SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		5 / 12 LEU A 791
LEU A 709
MET A 669
ILE A 766
VAL A 682
 None
 1.29A 1hrkB-4mxeA:
undetectable		 1hrkB-4mxeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		5 / 12 LEU A 791
LEU A 709
MET A 669
ILE A 766
VAL A 682
 None
 1.33A 2pnjB-4mxeA:
undetectable		 2pnjB-4mxeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		3 / 3 ARG A 792
SER A 793
TYR A 822
 None
 1.03A 2q2hA-4mxeA:
undetectable
2q2hB-4mxeA:
undetectable		 2q2hA-4mxeA:
19.42
2q2hB-4mxeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		4 / 7 TYR A 731
SER A 759
CYH A 758
ILE A 834
 None
 0.99A 2xz5A-4mxeA:
undetectable
2xz5B-4mxeA:
undetectable		 2xz5A-4mxeA:
21.46
2xz5B-4mxeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		4 / 8 TYR A 731
SER A 759
CYH A 758
ILE A 834
 None
 1.09A 2xz5B-4mxeA:
undetectable
2xz5E-4mxeA:
undetectable		 2xz5B-4mxeA:
21.46
2xz5E-4mxeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		5 / 12 LEU A 791
LEU A 709
MET A 669
ILE A 766
VAL A 682
 None
 1.28A 3aqiB-4mxeA:
undetectable		 3aqiB-4mxeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		5 / 12 GLY A 768
ILE A 766
ILE A 806
ARG A 771
ALA A 724
 None
 1.09A 3uj7A-4mxeA:
undetectable		 3uj7A-4mxeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4mxe N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		5 / 12 LEU A 791
LEU A 709
MET A 669
ILE A 766
VAL A 682
 None
 1.26A 3w1wA-4mxeA:
undetectable		 3w1wA-4mxeA:
21.74