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 345
ARG A 246
ARG A 217
 None
 0.94A 4x5iA-4mtkA:
undetectable		 4x5iA-4mtkA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 178
PHE A 168
HIS A 175
GLU A 171
 None
 1.31A 5ad9A-4mtkA:
undetectable
5ad9B-4mtkA:
undetectable		 5ad9A-4mtkA:
19.94
5ad9B-4mtkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 293
VAL A 324
LEU A 344
VAL A 291
LEU A  60
 SO4  A 734 (-3.7A)
None
None
None
None
 1.11A 5ikqA-4mtkA:
undetectable		 5ikqA-4mtkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 5 SER A  41
VAL A  40
GLY A  88
ALA A  87
 None
 1.00A 5k50A-4mtkA:
undetectable		 5k50A-4mtkA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 341
ARG A 289
ARG A 323
ASP A 212
 SO4  A 745 ( 4.9A)
SO4  A 721 (-3.2A)
SO4  A 745 (-4.4A)
None
 0.75A 5zw4A-4mtkA:
undetectable		 5zw4A-4mtkA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4mtk VGRG1
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 466
TYR A 458
ASN A 463
 None
 0.99A 6dwdC-4mtkA:
undetectable		 6dwdC-4mtkA:
22.35