SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		3 / 3 GLN A  96
HIS A 366
PRO A 450
 None
 0.90A 1d8cA-4mvfA:
undetectable		 1d8cA-4mvfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 11 PHE A 454
ILE A 462
LEU A  60
VAL A 492
MET A 508
 None
 1.03A 1dtlA-4mvfA:
9.2		 1dtlA-4mvfA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 11 PHE A 454
ILE A 462
LEU A 467
VAL A 492
MET A 508
 None
 0.74A 1dtlA-4mvfA:
9.2		 1dtlA-4mvfA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 12 PHE A 349
PHE A 454
LEU A 467
LEU A 488
MET A 509
 None
 1.13A 1dtlA-4mvfA:
9.2		 1dtlA-4mvfA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.93A 1iepA-4mvfA:
19.3		 1iepA-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-3.4A)
 0.77A 1iepB-4mvfA:
19.2		 1iepB-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 9 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.7A)
 0.49A 1muoA-4mvfA:
6.0		 1muoA-4mvfA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 5 ILE A 303
TRP A 292
LEU A 307
PRO A 267
 None
 1.23A 1s8fA-4mvfA:
undetectable
1s8fB-4mvfA:
undetectable		 1s8fA-4mvfA:
17.34
1s8fB-4mvfA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 ALA A  99
LYS A 101
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.2A)
None
None
 0.76A 1uwhB-4mvfA:
20.9		 1uwhB-4mvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 VAL A  86
ALA A  99
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
None
None
 0.76A 1uwjA-4mvfA:
20.6		 1uwjA-4mvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 VAL A  86
ALA A  99
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
None
None
 0.75A 1uwjB-4mvfA:
20.1		 1uwjB-4mvfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 9 LEU A  78
VAL A  86
LEU A 132
LEU A 144
LEU A 148
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
None
None
STU  A 601 (-4.3A)
 0.50A 1xkkA-4mvfA:
19.0		 1xkkA-4mvfA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 4 GLY A 215
SER A 217
ILE A 211
HIS A 190
 None
 1.40A 1yajJ-4mvfA:
undetectable		 1yajJ-4mvfA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		9 / 12 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LYS A 101
GLU A 117
MET A 121
LEU A 144
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
None
STU  A 601 (-4.3A)
 0.85A 2ityA-4mvfA:
20.8		 2ityA-4mvfA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 10 VAL A  86
ALA A  99
ILE A 212
LEU A 148
GLY A 151
LEU A 199
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 1.02A 2y7jD-4mvfA:
25.9		 2y7jD-4mvfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 11 LEU A  78
VAL A  86
ALA A  99
CYH A 149
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.51A 3g0eA-4mvfA:
18.0		 3g0eA-4mvfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 11 LEU A  78
VAL A  86
ALA A  99
CYH A 149
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.61A 3g0fA-4mvfA:
19.0		 3g0fA-4mvfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 10 LEU A  78
VAL A  86
ALA A  99
CYH A 149
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.53A 3g0fB-4mvfA:
18.9		 3g0fB-4mvfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
VAL A 130
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
None
 0.61A 3gvuA-4mvfA:
19.6		 3gvuA-4mvfA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 8 GLU A 491
ASN A 353
MET A 508
LYS A 356
 None
 1.22A 3kp6A-4mvfA:
undetectable
3kp6B-4mvfA:
undetectable		 3kp6A-4mvfA:
15.63
3kp6B-4mvfA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 8 ALA A  99
LYS A 101
GLU A 117
LEU A 144
LEU A 148
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.3A)
 0.59A 3lfaA-4mvfA:
19.2		 3lfaA-4mvfA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.7A)
 0.93A 3ms9A-4mvfA:
18.9		 3ms9A-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.89A 3ms9B-4mvfA:
19.0		 3ms9B-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.7A)
 0.95A 3mssA-4mvfA:
19.0		 3mssA-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.7A)
 0.94A 3mssC-4mvfA:
19.0		 3mssC-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
