SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 10 GLY A 506
SER A 505
LEU A 387
THR A 614
LEU A 500
 GLY  A 506 ( 0.0A)
SER  A 505 ( 0.0A)
LEU  A 387 ( 0.5A)
THR  A 614 ( 0.8A)
LEU  A 500 ( 0.6A)
 1.38A 1a8uA-4mtpA:
undetectable		 1a8uA-4mtpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.78A 1jnoA-4mtpA:
undetectable		 1jnoA-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.78A 1jnoB-4mtpA:
undetectable		 1jnoB-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.95A 1jo4A-4mtpA:
undetectable		 1jo4A-4mtpA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.95A 1jo4B-4mtpA:
undetectable		 1jo4B-4mtpA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.83A 1magA-4mtpA:
undetectable		 1magA-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.83A 1magB-4mtpA:
undetectable		 1magB-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.86A 1ng8A-4mtpA:
undetectable		 1ng8A-4mtpA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.86A 1ng8B-4mtpA:
undetectable		 1ng8B-4mtpA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.96A 1nrmA-4mtpA:
undetectable		 1nrmA-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.96A 1nrmB-4mtpA:
undetectable		 1nrmB-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.88A 1nruA-4mtpA:
undetectable		 1nruA-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.88A 1nruB-4mtpA:
undetectable		 1nruB-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 PHE A 401
VAL A 428
TRP A 434
 PHE  A 401 ( 1.3A)
VAL  A 428 ( 0.6A)
TRP  A 434 ( 0.5A)
 0.81A 2cc8A-4mtpA:
undetectable		 2cc8A-4mtpA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 PHE A 401
VAL A 428
TRP A 434
 PHE  A 401 ( 1.3A)
VAL  A 428 ( 0.6A)
TRP  A 434 ( 0.5A)
 0.83A 2ccbA-4mtpA:
undetectable		 2ccbA-4mtpA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 6 LEU A 491
LEU A 494
ILE A 571
ARG A 602
 LEU  A 491 ( 0.6A)
LEU  A 494 ( 0.6A)
ILE  A 571 ( 0.7A)
ARG  A 602 ( 0.6A)
 0.94A 2rlfA-4mtpA:
undetectable
2rlfB-4mtpA:
undetectable		 2rlfA-4mtpA:
4.94
2rlfB-4mtpA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		3 / 3 PHE A 401
VAL A 428
TRP A 434
 PHE  A 401 ( 1.3A)
VAL  A 428 ( 0.6A)
TRP  A 434 ( 0.5A)
 0.82A 2vx9A-4mtpA:
undetectable		 2vx9A-4mtpA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 8 THR A 574
TYR A 575
ARG A 568
ILE A 571
 THR  A 574 ( 0.8A)
TYR  A 575 ( 1.3A)
ARG  A 568 ( 0.6A)
ILE  A 571 ( 0.7A)
 1.07A 2xytE-4mtpA:
undetectable		 2xytE-4mtpA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 8 THR A 574
TYR A 575
ARG A 568
ILE A 571
 THR  A 574 ( 0.8A)
TYR  A 575 ( 1.3A)
ARG  A 568 ( 0.6A)
ILE  A 571 ( 0.7A)
 1.06A 2xytH-4mtpA:
undetectable		 2xytH-4mtpA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 11 ILE A 571
ASN A 377
LEU A 556
VAL A 608
LEU A 612
 ILE  A 571 ( 0.7A)
ASN  A 377 ( 0.6A)
LEU  A 556 ( 0.6A)
VAL  A 608 ( 0.6A)
LEU  A 612 ( 0.6A)
 1.09A 3a51A-4mtpA:
undetectable		 3a51A-4mtpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 9 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 ASP  A 541 ( 0.6A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
ASP  A 669 ( 0.6A)
 1.06A 3sfuA-4mtpA:
19.2		 3sfuA-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 9 ASP A 541
SER A 604
ASN A 613
GLY A 667
ASP A 668
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
 1.04A 3sfuA-4mtpA:
19.2		 3sfuA-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 9 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 ASP  A 541 ( 0.6A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
ASP  A 669 ( 0.6A)
 1.01A 3sfuB-4mtpA:
21.6		 3sfuB-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 11 ASP A 541
SER A 604
ASN A 613
GLY A 667
ASP A 668
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
 1.04A 3sfuC-4mtpA:
19.6		 3sfuC-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 11 ASP A 541
SER A 604
THR A 609
ASN A 613
GLY A 667
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
THR  A 609 ( 0.8A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
 1.11A 3sfuC-4mtpA:
19.6		 3sfuC-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 12 GLY A 667
ASP A 668
ILE A 665
ALA A 664
HIS A 803
 GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
ILE  A 665 ( 0.7A)
ALA  A 664 ( 0.0A)
HIS  A 803 ( 1.0A)
 1.28A 4wh5A-4mtpA:
undetectable		 4wh5A-4mtpA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 12 GLY A 507
VAL A 672
SER A 501
HIS A 386
LEU A 387
 GLY  A 507 ( 0.0A)
VAL  A 672 ( 0.6A)
SER  A 501 ( 0.0A)
HIS  A 386 ( 1.0A)
LEU  A 387 ( 0.5A)
 1.04A 5ubbA-4mtpA:
undetectable		 5ubbA-4mtpA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 5 LEU A 640
THR A 379
PRO A 368
ARG A 546
 LEU  A 640 ( 0.5A)
THR  A 379 ( 0.8A)
PRO  A 368 ( 1.1A)
ARG  A 546 ( 0.6A)
 1.38A 6ew0B-4mtpA:
undetectable		 6ew0B-4mtpA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 5 LEU A 640
THR A 379
PRO A 368
ARG A 546
 LEU  A 640 ( 0.5A)
THR  A 379 ( 0.8A)
PRO  A 368 ( 1.1A)
ARG  A 546 ( 0.6A)
 1.38A 6ew0D-4mtpA:
undetectable		 6ew0D-4mtpA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 5 LEU A 640
THR A 379
PRO A 368
ARG A 546
 LEU  A 640 ( 0.5A)
THR  A 379 ( 0.8A)
PRO  A 368 ( 1.1A)
ARG  A 546 ( 0.6A)
 1.38A 6ew0H-4mtpA:
undetectable		 6ew0H-4mtpA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		4 / 5 LEU A 640
THR A 379
PRO A 368
ARG A 546
 LEU  A 640 ( 0.5A)
THR  A 379 ( 0.8A)
PRO  A 368 ( 1.1A)
ARG  A 546 ( 0.6A)
 1.38A 6ew0I-4mtpA:
undetectable		 6ew0I-4mtpA:
7.95