SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mvc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 PHE A 124
THR A 125
ASP A 115
HIS A 119
 None
 1.00A 1ei6C-4mvcA:
undetectable		 1ei6C-4mvcA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 PHE A 124
THR A 125
ASP A 115
HIS A 119
 None
 0.99A 1ei6D-4mvcA:
undetectable		 1ei6D-4mvcA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 5 LEU A 153
VAL A 181
TYR A 182
THR A 152
 None
None
CDC  A 401 (-4.6A)
None
 1.12A 1nw3A-4mvcA:
undetectable		 1nw3A-4mvcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.12A 2xadA-4mvcA:
3.6		 2xadA-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.07A 2xadB-4mvcA:
3.8		 2xadB-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.08A 2xadC-4mvcA:
3.7		 2xadC-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.05A 2xadD-4mvcA:
3.7		 2xadD-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 7 PHE A 124
THR A 125
ASP A 115
HIS A 119
 None
 0.94A 3t01A-4mvcA:
undetectable		 3t01A-4mvcA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		5 / 10 GLY A 111
ALA A  45
VAL A 145
GLU A 144
VAL A 112
 None
 1.30A 4da7A-4mvcA:
undetectable		 4da7A-4mvcA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 6 PHE A  85
PHE A  88
ALA A  95
LEU A 108
 CDC  A 401 (-4.6A)
None
CDC  A 401 (-3.5A)
None
 1.01A 4ejgD-4mvcA:
undetectable		 4ejgD-4mvcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		3 / 3 ARG A 132
THR A 118
ASP A 115
 None
 0.96A 5g5gA-4mvcA:
undetectable
5g5gB-4mvcA:
undetectable		 5g5gA-4mvcA:
21.12
5g5gB-4mvcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		3 / 3 ALA A 217
ASN A 220
LEU A 221
 None
 0.39A 5i1oC-4mvcA:
undetectable		 5i1oC-4mvcA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		3 / 3 ALA A 217
ASN A 220
LEU A 221
 None
 0.32A 5i1pA-4mvcA:
undetectable		 5i1pA-4mvcA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 7 GLY A  83
PHE A  85
HIS A  92
SER A 201
 CDC  A 401 (-3.0A)
CDC  A 401 (-4.6A)
CDC  A 401 ( 4.5A)
None
 0.72A 6jnhA-4mvcA:
9.8		 6jnhA-4mvcA:
18.94