SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mtl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 ALA A  95
GLY A 120
PRO A 123
GLY A 124
LEU A 142
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
None
UNX  A1016 ( 2.9A)
SAH  A1001 (-4.2A)
 0.56A 1eizA-4mtlA:
11.6		 1eizA-4mtlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 ALA A  95
GLY A 120
PRO A 123
GLY A 124
LEU A 142
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
None
UNX  A1016 ( 2.9A)
SAH  A1001 (-4.2A)
 0.57A 1ej0A-4mtlA:
11.6		 1ej0A-4mtlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 6 LEU A 117
LEU A 149
LEU A 256
LEU A 246
 None
 0.94A 1errA-4mtlA:
undetectable		 1errA-4mtlA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 VAL A 210
LEU A 205
LEU A 206
PHE A 237
LEU A 234
 None
 1.25A 1kw0A-4mtlA:
undetectable		 1kw0A-4mtlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 VAL A 210
LEU A 205
LEU A 206
PHE A 237
LEU A 234
 None
 1.33A 1mmkA-4mtlA:
undetectable		 1mmkA-4mtlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 11 VAL A 210
LEU A 205
LEU A 206
PHE A 237
LEU A 234
 None
 1.29A 1mmtA-4mtlA:
undetectable		 1mmtA-4mtlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 5 ILE A 128
LEU A 149
ALA A 139
GLU A 118
 None
None
None
UNX  A1016 ( 2.6A)
 1.35A 1xvaA-4mtlA:
13.3
1xvaB-4mtlA:
13.1		 1xvaA-4mtlA:
24.28
1xvaB-4mtlA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 6 ALA A 139
GLU A 118
ILE A 116
LEU A 153
 None
UNX  A1016 ( 2.6A)
None
None
 1.02A 1xvaA-4mtlA:
13.3
1xvaB-4mtlA:
13.1		 1xvaA-4mtlA:
24.28
1xvaB-4mtlA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 GLU A 108
TYR A 101
LEU A  98
LEU A 191
TYR A 189
 None
 1.47A 2mjiA-4mtlA:
undetectable		 2mjiA-4mtlA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 ALA A  95
GLY A 120
PRO A 123
GLY A 124
LEU A 205
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
None
UNX  A1016 ( 2.9A)
None
 0.98A 2plwA-4mtlA:
12.2		 2plwA-4mtlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 GLY A 120
VAL A 190
LEU A 117
ASP A 194
LEU A 142
 SAH  A1001 (-3.6A)
None
None
None
SAH  A1001 (-4.2A)
 1.29A 3cjtK-4mtlA:
14.7		 3cjtK-4mtlA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 ALA A  95
GLY A 120
PRO A 123
GLY A 124
LEU A 142
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
None
UNX  A1016 ( 2.9A)
SAH  A1001 (-4.2A)
 0.54A 3douA-4mtlA:
11.0		 3douA-4mtlA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 7 ARG A 226
SER A 193
LEU A 202
ILE A 119
 UNX  A1003 ( 4.0A)
SAH  A1001 (-2.7A)
None
None
 1.08A 3ln1C-4mtlA:
undetectable		 3ln1C-4mtlA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 LEU A  98
VAL A 195
PHE A 257
LEU A 256
GLU A 118
 None
SAH  A1001 ( 4.9A)
None
None
UNX  A1016 ( 2.6A)
 1.16A 3medA-4mtlA:
undetectable
3medB-4mtlA:
undetectable		 3medA-4mtlA:
18.18
3medB-4mtlA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 8 GLU A 108
TYR A 189
LEU A 220
PHE A 111
 None
 1.15A 3rqwC-4mtlA:
undetectable
3rqwD-4mtlA:
undetectable		 3rqwC-4mtlA:
17.18
3rqwD-4mtlA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 8 GLU A 108
TYR A 189
LEU A 220
PHE A 111
 None
 1.12A 3rqwF-4mtlA:
undetectable
3rqwJ-4mtlA:
undetectable		 3rqwF-4mtlA:
17.18
3rqwJ-4mtlA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 6 GLY A 173
LEU A 176
ASN A 179
GLU A 169
 None
 0.99A 3zqtA-4mtlA:
undetectable		 3zqtA-4mtlA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 GLY A 120
ASP A 141
LEU A 142
TRP A 172
TYR A 197
 SAH  A1001 (-3.6A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.2A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.8A)
 1.06A 4lg1A-4mtlA:
24.9		 4lg1A-4mtlA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		8 / 12 TRP A  92
ALA A  95
GLY A 120
GLY A 122
ASP A 141
LEU A 142
TRP A 172
TYR A 197
 SAH  A1001 (-4.1A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.2A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.2A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.8A)
 0.30A 4lg1A-4mtlA:
24.9		 4lg1A-4mtlA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		7 / 12 TRP A  92
ALA A  95
GLY A 120
GLY A 122
LEU A 142
TRP A 172
TYR A 197
 SAH  A1001 (-4.1A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.2A)
SAH  A1001 (-4.2A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.8A)
 0.29A 4lg1B-4mtlA:
24.7		 4lg1B-4mtlA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 GLY A 120
ASP A 141
LEU A 142
TRP A 172
TYR A 197
 SAH  A1001 (-3.6A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.2A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.8A)
 1.06A 4lg1C-4mtlA:
24.8		 4lg1C-4mtlA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		8 / 12 TRP A  92
ALA A  95
GLY A 120
GLY A 122
ASP A 141
LEU A 142
TRP A 172
TYR A 197
 SAH  A1001 (-4.1A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.2A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.2A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.8A)
 0.33A 4lg1C-4mtlA:
24.8		 4lg1C-4mtlA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 ALA A  95
GLY A 122
PRO A 123
GLY A 124
LEU A 142
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.2A)
None
UNX  A1016 ( 2.9A)
SAH  A1001 (-4.2A)
 0.65A 4n49A-4mtlA:
9.4		 4n49A-4mtlA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 ALA A  95
GLY A 122
PRO A 123
GLY A 124
LEU A 205
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.2A)
None
UNX  A1016 ( 2.9A)
None
 1.03A 4n49A-4mtlA:
9.4		 4n49A-4mtlA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		4 / 6 PHE A 180
TYR A 211
LEU A 212
THR A 138
 None
UNX  A1009 ( 4.9A)
None
None
 1.28A 4paeA-4mtlA:
undetectable		 4paeA-4mtlA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 12 VAL A 137
GLU A 118
LEU A 133
ALA A 130
LEU A 220
 None
UNX  A1016 ( 2.6A)
None
None
None
 1.14A 5nd7B-4mtlA:
2.4		 5nd7B-4mtlA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4mtl PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21C
(Homo
sapiens) 		5 / 11 GLY A 120
GLY A 122
ASP A 141
LEU A 142
VAL A 145
 SAH  A1001 (-3.6A)
SAH  A1001 (-3.2A)
SAH  A1001 (-2.8A)
SAH  A1001 (-4.2A)
None
 0.45A 6i5zD-4mtlA:
6.0		 6i5zD-4mtlA:
19.80