SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		5 / 12 ILE A  42
LEU A  37
LYS A  39
ILE A 290
LEU A 264
 None
 1.23A 1ddrB-4mu6A:
undetectable		 1ddrB-4mu6A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		4 / 5 LEU A 267
ILE A  36
LEU A  37
SER A  38
 None
 0.99A 2byoA-4mu6A:
undetectable		 2byoA-4mu6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		4 / 4 ASN A 106
SER A 175
LEU A 176
THR A 102
 None
 1.25A 4an2A-4mu6A:
undetectable		 4an2A-4mu6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		5 / 12 ILE A  42
LEU A  37
LYS A  39
ILE A 290
LEU A 264
 None
 1.11A 4ej1B-4mu6A:
undetectable		 4ej1B-4mu6A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		5 / 12 ILE A  42
LEU A  37
LYS A  39
ILE A 290
LEU A 264
 None
 1.14A 4qi9A-4mu6A:
undetectable		 4qi9A-4mu6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		5 / 12 ILE A  42
LEU A  37
LYS A  39
ILE A 290
LEU A 264
 None
 1.13A 4qi9B-4mu6A:
undetectable		 4qi9B-4mu6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		4 / 6 TYR A 270
GLY A  31
SER A  28
LEU A  27
 None
 1.28A 5bphD-4mu6A:
undetectable		 5bphD-4mu6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		5 / 12 ILE A  42
LEU A  37
LYS A  39
ILE A 290
LEU A 264
 None
 1.16A 5e8qB-4mu6A:
undetectable		 5e8qB-4mu6A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4mu6 KINECTIN 1 (KINESIN
RECEPTOR)
(Legionella
pneumophila) 		4 / 7 GLN A  76
GLY A 227
ILE A 232
GLN A 238
 None
 0.96A 5vlmC-4mu6A:
undetectable		 5vlmC-4mu6A:
21.31