SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mtt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PTH_A_SALA710_1 (PROSTAGLANDIN H2 SYNTHASE-1)	4mtt	LACTOYLGLUTATHIONE LYASE (Pseudomonas aeruginosa)	4 / 7	VAL A 44 LEU A 55 ALA A 16 LEU A 17	None	0.89A	1pthA-4mttA: undetectable	1pthA-4mttA: 12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AC9_C_DXCC1476_0 (MJ0495-LIKE PROTEIN)	4mtt	LACTOYLGLUTATHIONE LYASE (Pseudomonas aeruginosa)	4 / 5	ILE A 124 ALA A 82 HIS A 74 ARG A 98	GOL A 204 (-4.7A) None NI A 205 ( 3.3A) None	1.35A	4ac9B-4mttA: undetectable 4ac9C-4mttA: undetectable	4ac9B-4mttA: 13.63 4ac9C-4mttA: 13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AQL_A_TXCA1452_1 (GUANINE DEAMINASE)	4mtt	LACTOYLGLUTATHIONE LYASE (Pseudomonas aeruginosa)	5 / 12	LEU A 41 ARG A 9 GLU A 56 ALA A 16 HIS A 5	None None ZN A 203 (-2.8A) None ZN A 203 (-3.2A)	1.35A	4aqlA-4mttA: undetectable	4aqlA-4mttA: 14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_C_FUAC1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4mtt	LACTOYLGLUTATHIONE LYASE (Pseudomonas aeruginosa)	3 / 3	VAL A 44 HIS A 59 VAL A 10	None CL A 206 (-3.8A) None	0.70A	5jmnC-4mttA: undetectable	5jmnC-4mttA: 8.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PTH_A_SALA710_1","PROSTAGLANDIN H2 SYNTHASE-1","4mtt","LACTOYLGLUTATHIONE LYASE","Pseudomonas aeruginosa",4,"VAL A  44;LEU A  55;ALA A  16;LEU A  17","None","0.89A","1pthA-4mttA:undetectable","1pthA-4mttA:12.21"],["4AC9_C_DXCC1476_0","MJ0495-LIKE PROTEIN","4mtt","LACTOYLGLUTATHIONE LYASE","Pseudomonas aeruginosa",4,"ILE A 124;ALA A  82;HIS A  74;ARG A  98","GOL A 204 (-4.7A);None; NI A 205 ( 3.3A);None","1.35A","4ac9B-4mttA:undetectable;4ac9C-4mttA:undetectable","4ac9B-4mttA:13.63;4ac9C-4mttA:13.63"],["4AQL_A_TXCA1452_1","GUANINE DEAMINASE","4mtt","LACTOYLGLUTATHIONE LYASE","Pseudomonas aeruginosa",5,"LEU A  41;ARG A   9;GLU A  56;ALA A  16;HIS A   5","None;None; ZN A 203 (-2.8A);None; ZN A 203 (-3.2A)","1.35A","4aqlA-4mttA:undetectable","4aqlA-4mttA:14.77"],["5JMN_C_FUAC1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","4mtt","LACTOYLGLUTATHIONE LYASE","Pseudomonas aeruginosa",3,"VAL A  44;HIS A  59;VAL A  10","None; CL A 206 (-3.8A);None","0.70A","5jmnC-4mttA:undetectable","5jmnC-4mttA:8.47"]]