ALA A  99
GLU A 117
MET A 121
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.90A 3mssD-4mvfA:
19.0		 3mssD-4mvfA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
GLU A 117
MET A 121
VAL A 130
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
None
 0.70A 3pyyB-4mvfA:
19.4		 3pyyB-4mvfA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 LEU A  78
VAL A  86
ALA A  99
LEU A 144
MET A 146
LEU A 148
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
 0.87A 3ug2A-4mvfA:
20.4		 3ug2A-4mvfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
VAL A  86
ALA A  99
LYS A 101
LEU A 144
LEU A 148
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 1.06A 3ug2A-4mvfA:
20.4		 3ug2A-4mvfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 GLY A  81
GLY A  84
VAL A  86
ALA A  99
LYS A 101
VAL A 130
 STU  A 601 (-3.9A)
None
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
 0.83A 3v5wA-4mvfA:
22.6		 3v5wA-4mvfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
GLY A  79
ALA A  99
CYH A 149
GLY A 151
PHE A 214
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
None
 1.05A 3wzdA-4mvfA:
14.4		 3wzdA-4mvfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
CYH A 149
GLY A 151
PHE A 214
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
None
 0.94A 3wzdA-4mvfA:
14.4		 3wzdA-4mvfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 9 ILE A 120
MET A 121
LEU A 124
ILE A 129
ILE A 211
 None
 0.78A 3zosA-4mvfA:
19.1		 3zosA-4mvfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 9 ILE A 120
MET A 121
LEU A 124
ILE A 129
ILE A 211
 None
 0.79A 3zosB-4mvfA:
19.5		 3zosB-4mvfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LEU A 144
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.82A 4i22A-4mvfA:
18.8		 4i22A-4mvfA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LEU A 144
MET A 146
GLY A 151
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 0.87A 4i22A-4mvfA:
18.8		 4i22A-4mvfA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 VAL A  86
ALA A  99
ASP A 192
ASN A 197
LEU A 199
ILE A 212
ASP A 213
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
 0.60A 4i41A-4mvfA:
23.6		 4i41A-4mvfA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 11 ALA A  99
LYS A 101
GLU A 196
LEU A 199
ILE A 212
ASP A 213
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
 1.12A 4iaaA-4mvfA:
23.4		 4iaaA-4mvfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 11 VAL A  86
ALA A  99
LYS A 101
LEU A 199
ILE A 212
ASP A 213
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
 0.76A 4iaaA-4mvfA:
23.4		 4iaaA-4mvfA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 GLY A  79
VAL A  86
ALA A  99
LEU A 132
LEU A 144
LEU A 199
ILE A 212
 STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.58A 4ifgA-4mvfA:
24.2		 4ifgA-4mvfA:
38.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
GLY A  81
VAL A  86
ALA A  99
LEU A 148
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.9A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.96A 4mkcA-4mvfA:
21.0		 4mkcA-4mvfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 6 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.7A)
 0.46A 4o0wA-4mvfA:
25.6		 4o0wA-4mvfA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 7 ALA A  99
CYH A 149
ASN A 197
LEU A 199
ASP A 213
 STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
None
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 1.04A 4ogrE-4mvfA:
21.9		 4ogrE-4mvfA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
GLY A  79
GLY A  81
GLY A  84
VAL A  86
ALA A  99
LYS A 101
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.7A)
 0.58A 4otiA-4mvfA:
22.1		 4otiA-4mvfA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 12 ALA A  99
GLU A 117
MET A 121
LEU A 183
ARG A 191
 STU  A 601 (-3.3A)
None
None
None
None
 0.83A 4qrcA-4mvfA:
15.2		 4qrcA-4mvfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 VAL A  86
ALA A  99
LYS A 101
GLU A 117
MET A 121
CYH A 149
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.2A)
