SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ASN A 171
LEU A 201
GLU A 200
TYR A 229
ARG A 241
 None
CMP  A 401 (-3.4A)
CMP  A 401 (-2.9A)
None
None
 1.48A 1l5rA-4mx3A:
undetectable		 1l5rA-4mx3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 6 PRO A 351
LEU A 327
ARG A 355
GLY A 358
 None
 1.04A 2hs2B-4mx3A:
undetectable		 2hs2B-4mx3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 5 SER A 191
LEU A 221
GLY A 196
GLU A 179
 None
 1.14A 3aiaA-4mx3A:
undetectable
3aiaB-4mx3A:
undetectable		 3aiaA-4mx3A:
20.00
3aiaB-4mx3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 4 LEU A 248
ARG A 355
LEU A 357
ALA A 268
 None
 1.10A 3b9mA-4mx3A:
undetectable		 3b9mA-4mx3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ASN A 133
VAL A 174
GLY A 223
ILE A 147
LEU A 233
 None
 1.05A 3bexC-4mx3A:
undetectable
3bexD-4mx3A:
undetectable		 3bexC-4mx3A:
22.66
3bexD-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 10 LEU A 233
ASN A 133
VAL A 174
GLY A 223
ILE A 147
 None
 1.05A 3bexC-4mx3A:
undetectable
3bexD-4mx3A:
undetectable		 3bexC-4mx3A:
22.66
3bexD-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 10 ASN A 133
VAL A 174
GLY A 223
ILE A 147
LEU A 233
 None
 1.05A 3bexE-4mx3A:
undetectable
3bexF-4mx3A:
undetectable		 3bexE-4mx3A:
22.66
3bexF-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 LEU A 233
ASN A 133
VAL A 174
GLY A 223
ILE A 147
 None
 1.03A 3bexE-4mx3A:
undetectable
3bexF-4mx3A:
undetectable		 3bexE-4mx3A:
22.66
3bexF-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ASN A 133
VAL A 174
GLY A 223
ILE A 147
LEU A 233
 None
 1.08A 3bf1A-4mx3A:
undetectable
3bf1B-4mx3A:
undetectable		 3bf1A-4mx3A:
22.66
3bf1B-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 LEU A 233
ASN A 133
VAL A 174
GLY A 223
ILE A 147
 None
 1.05A 3bf1A-4mx3A:
undetectable
3bf1B-4mx3A:
undetectable		 3bf1A-4mx3A:
22.66
3bf1B-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ASN A 133
VAL A 174
GLY A 223
ILE A 147
LEU A 233
 None
 1.06A 3bf1C-4mx3A:
undetectable
3bf1D-4mx3A:
undetectable		 3bf1C-4mx3A:
22.66
3bf1D-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 LEU A 233
ASN A 133
VAL A 174
GLY A 223
ILE A 147
 None
 1.05A 3bf1C-4mx3A:
undetectable
3bf1D-4mx3A:
undetectable		 3bf1C-4mx3A:
22.66
3bf1D-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ASN A 133
VAL A 174
GLY A 223
ILE A 147
LEU A 233
 None
 1.05A 3bf1E-4mx3A:
undetectable
3bf1F-4mx3A:
undetectable		 3bf1E-4mx3A:
22.66
3bf1F-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 LEU A 233
ASN A 133
VAL A 174
GLY A 223
ILE A 147
 None
 1.05A 3bf1E-4mx3A:
undetectable
3bf1F-4mx3A:
undetectable		 3bf1E-4mx3A:
22.66
3bf1F-4mx3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		3 / 3 ARG A 262
VAL A 192
THR A 190
 None
 0.81A 3k4vD-4mx3A:
undetectable		 3k4vD-4mx3A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 6 SER A 197
PHE A 172
PHE A 136
ASN A 133
 None
 1.18A 3lskB-4mx3A:
undetectable		 3lskB-4mx3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 6 SER A 197
PHE A 172
PHE A 136
ASN A 133
 None
 1.25A 3lskD-4mx3A:
undetectable		 3lskD-4mx3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ILE A 163
ALA A 211
PHE A 198
LEU A 221
VAL A 162
 CMP  A 401 ( 4.2A)
CMP  A 401 ( 3.8A)
None
None
None
 1.14A 3n0hA-4mx3A:
undetectable		 3n0hA-4mx3A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 ILE A 163
ALA A 211
PHE A 198
LEU A 221
VAL A 162
 CMP  A 401 ( 4.2A)
CMP  A 401 ( 3.8A)
None
None
None
 1.11A 3s3vA-4mx3A:
undetectable		 3s3vA-4mx3A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		3 / 3 GLN A 273
GLU A 295
LYS A 344
 None
 1.18A 3su9A-4mx3A:
undetectable		 3su9A-4mx3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 ASN A 133
VAL A 174
GLY A 223
ILE A 147
LEU A 233
 None
 1.02A 4o5fA-4mx3A:
undetectable
4o5fB-4mx3A:
undetectable		 4o5fA-4mx3A:
22.68
4o5fB-4mx3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 LEU A 233
ASN A 133
VAL A 174
GLY A 223
ILE A 147
 None
 1.04A 4o5fA-4mx3A:
undetectable
4o5fB-4mx3A:
undetectable		 4o5fA-4mx3A:
22.68
4o5fB-4mx3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 5 ASP A 288
VAL A 281
PHE A 291
GLY A 323
 None
None
None
CMP  A 402 (-3.5A)
 0.98A 4xp6A-4mx3A:
undetectable		 4xp6A-4mx3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 ASN A 133
VAL A 174
GLY A 223
ILE A 147
LEU A 233
 None
 1.08A 5b8hA-4mx3A:
undetectable
5b8hB-4mx3A:
undetectable		 5b8hA-4mx3A:
20.88
5b8hB-4mx3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 LEU A 233
ASN A 133
VAL A 174
GLY A 223
ILE A 147
 None
 1.09A 5b8hA-4mx3A:
undetectable
5b8hB-4mx3A:
undetectable		 5b8hA-4mx3A:
20.88
5b8hB-4mx3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 LEU A 327
LEU A 257
LEU A 254
PHE A 290
ALA A 268
 None
 1.35A 5ieoA-4mx3A:
undetectable		 5ieoA-4mx3A:
18.21