SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ALA A  33
VAL A  93
TRP A  36
 None
 0.93A 1gmkA-4mwfA:
undetectable
1gmkB-4mwfA:
undetectable		 1gmkA-4mwfA:
5.14
1gmkB-4mwfA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4mwf ENVELOPE
GLYCOPROTEIN E2
(Hepacivirus
C) 		3 / 3 ASN C 532
ALA C 499
ASN C 428
 NAG  C 711 (-1.7A)
None
None
 0.81A 1n4fA-4mwfC:
undetectable		 1n4fA-4mwfC:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG A  94
ILE A  69
TRP A  36
 None
 1.14A 1qomA-4mwfA:
undetectable		 1qomA-4mwfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4mwf ENVELOPE
GLYCOPROTEIN E2
FAB AR3C HEAVY CHAIN
(Hepacivirus
C;
Homo
sapiens) 		3 / 3 SER A 161
GLY A 162
ARG C 606
 None
 0.56A 1t9wA-4mwfA:
undetectable		 1t9wA-4mwfA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU A   4
GLY A  78
ILE A  48
GLY A  49
GLY A  50
 None
 0.89A 2avvD-4mwfA:
undetectable		 2avvD-4mwfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG A  94
ILE A  69
TRP A  36
 None
 1.13A 3e7iB-4mwfA:
undetectable		 3e7iB-4mwfA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG A  94
ILE A  69
TRP A  36
 None
 1.15A 3nw2B-4mwfA:
undetectable		 3nw2B-4mwfA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		4 / 8 SER A  95
TYR A  32
TRP A  47
GLY A  50
 None
 0.75A 5albL-4mwfA:
14.3		 5albL-4mwfA:
30.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		4 / 8 SER A  95
TYR A  32
TRP A  47
GLY A  50
 None
 0.81A 5alcL-4mwfA:
14.5		 5alcL-4mwfA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_A_IPHA101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		4 / 5 CYH A  92
CYH A  22
LEU A  34
HIS A  79
 None
 1.33A 5hrqA-4mwfA:
undetectable
5hrqB-4mwfA:
undetectable
5hrqF-4mwfA:
undetectable		 5hrqA-4mwfA:
6.60
5hrqB-4mwfA:
10.18
5hrqF-4mwfA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		4 / 5 CYH A  92
CYH A  22
LEU A  34
HIS A  79
 None
 1.34A 5hrqC-4mwfA:
undetectable
5hrqD-4mwfA:
undetectable
5hrqL-4mwfA:
undetectable		 5hrqC-4mwfA:
6.60
5hrqD-4mwfA:
10.18
5hrqL-4mwfA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		4 / 6 HIS A  79
CYH A  92
CYH A  22
LEU A  34
 None
 1.21A 5hrqD-4mwfA:
undetectable
5hrqG-4mwfA:
undetectable
5hrqH-4mwfA:
undetectable		 5hrqD-4mwfA:
10.18
5hrqG-4mwfA:
6.60
5hrqH-4mwfA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		5 / 6 VAL A  20
HIS A  79
CYH A  92
CYH A  22
LEU A  34
 None
 1.40A 5hrqB-4mwfA:
undetectable
5hrqI-4mwfA:
undetectable
5hrqJ-4mwfA:
undetectable		 5hrqB-4mwfA:
10.18
5hrqI-4mwfA:
6.60
5hrqJ-4mwfA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		5 / 6 VAL A  20
HIS A  79
CYH A  92
CYH A  22
LEU A  34
 None
 1.40A 5hrqH-4mwfA:
undetectable
5hrqK-4mwfA:
undetectable
5hrqL-4mwfA:
undetectable		 5hrqH-4mwfA:
10.18
5hrqK-4mwfA:
6.60
5hrqL-4mwfA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4mwf ENVELOPE
GLYCOPROTEIN E2
(Hepacivirus
C) 		4 / 8 TYR C 613
CYH C 429
TRP C 616
LEU C 438
 None
 1.02A 5kxiA-4mwfC:
undetectable
5kxiB-4mwfC:
undetectable		 5kxiA-4mwfC:
21.35
5kxiB-4mwfC:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4mwf ENVELOPE
GLYCOPROTEIN E2
(Hepacivirus
C) 		4 / 8 TYR C 613
CYH C 429
TRP C 616
LEU C 438
 None
 1.02A 5kxiD-4mwfC:
undetectable
5kxiE-4mwfC:
undetectable		 5kxiD-4mwfC:
21.35
5kxiE-4mwfC:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 4mwf ENVELOPE
GLYCOPROTEIN E2
(Hepacivirus
C) 		4 / 4 THR C 561
VAL C 563
PRO C 601
THR C 553
 None
 1.38A 5mthA-4mwfC:
undetectable
5mthH-4mwfC:
undetectable		 5mthA-4mwfC:
20.34
5mthH-4mwfC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL A 207
THR A 205
VAL A 211
GLY A 118
VAL A 152
 None
 1.04A 6drzA-4mwfA:
undetectable		 6drzA-4mwfA:
19.32