SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 4 ARG A 270
ALA A 316
ALA A  77
GLU A  96
 None
 1.21A 1e7bA-4mv3A:
undetectable		 1e7bA-4mv3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		5 / 12 ALA A 386
LEU A 388
LEU A  15
LEU A 357
LEU A 406
 None
 1.13A 1errB-4mv3A:
undetectable		 1errB-4mv3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		5 / 11 GLU A 336
PRO A 298
HIS A 333
ALA A 334
GLY A 332
 None
 1.33A 1mjqI-4mv3A:
undetectable
1mjqJ-4mv3A:
undetectable		 1mjqI-4mv3A:
13.07
1mjqJ-4mv3A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.83A 1xwfA-4mv3A:
undetectable		 1xwfA-4mv3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.83A 1xwfB-4mv3A:
undetectable		 1xwfB-4mv3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.84A 1xwfC-4mv3A:
undetectable		 1xwfC-4mv3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 THR A 304
GLU A 227
HIS A 333
 None
 0.85A 1xwfD-4mv3A:
undetectable		 1xwfD-4mv3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 7 SER A  33
HIS A  41
TYR A  60
TYR A 381
 None
 1.42A 2vmyA-4mv3A:
undetectable
2vmyB-4mv3A:
2.9		 2vmyA-4mv3A:
21.17
2vmyB-4mv3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 8 LYS A 238
ASN A 290
ARG A 292
GLU A 296
 BCT  A 503 ( 3.8A)
ACP  A 501 (-3.9A)
BCT  A 503 (-2.7A)
BCT  A 503 (-3.4A)
 0.96A 2ys6A-4mv3A:
28.4		 2ys6A-4mv3A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		5 / 10 TYR A  60
ILE A  63
ASN A  62
ALA A  65
VAL A  95
 None
 1.25A 3ay0A-4mv3A:
2.4		 3ay0A-4mv3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		5 / 11 PRO A 244
LEU A 225
VAL A 306
THR A 300
ARG A 401
 None
 1.37A 3n23C-4mv3A:
1.8		 3n23C-4mv3A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 HIS A 358
HIS A 356
ILE A 410
 None
 0.81A 3u52A-4mv3A:
undetectable
3u52C-4mv3A:
undetectable		 3u52A-4mv3A:
19.52
3u52C-4mv3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 5 LYS A 345
ILE A 418
VAL A 239
LEU A 440
 None
 1.15A 3wzdA-4mv3A:
undetectable		 3wzdA-4mv3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		5 / 12 ARG A 338
GLU A 241
LEU A 308
GLU A 211
ASN A 290
 BCT  A 503 (-3.5A)
None
None
None
ACP  A 501 (-3.9A)
 1.47A 4cpzB-4mv3A:
undetectable		 4cpzB-4mv3A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		5 / 12 ARG A 338
GLU A 241
LEU A 308
ALA A 272
GLU A 211
 BCT  A 503 (-3.5A)
None
None
None
None
 1.30A 4cpzD-4mv3A:
undetectable		 4cpzD-4mv3A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 5 ARG A  16
ILE A  17
HIS A  79
GLY A  81
 None
 1.21A 4e7cC-4mv3A:
undetectable		 4e7cC-4mv3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 5 HIS A  32
ALA A  30
HIS A  41
TYR A  60
 None
 1.18A 4gboB-4mv3A:
undetectable		 4gboB-4mv3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 6 VAL A  31
VAL A   6
ILE A  78
LEU A  85
 None
 0.95A 4l1wB-4mv3A:
undetectable		 4l1wB-4mv3A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		6 / 7 LYS A 238
ASN A 290
ARG A 292
VAL A 295
GLU A 296
ARG A 338
 BCT  A 503 ( 3.8A)
ACP  A 501 (-3.9A)
BCT  A 503 (-2.7A)
BCT  A 503 (-3.8A)
BCT  A 503 (-3.4A)
BCT  A 503 (-3.5A)
 0.35A 4mv7A-4mv3A:
65.5		 4mv7A-4mv3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		6 / 7 LYS A 238
ASN A 290
GLN A 294
VAL A 295
GLU A 296
ARG A 338
 BCT  A 503 ( 3.8A)
ACP  A 501 (-3.9A)
BCT  A 503 (-4.3A)
BCT  A 503 (-3.8A)
BCT  A 503 (-3.4A)
BCT  A 503 (-3.5A)
 0.69A 4mv7A-4mv3A:
65.5		 4mv7A-4mv3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 6 ILE A 158
HIS A 236
ILE A 287
VAL A 131
 None
ACP  A 501 ( 3.9A)
ACP  A 501 ( 4.3A)
ACP  A 501 ( 4.5A)
 1.01A 4zj8A-4mv3A:
undetectable		 4zj8A-4mv3A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 ASP A  36
SER A  59
TYR A  60
 None
 0.89A 5glmA-4mv3A:
undetectable		 5glmA-4mv3A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		5 / 12 ILE A 293
THR A 304
ILE A 303
ALA A 243
GLU A 241
 None
 0.95A 5vceA-4mv3A:
undetectable		 5vceA-4mv3A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 GLU A 311
LEU A 308
ARG A  16
 None
 0.68A 6d8fA-4mv3A:
undetectable		 6d8fA-4mv3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		3 / 3 TYR A  60
ALA A  14
LEU A  39
 None
 0.74A 6d9kF-4mv3A:
undetectable		 6d9kF-4mv3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4mv3 BIOTIN CARBOXYLASE
(Haemophilus
influenzae) 		4 / 6 ASP A 368
GLU A 301
ASP A 307
GLU A  23
 None
 1.41A 6mn5A-4mv3A:
undetectable		 6mn5A-4mv3A:
10.93