SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 300
GLY A  56
GLY A  57
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.01A 1dx6A-4mwtA:
8.6		 1dx6A-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 HIS A  35
GLU A  99
ALA A 102
SER A 109
 HIS  A  35 ( 1.0A)
GLU  A  99 ( 0.5A)
ALA  A 102 ( 0.0A)
SER  A 109 ( 0.0A)
 1.11A 1errA-4mwtA:
undetectable
1errB-4mwtA:
undetectable		 1errA-4mwtA:
20.65
1errB-4mwtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 300
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.23A 1maaA-4mwtA:
11.4		 1maaA-4mwtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 GLY A  57
GLU A 149
SER A 150
HIS A 429
 GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 0.79A 1maaD-4mwtA:
11.4		 1maaD-4mwtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 6 SER A 181
ASN A 186
LEU A 190
ASP A 187
 SER  A 181 ( 0.0A)
ASN  A 186 ( 0.6A)
LEU  A 190 ( 0.6A)
ASP  A 187 ( 0.6A)
 1.16A 1mxdA-4mwtA:
undetectable		 1mxdA-4mwtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 SER A 181
ASN A 186
LEU A 190
ASP A 187
 SER  A 181 ( 0.0A)
ASN  A 186 ( 0.6A)
LEU  A 190 ( 0.6A)
ASP  A 187 ( 0.6A)
 1.12A 1mxgA-4mwtA:
undetectable		 1mxgA-4mwtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.40A 1p6kB-4mwtA:
undetectable		 1p6kB-4mwtA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
TYR A  84
GLY A  71
ASN A  90
LEU A  82
 LEU  A  66 ( 0.5A)
TYR  A  84 ( 1.3A)
GLY  A  71 ( 0.0A)
ASN  A  90 ( 0.6A)
LEU  A  82 ( 0.6A)
 1.20A 1pj7A-4mwtA:
1.4		 1pj7A-4mwtA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		6 / 12 ASP A 300
GLY A  56
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.14A 1qtiA-4mwtA:
9.6		 1qtiA-4mwtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.42A 1rs6B-4mwtA:
undetectable		 1rs6B-4mwtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 300
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.03A 1w76A-4mwtA:
13.1		 1w76A-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 10 ASP A 300
GLY A  56
GLY A  57
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.00A 1w76B-4mwtA:
13.4		 1w76B-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 367
PHE A 377
GLU A 149
GLY A 177
 TYR  A 367 ( 1.3A)
PHE  A 377 ( 1.3A)
GLU  A 149 ( 0.5A)
GLY  A 177 ( 0.0A)
 0.98A 1ykiC-4mwtA:
undetectable
1ykiD-4mwtA:
undetectable		 1ykiC-4mwtA:
16.78
1ykiD-4mwtA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 PRO A 329
GLY A 105
ASN A 335
GLY A 103
 PRO  A 329 ( 1.1A)
GLY  A 105 ( 0.0A)
ASN  A 335 ( 0.6A)
GLY  A 103 ( 0.0A)
 1.16A 1zlqA-4mwtA:
undetectable		 1zlqA-4mwtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.41A 1zzqB-4mwtA:
undetectable		 1zzqB-4mwtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.42A 1zzuB-4mwtA:
undetectable		 1zzuB-4mwtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 306
