SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 THR A  41
ALA A  40
TRP A 255
LEU A 213
ILE A  27
 None
 1.11A 1errA-4mwzA:
undetectable		 1errA-4mwzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 THR A  41
ALA A  40
LEU A 210
LEU A 213
ILE A  27
 None
 1.04A 1errB-4mwzA:
undetectable		 1errB-4mwzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
 None
 1.22A 1errB-4mwzA:
undetectable		 1errB-4mwzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
ILE A  83
ASP A 107
ILE A 108
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
 0.47A 1qaoA-4mwzA:
11.8		 1qaoA-4mwzA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
ILE A  83
ASP A 107
SER A 126
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.2A)
 0.52A 1ri4A-4mwzA:
16.0		 1ri4A-4mwzA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
GLY A  65
ASP A 107
ILE A 108
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
 0.49A 2b25A-4mwzA:
12.7		 2b25A-4mwzA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
GLY A  66
ASP A 107
ILE A 108
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
 0.88A 2b25A-4mwzA:
12.7		 2b25A-4mwzA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 7 TYR A  32
GLY A  62
ASP A  82
ASP A 107
 None
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 1.06A 2g72B-4mwzA:
14.5		 2g72B-4mwzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
ILE A  27
 None
 1.20A 2jfaA-4mwzA:
undetectable		 2jfaA-4mwzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 ASP A  58
GLY A  60
GLY A  62
ILE A  83
LEU A 130
 SAM  A 301 ( 4.6A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
None
 0.68A 2nxeB-4mwzA:
13.0		 2nxeB-4mwzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
ILE A  27
 None
 1.26A 2qxsA-4mwzA:
undetectable		 2qxsA-4mwzA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
ILE A  27
 None
 1.26A 2qxsB-4mwzA:
undetectable		 2qxsB-4mwzA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 8 GLN A 253
LYS A 177
LEU A 180
ARG A 243
 None
 1.10A 2xn3A-4mwzA:
undetectable
2xn3B-4mwzA:
undetectable		 2xn3A-4mwzA:
21.74
2xn3B-4mwzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 8 ILE A 173
TRP A 165
TYR A 172
ARG A 243
 None
None
PO4  A 302 (-4.5A)
None
 1.17A 3ccfB-4mwzA:
18.3		 3ccfB-4mwzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 ASP A  58
GLY A  60
ASP A  82
ILE A  83
LEU A 130
 SAM  A 301 ( 4.6A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.7A)
None
 0.63A 3cjtC-4mwzA:
13.6		 3cjtC-4mwzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
GLY A  64
ASP A 107
ILE A 108
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
 0.89A 3ihtA-4mwzA:
9.0		 3ihtA-4mwzA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
ASP A  82
ASP A 107
ILE A 108
ASP A 125
 SAM  A 301 (-3.7A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
None
 1.27A 3iv6B-4mwzA:
15.0		 3iv6B-4mwzA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 5 TYR A 172
GLN A 253
ILE A 183
PHE A 169
 PO4  A 302 (-4.5A)
None
None
None
 1.27A 3ls4L-4mwzA:
undetectable		 3ls4L-4mwzA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  62
ASP A  58
TYR A 122
LYS A  92
ILE A 101
 SAM  A 301 ( 3.8A)
SAM  A 301 ( 4.6A)
None
None
None
 1.31A 3opeA-4mwzA:
undetectable		 3opeA-4mwzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		3 / 3 GLY A  62
ASP A  82
ASP A 107
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 0.34A 3ou7C-4mwzA:
17.0		 3ou7C-4mwzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 TYR A  16
GLY A  62
MET A  87
ASP A 107
SER A 126
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.9A)
 0.82A 3pfgA-4mwzA:
15.6		 3pfgA-4mwzA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 TYR A  16
ILE A  33
GLY A  60
CYH A  84
ILE A 108
ARG A 124
