SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4muz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		4 / 4 ARG A  92
ALA A  91
ALA A 120
GLU A 122
 None
 1.08A 1e7bA-4muzA:
undetectable		 1e7bA-4muzA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		4 / 5 ARG A  92
ALA A  91
ALA A 120
GLU A 122
 None
 1.15A 1e7cA-4muzA:
undetectable		 1e7cA-4muzA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  80
GLY A 106
SER A 110
GLU A 115
ALA A 153
 None
 1.04A 1sg9C-4muzA:
undetectable		 1sg9C-4muzA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 182
GLY A 203
ASP A 202
ALA A 201
ALA A 197
 None
 1.11A 2br4B-4muzA:
undetectable		 2br4B-4muzA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 100
ILE A  75
ILE A  25
GLU A 182
 None
 0.70A 2j9dJ-4muzA:
undetectable
2j9dK-4muzA:
undetectable
2j9dL-4muzA:
undetectable		 2j9dJ-4muzA:
22.27
2j9dK-4muzA:
22.27
2j9dL-4muzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 131
ILE A 162
TYR A 128
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.18A 2y7kC-4muzA:
undetectable		 2y7kC-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 131
ILE A 162
LEU A 171
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.14A 2y7kD-4muzA:
undetectable		 2y7kD-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 131
ILE A 162
TYR A 128
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.08A 2y7kD-4muzA:
undetectable		 2y7kD-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		4 / 8 ILE A  80
ALA A  91
PHE A  95
ALA A  99
 None
 0.90A 3hrdA-4muzA:
undetectable
3hrdB-4muzA:
undetectable		 3hrdA-4muzA:
21.08
3hrdB-4muzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A 109
ALA A 129
GLY A 106
VAL A 116
CYH A 158
 None
 1.32A 4c5lD-4muzA:
2.8		 4c5lD-4muzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A 109
ALA A 129
GLY A 106
VAL A 116
CYH A 158
 None
 1.28A 4c5nD-4muzA:
2.9		 4c5nD-4muzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 8 LEU A  26
ALA A  40
MET A  37
ILE A  39
LEU A  56
 None
 1.22A 4wboB-4muzA:
undetectable		 4wboB-4muzA:
19.96