ALA A 309
LEU A  67
LEU A  74
MET A 430
 THR  A 306 ( 0.8A)
ALA  A 309 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  74 ( 0.6A)
MET  A 430 ( 0.0A)
 1.11A 2jfaA-4mwtA:
undetectable		 2jfaA-4mwtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 387
ILE A 419
VAL A 176
PRO A 157
LEU A 174
 LEU  A 387 ( 0.6A)
ILE  A 419 ( 0.6A)
VAL  A 176 ( 0.6A)
PRO  A 157 ( 1.1A)
LEU  A 174 ( 0.5A)
 1.04A 3a51A-4mwtA:
undetectable		 3a51A-4mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 387
ILE A 419
VAL A 176
PRO A 157
LEU A 174
 LEU  A 387 ( 0.6A)
ILE  A 419 ( 0.6A)
VAL  A 176 ( 0.6A)
PRO  A 157 ( 1.1A)
LEU  A 174 ( 0.5A)
 1.09A 3a51D-4mwtA:
undetectable		 3a51D-4mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 305
ASP A 332
GLN A 330
 ASN  A 305 (-0.6A)
ASP  A 332 ( 0.5A)
GLN  A 330 ( 0.6A)
 0.81A 3eeyC-4mwtA:
undetectable		 3eeyC-4mwtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 305
ASP A 332
GLN A 330
 ASN  A 305 (-0.6A)
ASP  A 332 ( 0.5A)
GLN  A 330 ( 0.6A)
 0.80A 3eeyD-4mwtA:
undetectable		 3eeyD-4mwtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 305
ASP A 332
GLN A 330
 ASN  A 305 (-0.6A)
ASP  A 332 ( 0.5A)
GLN  A 330 ( 0.6A)
 0.80A 3eeyE-4mwtA:
undetectable		 3eeyE-4mwtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 306
ALA A 309
LEU A  67
LEU A  74
MET A 430
 THR  A 306 ( 0.8A)
ALA  A 309 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  74 ( 0.6A)
MET  A 430 ( 0.0A)
 1.16A 3hm1A-4mwtA:
undetectable		 3hm1A-4mwtA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 7 TYR A  87
VAL A 413
VAL A 400
ILE A 424
 TYR  A  87 ( 1.3A)
VAL  A 413 ( 0.6A)
VAL  A 400 ( 0.6A)
ILE  A 424 ( 0.4A)
 1.30A 3ms9B-4mwtA:
undetectable		 3ms9B-4mwtA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 11 VAL A 121
GLY A 103
ALA A 102
SER A 100
LEU A  34
 VAL  A 121 ( 0.6A)
GLY  A 103 ( 0.0A)
ALA  A 102 ( 0.0A)
SER  A 100 ( 0.0A)
LEU  A  34 ( 0.6A)
 1.19A 3n8yA-4mwtA:
undetectable		 3n8yA-4mwtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  12
ALA A 308
ALA A 309
THR A  68
LEU A  67
 GLY  A  12 ( 0.0A)
ALA  A 308 ( 0.0A)
ALA  A 309 ( 0.0A)
THR  A  68 ( 0.8A)
LEU  A  67 ( 0.5A)
 1.07A 3p2kA-4mwtA:
undetectable		 3p2kA-4mwtA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 372
GLU A  69
SER A 189
 ASP  A 372 ( 0.6A)
GLU  A  69 ( 0.5A)
SER  A 189 ( 0.0A)
 0.70A 3p2kA-4mwtA:
undetectable		 3p2kA-4mwtA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		3 / 3 LYS A 435
PRO A 436
LEU A 437
 LYS  A 435 ( 0.0A)
PRO  A 436 ( 1.1A)
LEU  A 437 ( 0.6A)
 0.68A 3tpxE-4mwtA:
undetectable		 3tpxE-4mwtA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 155
TYR A 151
ARG A 347
MET A 349
 TYR  A 155 ( 1.3A)
TYR  A 151 ( 1.3A)
ARG  A 347 ( 0.6A)
MET  A 349 ( 0.0A)
 1.49A 3wipC-4mwtA:
undetectable
3wipD-4mwtA:
undetectable		 3wipC-4mwtA:
18.71
3wipD-4mwtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 155
TYR A 151
ARG A 347
MET A 349
 TYR  A 155 ( 1.3A)
TYR  A 151 ( 1.3A)
ARG  A 347 ( 0.6A)
MET  A 349 ( 0.0A)
 1.48A 3wipD-4mwtA:
undetectable
3wipE-4mwtA:
undetectable		 3wipD-4mwtA:
18.71
3wipE-4mwtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 174
GLY A 177
ASP A 380
GLY A 179
SER A 181
 LEU  A 174 ( 0.5A)
GLY  A 177 ( 0.0A)
ASP  A 380 ( 0.5A)
GLY  A 179 ( 0.0A)
SER  A 181 ( 0.0A)
 1.13A 4bwlC-4mwtA:
undetectable		 4bwlC-4mwtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 380
VAL A 413
ASN A 376
 ASP  A 380 ( 0.5A)
VAL  A 413 ( 0.6A)
ASN  A 376 ( 0.6A)
 0.76A 4lmnA-4mwtA:
undetectable		 4lmnA-4mwtA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 7 PRO A 432
GLU A 149
ASP A  78
THR A 311
 PRO  A 432 ( 1.1A)
GLU  A 149 ( 0.5A)
ASP  A  78 ( 0.6A)
THR  A 311 ( 0.8A)
 1.26A 4uacA-4mwtA:
undetectable		 4uacA-4mwtA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 306
ALA A 309
LEU A  67
LEU A  74
MET A 430
 THR  A 306 ( 0.8A)
ALA  A 309 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  74 ( 0.6A)
MET  A 430 ( 0.0A)
 1.28A 4xi3D-4mwtA:
undetectable		 4xi3D-4mwtA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
PHE A 106
LEU A 313
LEU A  67
TYR A 312
 ILE  A   7 ( 0.7A)
PHE  A 106 ( 1.3A)
LEU  A 313 ( 0.6A)
LEU  A  67 ( 0.5A)
TYR  A 312 ( 1.3A)
 1.26A 4xumA-4mwtA:
undetectable		 4xumA-4mwtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 121
GLY A 103
ALA A 102
SER A 100
LEU A  34
 VAL  A 121 ( 0.6A)
GLY  A 103 ( 0.0A)
ALA  A 102 ( 0.0A)
SER  A 100 ( 0.0A)
LEU  A  34 ( 0.6A)
 1.17A 5ikrA-4mwtA:
undetectable		 5ikrA-4mwtA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  54
ALA A 160
ILE A 364
GLY A 173
ILE A 156
 LEU  A  54 ( 0.6A)
ALA  A 160 ( 0.0A)
ILE  A 364 ( 0.7A)
GLY  A 173 ( 0.0A)
ILE  A 156 ( 0.7A)
 1.06A 5kr1A-4mwtA:
undetectable		 5kr1A-4mwtA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 379
GLN A 185
VAL A 384
SER A 181
 GLY  A 379 ( 0.0A)
GLN  A 185 ( 0.6A)
VAL  A 384 ( 0.6A)
SER  A 181 ( 0.0A)
 1.44A 5vunA-4mwtA:
undetectable		 5vunA-4mwtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 PRO A  11
VAL A 318
GLY A  65
VAL A  75
 PRO  A  11 ( 1.1A)
VAL  A 318 ( 0.6A)
GLY  A  65 ( 0.0A)
VAL  A  75 ( 0.6A)
 0.94A 6ak3B-4mwtA:
undetectable		 6ak3B-4mwtA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 PRO A  11
VAL A 318
GLY A  71
VAL A  75
 PRO  A  11 ( 1.1A)
VAL  A 318 ( 0.6A)
GLY  A  71 ( 0.0A)
VAL  A  75 ( 0.6A)
 1.01A 6ak3B-4mwtA:
undetectable		 6ak3B-4mwtA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 121
ASP A 118
LEU A 129
SER A 100
GLY A 153
 VAL  A 121 ( 0.6A)
ASP  A 118 ( 0.6A)
LEU  A 129 ( 0.6A)
SER  A 100 ( 0.0A)
GLY  A 153 ( 0.0A)
 1.14A 6b0lB-4mwtA:
undetectable		 6b0lB-4mwtA:
12.44