SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 12 LEU A 350
LEU A 347
VAL A 346
SER A 343
SER A 377
 None
 1.29A 1db1A-4mx2A:
undetectable		 1db1A-4mx2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 12 GLY A 373
SER A 343
HIS A 291
LEU A 354
LEU A 223
 None
 1.49A 1fm6D-4mx2A:
undetectable		 1fm6D-4mx2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		4 / 7 GLY A 146
PHE A 232
ILE A 152
PHE A 258
 None
 0.99A 2qmzA-4mx2A:
undetectable
2qmzB-4mx2A:
undetectable		 2qmzA-4mx2A:
19.70
2qmzB-4mx2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		3 / 3 ALA A 384
ARG A 388
LYS A 392
 None
 0.96A 3kp5B-4mx2A:
0.9		 3kp5B-4mx2A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 10 ILE A 213
PHE A 333
ALA A 382
LEU A 386
ALA A 298
 None
 1.43A 3lw5B-4mx2A:
1.5		 3lw5B-4mx2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		3 / 3 LYS A 456
ARG A 421
LEU A 464
 None
 1.41A 3v4tE-4mx2A:
undetectable		 3v4tE-4mx2A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 12 GLU A 413
VAL A 410
PRO A 202
THR A 203
GLU A 208
 None
 1.33A 4k88A-4mx2A:
undetectable		 4k88A-4mx2A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		4 / 8 SER A 357
ASP A 362
VAL A 368
THR A 367
 None
None
None
AMP  A 501 (-4.4A)
 1.12A 4lnwA-4mx2A:
undetectable		 4lnwA-4mx2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA703_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		4 / 4 LEU A  67
PHE A  98
LEU A  90
GLU A  70
 None
 1.46A 4p7nA-4mx2A:
undetectable		 4p7nA-4mx2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 12 LEU A  57
THR A 148
VAL A 123
ALA A 122
ILE A 152
 None
 1.11A 4x1kD-4mx2A:
undetectable		 4x1kD-4mx2A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 11 LEU A 380
ALA A 382
LEU A 294
LEU A 340
LEU A 176
 None
 1.25A 4zn7B-4mx2A:
undetectable		 4zn7B-4mx2A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		4 / 8 SER A 343
HIS A 291
LEU A 376
LEU A 380
 None
 0.94A 5dzkd-4mx2A:
undetectable
5dzkr-4mx2A:
undetectable		 5dzkd-4mx2A:
19.05
5dzkr-4mx2A:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		4 / 6 SER A 343
HIS A 291
LEU A 376
LEU A 380
 None
 1.25A 5dzke-4mx2A:
undetectable
5dzks-4mx2A:
undetectable		 5dzke-4mx2A:
19.05
5dzks-4mx2A:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		3 / 3 THR A  86
ASP A  87
ALA A  88
 None
 0.07A 5g5gB-4mx2A:
undetectable		 5g5gB-4mx2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 12 GLU A 413
VAL A 410
PRO A 202
THR A 203
GLU A 208
 None
 1.27A 5xipD-4mx2A:
undetectable		 5xipD-4mx2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 12 LEU A 192
GLU A 413
VAL A 410
PRO A 202
GLU A 208
 None
 1.46A 5xipD-4mx2A:
undetectable		 5xipD-4mx2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4mx2 ADENYLOSUCCINATE
LYASE
(Leishmania
donovani) 		5 / 11 SER A 385
ARG A 388
ALA A 382
THR A  45
LEU A  37
 None
 1.31A 6efnA-4mx2A:
undetectable		 6efnA-4mx2A:
23.36