ASP A 125
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-4.0A)
None
None
 0.74A 3uj6A-4mwzA:
41.6		 3uj6A-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		9 / 12 TYR A  16
ILE A  33
GLY A  60
ILE A  83
ILE A 108
ARG A 124
ASP A 125
HIS A 129
LEU A 130
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-4.0A)
None
None
SAM  A 301 (-3.9A)
None
 0.19A 3uj6A-4mwzA:
41.6		 3uj6A-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 TYR A  16
ILE A  33
GLY A  60
CYH A  84
ILE A 108
ARG A 124
ASP A 125
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-4.0A)
None
None
 0.72A 3uj7A-4mwzA:
41.5		 3uj7A-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		8 / 12 TYR A  16
ILE A  33
GLY A  60
ILE A  83
ILE A 108
ARG A 124
ASP A 125
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-4.0A)
None
None
SAM  A 301 (-3.9A)
 0.18A 3uj7A-4mwzA:
41.5		 3uj7A-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 ILE A  33
GLY A  60
GLY A  62
CYH A  84
ARG A 124
ASP A 125
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
BME  A 303 (-1.9A)
None
None
 0.74A 3uj7B-4mwzA:
41.5		 3uj7B-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		8 / 12 ILE A  33
GLY A  60
GLY A  62
ILE A  83
ARG A 124
ASP A 125
HIS A 129
LEU A 130
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
None
None
SAM  A 301 (-3.9A)
None
 0.18A 3uj7B-4mwzA:
41.5		 3uj7B-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 5 TYR A  16
SER A  34
ASP A  82
ASP A 107
ILE A 108
 SAM  A 301 ( 4.3A)
SAM  A 301 (-2.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
 0.27A 3uj7B-4mwzA:
41.5		 3uj7B-4mwzA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 11 GLY A  62
ASP A  82
ASP A 107
TYR A 157
LEU A 130
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
PO4  A 302 (-4.5A)
None
 0.73A 3v8vB-4mwzA:
11.8		 3v8vB-4mwzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  64
GLY A  65
ASP A  82
ASP A 107
 SAM  A 301 (-3.7A)
None
None
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 0.95A 4b17A-4mwzA:
11.7		 4b17A-4mwzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  64
GLY A  66
ASP A  82
ASP A 107
 SAM  A 301 (-3.7A)
None
None
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 1.10A 4b17A-4mwzA:
11.7		 4b17A-4mwzA:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 7 GLU A 168
TYR A 172
ARG A 176
GLY A 240
LYS A 244
 None
PO4  A 302 (-4.5A)
PO4  A 302 (-3.8A)
None
PO4  A 302 (-2.7A)
 0.85A 4fgzA-4mwzA:
41.8		 4fgzA-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 8 GLY A  29
GLY A  36
TYR A 206
LEU A 210
GLU A 214
 None
 0.23A 4fgzB-4mwzA:
41.8		 4fgzB-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 8 GLU A 168
TYR A 172
ARG A 176
GLY A 240
LYS A 244
 None
PO4  A 302 (-4.5A)
PO4  A 302 (-3.8A)
None
PO4  A 302 (-2.7A)
 1.08A 4fgzA-4mwzA:
41.8
4fgzB-4mwzA:
41.8		 4fgzA-4mwzA:
63.53
4fgzB-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 TYR A  16
GLY A  62
CYH A  84
ILE A  59
HIS A 129
LEU A 130
 SAM  A 301 ( 4.3A)
SAM  A 301 ( 3.8A)
BME  A 303 (-1.9A)
None
SAM  A 301 (-3.9A)
None
 1.17A 4iv0A-4mwzA:
43.0		 4iv0A-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		11 / 12 TYR A  16
ILE A  33
GLY A  60
GLY A  62
ILE A  83
CYH A  84
ILE A 108
ARG A 124
SER A 126
HIS A 129
LEU A 130
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-4.0A)
None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.9A)
None
 0.20A 4iv0A-4mwzA:
43.0		 4iv0A-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 4 SER A  34
ASP A  82
MET A  87
ASP A 107
 SAM  A 301 (-2.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.5A)
 0.09A 4iv0A-4mwzA:
43.0		 4iv0A-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 TYR A  16
GLY A  62
CYH A  84
MET A  87
ILE A  59
