SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		5 / 12 LEU A  39
PHE A  18
LEU A  35
LEU A 178
ILE A 129
 None
 1.00A 2bxqA-4mwgA:
undetectable		 2bxqA-4mwgA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		5 / 9 LEU A  29
LEU A  46
ALA A  60
GLU A  51
ALA A  50
 None
 1.04A 3mdvA-4mwgA:
undetectable		 3mdvA-4mwgA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		5 / 10 LEU A  84
ALA A 119
GLY A 122
ILE A 126
PHE A  45
 None
 1.19A 3qpsA-4mwgA:
undetectable		 3qpsA-4mwgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		3 / 3 ARG A  69
MET A  88
ARG A  17
 None
 1.30A 3uvvA-4mwgA:
undetectable		 3uvvA-4mwgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		5 / 10 PRO A 114
ALA A 121
GLY A 128
THR A 169
ALA A 119
 None
 1.27A 5vyhA-4mwgA:
undetectable		 5vyhA-4mwgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		3 / 3 ASP A  43
ARG A  69
ASP A  15
 None
 0.85A 5zvgA-4mwgA:
undetectable		 5zvgA-4mwgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		3 / 3 ASP A  43
ARG A  69
ASP A  15
 None
 0.87A 5zvgB-4mwgA:
undetectable		 5zvgB-4mwgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)
(Paraburkholderia
xenovorans) 		4 / 6 SER A  32
ALA A  97
THR A 101
ALA A  50
 None
None
SO4  A 201 (-3.8A)
None
 1.15A 6ma6A-4mwgA:
undetectable		 6ma6A-4mwgA:
19.07