 0.76A 4r7iA-4mvfA:
18.5		 4r7iA-4mvfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 6 LEU A  78
VAL A  86
ILE A 129
ILE A 211
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
None
None
 0.63A 4tyjA-4mvfA:
19.6		 4tyjA-4mvfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 10 LEU A  78
VAL A  86
LEU A 124
ILE A 129
VAL A 130
ILE A 211
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
None
None
None
None
 0.69A 4u0iA-4mvfA:
19.0		 4u0iA-4mvfA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 12 ALA A  99
GLU A 117
MET A 121
LEU A 183
HIS A 190
 STU  A 601 (-3.3A)
None
None
None
None
 0.82A 4v01B-4mvfA:
18.9		 4v01B-4mvfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 8 LEU A  78
ALA A  99
MET A 146
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.7A)
 0.57A 4wboB-4mvfA:
20.6		 4wboB-4mvfA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 6 LEU A  78
ALA A  99
MET A 146
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.7A)
 0.59A 4wboC-4mvfA:
20.7		 4wboC-4mvfA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 LEU A  78
ALA A  99
LYS A 101
GLU A 117
MET A 121
LEU A 144
LEU A 148
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
None
STU  A 601 (-4.3A)
 0.69A 4wkqA-4mvfA:
15.9		 4wkqA-4mvfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 VAL A  86
ALA A  99
LYS A 101
CYH A 149
ASP A 213
PHE A 214
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.2A)
STU  A 601 (-4.3A)
None
 1.01A 4xv2A-4mvfA:
21.3		 4xv2A-4mvfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 12 ALA A  99
LYS A 101
CYH A 149
ASP A 213
PHE A 214
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.2A)
STU  A 601 (-4.3A)
None
 0.86A 4xv2B-4mvfA:
21.7		 4xv2B-4mvfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 LEU A  78
GLY A  79
ALA A  99
CYH A 149
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.96A 5ajqA-4mvfA:
22.2		 5ajqA-4mvfA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 5 GLU A 371
THR A 440
THR A 361
HIS A 427
 None
 1.30A 5axaC-4mvfA:
undetectable		 5axaC-4mvfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 12 VAL A  86
ALA A  99
LYS A 101
CYH A 149
PHE A 214
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.2A)
None
 0.84A 5cswA-4mvfA:
20.9		 5cswA-4mvfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 12 VAL A  86
ALA A  99
LYS A 101
CYH A 149
PHE A 214
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.2A)
None
 0.84A 5cswB-4mvfA:
21.2		 5cswB-4mvfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
LEU A 148
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.65A 5h2uA-4mvfA:
14.6		 5h2uA-4mvfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
LEU A 148
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.56A 5h2uD-4mvfA:
19.3		 5h2uD-4mvfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 ALA A  99
LYS A 101
GLU A 117
CYH A 149
LEU A 183
HIS A 190
 STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.2A)
None
None
 0.78A 5hi2A-4mvfA:
21.7		 5hi2A-4mvfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 6 HIS A 184
LEU A 183
CYH A 249
LEU A 193
 None
 1.24A 5hrqD-4mvfA:
undetectable
5hrqG-4mvfA:
undetectable
5hrqH-4mvfA:
undetectable		 5hrqD-4mvfA:
4.61
5hrqG-4mvfA:
5.15
5hrqH-4mvfA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 6 HIS A 184
LEU A 183
CYH A 249
LEU A 193
 None
 1.23A 5hrqB-4mvfA:
undetectable
5hrqI-4mvfA:
undetectable
5hrqJ-4mvfA:
undetectable		 5hrqB-4mvfA:
4.61
5hrqI-4mvfA:
5.15
5hrqJ-4mvfA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 10 GLY A  79
VAL A  86
ALA A  99
MET A 146
LEU A 148
 STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
 0.55A 5lw1E-4mvfA:
19.4		 5lw1E-4mvfA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 9 GLY A  79
VAL A  86
ALA A  99
MET A 146
LEU A 148
 STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
 0.53A 5lw1H-4mvfA:
19.8		 5lw1H-4mvfA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 8 ALA A  99
GLU A 117
CYH A 149
LEU A 199
 STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
STU  A 601 (-4.7A)