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 ( 3.8A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
None
SAM  A 301 (-3.9A)
 0.96A 4iv0B-4mwzA:
44.1		 4iv0B-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		12 / 12 TYR A  16
ILE A  33
GLY A  60
GLY A  62
ILE A  83
CYH A  84
MET A  87
ASP A 107
ILE A 108
ARG A 124
SER A 126
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.9A)
 0.07A 4iv0B-4mwzA:
44.1		 4iv0B-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		11 / 12 GLY A  60
GLY A  62
ASP A  82
ILE A  83
CYH A  84
MET A  87
ASP A 107
ILE A 108
ARG A 124
HIS A 129
LEU A 130
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
None
SAM  A 301 (-3.9A)
None
 0.32A 4iv8A-4mwzA:
36.4		 4iv8A-4mwzA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 GLY A  60
GLY A  62
ASP A  82
MET A  87
ARG A 124
LEU A 138
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.0A)
None
None
 0.97A 4iv8A-4mwzA:
36.4		 4iv8A-4mwzA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 GLY A  62
ASP A  82
CYH A  84
MET A  87
ILE A  59
HIS A 129
LEU A 130
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
None
SAM  A 301 (-3.9A)
None
 1.14A 4iv8A-4mwzA:
36.4		 4iv8A-4mwzA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 GLY A  60
GLY A  62
ASP A  82
CYH A  84
MET A  87
ARG A 124
LEU A 138
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
None
None
 1.00A 4iv8B-4mwzA:
36.4		 4iv8B-4mwzA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		11 / 12 GLY A  60
GLY A  62
ASP A  82
ILE A  83
CYH A  84
MET A  87
ASP A 107
ILE A 108
ARG A 124
HIS A 129
LEU A 130
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
None
SAM  A 301 (-3.9A)
None
 0.35A 4iv8B-4mwzA:
36.4		 4iv8B-4mwzA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 GLY A  62
ASP A  82
CYH A  84
MET A  87
ILE A  59
HIS A 129
LEU A 130
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
None
SAM  A 301 (-3.9A)
None
 1.17A 4iv8B-4mwzA:
36.4		 4iv8B-4mwzA:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 GLY A  62
ASP A  82
ILE A  83
CYH A  84
MET A  87
LEU A 109
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
None
 1.28A 4iv8B-4mwzA:
36.4		 4iv8B-4mwzA:
87.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 TYR A  16
GLY A  60
GLY A  62
ASP A 107
ARG A 124
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.9A)
 0.52A 4krhA-4mwzA:
35.0		 4krhA-4mwzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 TYR A  16
GLY A  60
GLY A  62
ARG A 124
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
None
SAM  A 301 (-3.9A)
 0.52A 4krhB-4mwzA:
35.4		 4krhB-4mwzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 4 ILE A  33
SER A  34
ASP A  82
ASP A 107
 SAM  A 301 (-4.3A)
SAM  A 301 (-2.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 0.66A 4krhB-4mwzA:
35.4		 4krhB-4mwzA:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 TYR A  16
GLY A  62
CYH A  84
MET A  87
ILE A  59
HIS A 129
LEU A 130
 SAM  A 301 ( 4.3A)
SAM  A 301 ( 3.8A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
None
SAM  A 301 (-3.9A)
None
 1.16A 4mwzA-4mwzA:
47.3		 4mwzA-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		12 / 12 TYR A  16
ILE A  33
GLY A  60
GLY A  62
ILE A  83
CYH A  84
MET A  87
ILE A 108
ARG A 124
SER A 126
HIS A 129
LEU A 130
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-3.0A)
SAM  A 301 (-4.0A)
None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.9A)
None
 0.02A 4mwzA-4mwzA:
47.3		 4mwzA-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		3 / 3 SER A  34
ASP A  82
ASP A 107
 SAM  A 301 (-2.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 0.00A 4mwzA-4mwzA:
47.3		 4mwzA-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 8 GLY A  29
GLY A  36
ILE A  39
