SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 11 PHE A 234
LEU A 245
VAL A 247
VAL A 271
THR A 274
 None
 1.23A 1q23F-4mx8A:
undetectable		 1q23F-4mx8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 12 GLU A  27
ASN A  22
ASP A 128
GLY A 111
PHE A 294
 None
 1.41A 1q8jA-4mx8A:
undetectable		 1q8jA-4mx8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.31A 1usqB-4mx8A:
undetectable		 1usqB-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.31A 1usqC-4mx8A:
undetectable		 1usqC-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.32A 1usqD-4mx8A:
undetectable		 1usqD-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.31A 1usqE-4mx8A:
undetectable		 1usqE-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		6 / 12 ARG A 132
GLY A 295
ALA A  53
ASP A  56
VAL A  49
ILE A  58
 None
 1.27A 2avoB-4mx8A:
undetectable		 2avoB-4mx8A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 7 LEU A 131
GLY A 295
THR A 300
ILE A 167
 None
 0.73A 2bdmA-4mx8A:
undetectable		 2bdmA-4mx8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 11 LEU A  81
LEU A  91
MET A  52
SER A  72
LEU A  70
 None
 1.25A 2c12F-4mx8A:
undetectable		 2c12F-4mx8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.35A 2jkjA-4mx8A:
undetectable		 2jkjA-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.35A 2jkjB-4mx8A:
undetectable		 2jkjB-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.35A 2jkjC-4mx8A:
undetectable		 2jkjC-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 6 PRO A 218
GLY A 181
ILE A 184
GLY A 183
TYR A 211
 None
 1.30A 2jklB-4mx8A:
undetectable		 2jklB-4mx8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 10 ILE A  65
ALA A  54
LEU A 146
LEU A 106
ILE A  47
 None
 1.19A 2w9sD-4mx8A:
undetectable		 2w9sD-4mx8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 10 ILE A  65
ALA A  54
LEU A 146
LEU A 106
ILE A  47
 None
 1.19A 2w9sF-4mx8A:
undetectable		 2w9sF-4mx8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 TRP A 246
VAL A 219
TRP A 244
 None
 1.27A 2xdcC-4mx8A:
undetectable
2xdcD-4mx8A:
undetectable		 2xdcC-4mx8A:
6.48
2xdcD-4mx8A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 TRP A 246
VAL A 219
TRP A 244
 None
 1.26A 2xdcE-4mx8A:
undetectable
2xdcF-4mx8A:
undetectable		 2xdcE-4mx8A:
6.48
2xdcF-4mx8A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 TRP A 246
VAL A 219
TRP A 244
 None
 1.23A 2y5mE-4mx8A:
undetectable
2y5mF-4mx8A:
undetectable		 2y5mE-4mx8A:
6.48
2y5mF-4mx8A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 TRP A 246
VAL A 219
TRP A 244
 None
 1.26A 2y6nC-4mx8A:
undetectable
2y6nD-4mx8A:
undetectable		 2y6nC-4mx8A:
6.48
2y6nD-4mx8A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 TRP A 246
VAL A 219
TRP A 244
 None
 1.26A 2y6nE-4mx8A:
undetectable
2y6nF-4mx8A:
undetectable		 2y6nE-4mx8A:
6.48
2y6nF-4mx8A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 11 LEU A 146
ALA A  53
ALA A  54
VAL A 149
LEU A 106
 None
 1.28A 3bszE-4mx8A:
undetectable		 3bszE-4mx8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 11 ALA A 262
LEU A 191
LEU A 245
VAL A 282
ASN A 268
 None
 1.06A 3jw5A-4mx8A:
undetectable		 3jw5A-4mx8A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA206_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 4 ASP A 251
ARG A 250
THR A 254
ALA A 256
 None
 1.19A 3mbgA-4mx8A:
undetectable		 3mbgA-4mx8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 7 ASP A 251
ARG A 250
THR A 254
ALA A 256
 None
 1.22A 3mbgA-4mx8A:
undetectable
3mbgB-4mx8A:
undetectable		 3mbgA-4mx8A:
16.35
3mbgB-4mx8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 7 ILE A 184
LEU A 266
ALA A 276
ALA A 277
 None
 0.86A 3r9tB-4mx8A:
undetectable		 3r9tB-4mx8A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 6 LEU A 139
ALA A  53
ASP A  51
THR A  57
 None
 1.09A 3rozA-4mx8A:
undetectable		 3rozA-4mx8A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 12 ILE A  65
ALA A  82
ALA A  85
VAL A 108
ILE A 107
 None
 1.21A 3uvvB-4mx8A:
undetectable		 3uvvB-4mx8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 SER A 195
ASP A 201
ASP A  30
 None
 0.75A 4mwzA-4mx8A:
undetectable		 4mwzA-4mx8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 5 ILE A  58
LEU A 146
ASP A  51
VAL A  38
 None
 1.01A 4nkxB-4mx8A:
undetectable		 4nkxB-4mx8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 5 GLY A 147
LEU A 129
ILE A  58
LEU A 106
 None
 0.85A 4o8fA-4mx8A:
undetectable		 4o8fA-4mx8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 8 PHE A 214
ILE A 167
TRP A 290
PHE A 294
 None
 0.79A 4qogA-4mx8A:
2.1
4qogB-4mx8A:
2.1		 4qogA-4mx8A:
21.88
4qogB-4mx8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 5 LEU A 129
ASP A  51
LEU A 146
THR A 138
 None
 1.20A 4wozF-4mx8A:
undetectable
4wozH-4mx8A:
undetectable		 4wozF-4mx8A:
22.03
4wozH-4mx8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 6 TYR A  17
GLY A 110
SER A 130
LEU A 129
 None
 1.14A 5bphA-4mx8A:
4.2		 5bphA-4mx8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 7 TYR A  17
GLY A 110
SER A 130
LEU A 129
 None
 1.16A 5bphB-4mx8A:
3.8		 5bphB-4mx8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 4 TYR A  17
GLY A 110
SER A 130
LEU A 129
 None
 1.10A 5bphC-4mx8A:
4.2		 5bphC-4mx8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 6 TYR A  17
GLY A 110
SER A 130
LEU A 129
 None
 1.10A 5bphD-4mx8A:
3.3		 5bphD-4mx8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 12 GLY A 207
GLY A 204
PRO A 196
ILE A 210
LEU A 194
 None
 1.13A 5bw4A-4mx8A:
undetectable		 5bw4A-4mx8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 10 TYR A 135
ASP A  56
TYR A  76
ILE A 302
LEU A 163
 None
 1.17A 5fxfB-4mx8A:
undetectable		 5fxfB-4mx8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 8 GLY A  67
ILE A  65
ASP A  84
ASP A  83
 None
 1.05A 6ag0C-4mx8A:
undetectable		 6ag0C-4mx8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 9 LEU A 209
MET A 303
VAL A 213
LEU A 163
ILE A 167
 None
 1.20A 6fdyU-4mx8A:
undetectable		 6fdyU-4mx8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4mx8 PERIPLASMIC BINDING
PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 9 LEU A 191
SER A 233
PHE A 234
GLU A 235
VAL A 265
 None
 1.30A 6ftpA-4mx8A:
undetectable
6ftpB-4mx8A:
undetectable		 6ftpA-4mx8A:
12.17
6ftpB-4mx8A:
7.74