SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4mxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		5 / 12 VAL Y 219
LEU Y 163
LEU Y 135
GLY Y 216
LEU Y 127
 None
 1.06A 2aylA-4mxwY:
undetectable		 2aylA-4mxwY:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		5 / 12 VAL Y 219
LEU Y 163
LEU Y 135
GLY Y 216
LEU Y 127
 None
 1.08A 2aylB-4mxwY:
undetectable		 2aylB-4mxwY:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		4 / 4 LEU Y 113
THR Y 114
ILE Y  93
HIS Y  91
 None
 1.22A 2jfaB-4mxwY:
undetectable		 2jfaB-4mxwY:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		4 / 7 TYR Y 136
ALA Y  89
THR Y 117
LEU Y 125
 None
 0.95A 2wx2A-4mxwY:
undetectable		 2wx2A-4mxwY:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		4 / 8 TYR Y 136
ALA Y  89
THR Y 117
LEU Y 125
 None
 0.93A 3l4dA-4mxwY:
undetectable		 3l4dA-4mxwY:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		3 / 3 TYR Y 220
ARG Y 160
SER Y 162
 None
 1.03A 4khpI-4mxwY:
undetectable
4khpJ-4mxwY:
undetectable		 4khpI-4mxwY:
20.48
4khpJ-4mxwY:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		5 / 9 VAL Y 219
LEU Y 163
LEU Y 135
GLY Y 216
LEU Y 127
 None
 1.10A 4rs0A-4mxwY:
undetectable		 4rs0A-4mxwY:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		4 / 6 ALA Y 126
GLN Y 118
LEU Y 127
LEU Y 113
 None
 0.97A 4xoyA-4mxwY:
undetectable		 4xoyA-4mxwY:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		4 / 6 ALA Y 126
GLN Y 118
LEU Y 127
LEU Y 113
 None
 0.93A 4xp3A-4mxwY:
undetectable		 4xp3A-4mxwY:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		4 / 7 SER Y 161
ASP Y 121
GLY Y  94
GLU Y 105
 None
 0.91A 5btfA-4mxwY:
undetectable
5btfB-4mxwY:
undetectable
5btfC-4mxwY:
undetectable		 5btfA-4mxwY:
16.93
5btfB-4mxwY:
21.71
5btfC-4mxwY:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4mxw TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 3
(Homo
sapiens) 		4 / 6 PRO S  64
GLY S  65
THR S  66
ASN S  89
 None
 1.09A 5xxiA-4mxwS:
undetectable		 5xxiA-4mxwS:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4mxw LYMPHOTOXIN-BETA
(Homo
sapiens) 		5 / 9 TYR Y 136
ALA Y  89
THR Y 117
LEU Y 125
LEU Y 213
 None
 0.93A 6ay6A-4mxwY:
undetectable		 6ay6A-4mxwY:
17.38