GLU A 209
LEU A 210
GLU A 214
LYS A 217
 None
 0.36A 4mwzB-4mwzA:
undetectable		 4mwzB-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 8 GLY A  36
LEU A 210
LEU A 213
GLU A 214
 None
 0.61A 4mwzB-4mwzA:
undetectable		 4mwzB-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 TYR A  16
GLY A  62
CYH A  84
ILE A  59
HIS A 129
LEU A 130
 SAM  A 301 ( 4.3A)
SAM  A 301 ( 3.8A)
BME  A 303 (-1.9A)
None
SAM  A 301 (-3.9A)
None
 1.16A 4mwzB-4mwzA:
42.9		 4mwzB-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		11 / 12 TYR A  16
ILE A  33
GLY A  60
GLY A  62
ILE A  83
CYH A  84
ILE A 108
ARG A 124
SER A 126
HIS A 129
LEU A 130
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-4.0A)
None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.9A)
None
 0.24A 4mwzB-4mwzA:
42.9		 4mwzB-4mwzA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 4 SER A  34
ASP A  82
MET A  87
ASP A 107
 SAM  A 301 (-2.4A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.5A)
 0.07A 4mwzB-4mwzA:
42.9		 4mwzB-4mwzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 ILE A  44
THR A  41
THR A 155
LEU A  45
ASP A  58
 None
None
None
None
SAM  A 301 ( 4.6A)
 1.30A 4pbhA-4mwzA:
undetectable		 4pbhA-4mwzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
ILE A  83
MET A  87
HIS A 129
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.9A)
 0.89A 4qdjA-4mwzA:
17.4		 4qdjA-4mwzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		3 / 3 MET A 181
GLU A 185
LEU A 189
 None
 0.77A 4v2oB-4mwzA:
undetectable		 4v2oB-4mwzA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
 None
 1.31A 4xi3D-4mwzA:
undetectable		 4xi3D-4mwzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  62
ASP A  58
TYR A 122
LYS A  92
ILE A 101
 SAM  A 301 ( 3.8A)
SAM  A 301 ( 4.6A)
None
None
None
 1.33A 4ynpA-4mwzA:
undetectable		 4ynpA-4mwzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 ILE A  33
GLY A  65
ILE A  83
MET A  87
LEU A 130
 SAM  A 301 (-4.3A)
None
SAM  A 301 (-3.7A)
SAM  A 301 (-3.0A)
None
 0.98A 5e72A-4mwzA:
14.7		 5e72A-4mwzA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 4 ASP A  58
GLY A  62
ASP A  82
ASP A 107
 SAM  A 301 ( 4.6A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 0.65A 5e72A-4mwzA:
14.7		 5e72A-4mwzA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  62
MET A  87
SER A 126
HIS A 129
LEU A 130
 SAM  A 301 ( 3.8A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.9A)
None
 0.81A 5gwxA-4mwzA:
17.2		 5gwxA-4mwzA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		3 / 3 TYR A 178
TYR A  24
GLN A  15
 PO4  A 302 (-4.6A)
PO4  A 302 (-4.6A)
PO4  A 302 (-4.0A)
 1.07A 5jsdA-4mwzA:
undetectable
5jsdB-4mwzA:
undetectable		 5jsdA-4mwzA:
17.10
5jsdB-4mwzA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		3 / 3 TYR A 178
TYR A  24
GLN A  15
 PO4  A 302 (-4.6A)
PO4  A 302 (-4.6A)
PO4  A 302 (-4.0A)
 1.07A 5jsdB-4mwzA:
undetectable
5jsdC-4mwzA:
undetectable		 5jsdB-4mwzA:
17.10
5jsdC-4mwzA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 8 LEU A  50
LEU A 153
ILE A  38
THR A  41
 None
 1.05A 5ljbA-4mwzA:
undetectable		 5ljbA-4mwzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
ASP A  82
HIS A 129
LEU A 130
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.9A)
None
 0.68A 5wy0A-4mwzA:
13.1		 5wy0A-4mwzA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  60
GLY A  62
ASP A  82
ILE A  83
LEU A 130
 SAM  A 301 (-3.7A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.7A)
None
 0.45A 5wy0A-4mwzA:
13.1		 5wy0A-4mwzA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 GLY A  62
LEU A  63
GLY A  65
ASP A 107
ILE A 108
 SAM  A 301 ( 3.8A)
None
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.0A)
 0.58A 6mhtA-4mwzA:
8.0		 6mhtA-4mwzA:
20.41