SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		4 / 4 ILE A 242
LEU A 147
VAL A 260
ILE A 258
 UNX  A 508 ( 4.6A)
None
None
None
 0.68A 1fm6D-4mvtA:
undetectable		 1fm6D-4mvtA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		5 / 12 LEU A 353
ASP A 350
THR A 335
LEU A 286
GLY A 283
 None
None
None
None
UNX  A 512 ( 3.7A)
 1.42A 1v8bD-4mvtA:
undetectable		 1v8bD-4mvtA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		4 / 4 LEU A 334
PRO A 297
ILE A 387
LEU A 388
 None
 1.16A 1ya4C-4mvtA:
undetectable		 1ya4C-4mvtA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		5 / 12 PHE A 134
PRO A 362
ILE A 244
ASN A 243
PHE A 194
 None
 1.32A 2zznB-4mvtA:
undetectable		 2zznB-4mvtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		5 / 10 LEU A 272
PHE A 162
VAL A 274
ASN A 256
ALA A 248
 None
 1.48A 3nuvB-4mvtA:
undetectable		 3nuvB-4mvtA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		4 / 4 VAL A 260
PHE A 160
PHE A 162
VAL A 190
 None
 1.44A 3rv5C-4mvtA:
undetectable
3rv5D-4mvtA:
undetectable		 3rv5C-4mvtA:
12.68
3rv5D-4mvtA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		4 / 6 LEU A 192
PHE A 194
LEU A 272
PHE A 160
 None
 1.07A 3wg7C-4mvtA:
undetectable
3wg7J-4mvtA:
undetectable		 3wg7C-4mvtA:
20.45
3wg7J-4mvtA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		4 / 8 ARG A 333
LEU A 378
ILE A 380
PHE A 349
 None
 0.80A 4v04A-4mvtA:
undetectable		 4v04A-4mvtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4mvt E3 SUMO-PROTEIN
LIGASE PIAS3
(Homo
sapiens) 		4 / 8 GLY A 139
GLU A 136
ILE A 188
GLN A 170
 UNX  A 506 ( 3.9A)
None
None
None
 0.87A 5vlmD-4mvtA:
undetectable		 5vlmD-4mvtA:
19.51