SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mud'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 11 ASP A 113
GLU A 142
GLU A  29
SER A  95
GLU A  59
 None
 1.37A 1rnrA-4mudA:
15.6		 1rnrA-4mudA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 11 ASP A 113
GLU A 142
HIS A 145
GLU A  29
GLU A  59
 None
 0.84A 1rnrA-4mudA:
15.6		 1rnrA-4mudA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ASP A 113
GLU A 142
HIS A 145
GLU A  29
GLU A  59
 None
 0.74A 1rnrB-4mudA:
15.2		 1rnrB-4mudA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 SER A 182
GLU A  23
ASP A  77
 None
 0.75A 2zulA-4mudA:
undetectable		 2zulA-4mudA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 LEU A 153
SER A 149
THR A 109
ALA A 165
 None
 0.84A 3ax9B-4mudA:
undetectable		 3ax9B-4mudA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 SER A 182
GLU A  23
ASP A  77
 None
 0.75A 3dmhA-4mudA:
undetectable		 3dmhA-4mudA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 9 PHE A  28
VAL A  94
SER A  95
ALA A 173
ALA A 107
 None
 1.13A 3mdtA-4mudA:
undetectable		 3mdtA-4mudA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 SER A 149
THR A 109
LEU A 111
ALA A 165
 None
 0.85A 3ns1L-4mudA:
undetectable		 3ns1L-4mudA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 HIS A 145
LEU A  30
LEU A  66
ASP A  27
 None
 1.19A 4aqlA-4mudA:
undetectable		 4aqlA-4mudA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ALA A  31
VAL A  94
VAL A 112
ASP A 113
GLY A 116
 None
 1.01A 5x24A-4mudA:
0.8		 5x24A-4mudA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 GLY A  63
TRP A  64
GLU A 141
PHE A  28
LEU A 120
 None
 1.47A 6a5kA-4mudA:
undetectable		 6a5kA-4mudA:
18.41