 0.72A 5owrA-4mvfA:
23.0		 5owrA-4mvfA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 5 LEU A  78
VAL A  86
MET A 146
CYH A 149
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.2A)
 0.45A 5te0A-4mvfA:
22.9		 5te0A-4mvfA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 10 LEU A 467
GLU A 491
VAL A 492
ILE A 500
MET A 509
 None
 0.70A 5v02B-4mvfA:
undetectable
5v02R-4mvfA:
5.3		 5v02B-4mvfA:
12.65
5v02R-4mvfA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 GLU A  76
GLY A  79
ALA A  99
GLU A 117
GLY A 151
ASP A 213
 None
STU  A 601 (-3.6A)
STU  A 601 (-3.3A)
None
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 1.08A 5vc3A-4mvfA:
22.8		 5vc3A-4mvfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 GLY A  79
ALA A  99
GLU A 117
CYH A 149
GLY A 151
ASP A 213
 STU  A 601 (-3.6A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 0.85A 5vc3A-4mvfA:
22.8		 5vc3A-4mvfA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
ALA A  99
LYS A 101
GLU A 117
LEU A 144
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-3.4A)
 1.10A 5vcvA-4mvfA:
22.5		 5vcvA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
ALA A  99
LYS A 101
GLU A 117
VAL A 130
LEU A 144
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
None
 0.80A 5vcvA-4mvfA:
22.5		 5vcvA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 144
CYH A 149
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.2A)
 0.66A 5vcyA-4mvfA:
22.2		 5vcyA-4mvfA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 9 LEU A  78
ALA A  99
MET A 146
CYH A 149
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
 0.67A 5w5vA-4mvfA:
3.9		 5w5vA-4mvfA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 9 LEU A  78
ALA A  99
VAL A 130
MET A 146
CYH A 149
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.3A)
STU  A 601 (-4.2A)
 0.68A 5w5vA-4mvfA:
3.9		 5w5vA-4mvfA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		9 / 12 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.80A 5y7zA-4mvfA:
22.9		 5y7zA-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		9 / 12 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.80A 5y7zA-4mvfA:
22.9		 5y7zA-4mvfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
ALA A  99
GLU A 117
LEU A 144
LEU A 148
CYH A 149
GLY A 151
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 0.88A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
ALA A  99
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.85A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
ALA A  99
LYS A 101
GLU A 117
LEU A 144
LEU A 148
GLY A 151
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 0.89A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		8 / 12 LEU A  78
ALA A  99
LYS A 101
GLU A 117
LEU A 148
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.80A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		10 / 12 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.88A 5y80A-4mvfA:
23.0		 5y80A-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 8 VAL A  86
LYS A 101
ILE A 212
ASP A 213
 STU  A 601 (-4.8A)
STU  A 601 (-3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
 0.51A 5y9mX-4mvfA:
21.2		 5y9mX-4mvfA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		4 / 7 VAL A  86
LYS A 101
ILE A 212
ASP A 213
 STU  A 601 (-4.8A)
STU  A 601 (-3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
 0.63A 5yf9B-4mvfA:
21.0		 5yf9B-4mvfA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		6 / 12 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-3.4A)
 0.73A 5zv2B-4mvfA:
19.1		 5zv2B-4mvfA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		7 / 12 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
MET A 121
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.7A)
 1.04A 6hd6B-4mvfA:
18.6		 6hd6B-4mvfA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2
(Plasmodium
falciparum) 		5 / 10 ASP A  91
TYR A 136
HIS A  64
ASP A 457
GLU A 466
 None
None
None
CA  A 603 (-2.9A)
CA  A 603 (-2.2A)
 1.15A 6mb9D-4mvfA:
undetectable		 6mb9D-4mvfA:
9.73