SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4my0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 12 VAL A 301
LEU A 319
LEU A 340
LEU A 303
LEU A 357
 None
 1.01A 1mx1F-4my0A:
undetectable		 1mx1F-4my0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 6 PRO A 188
ALA A 193
GLU A 197
GLU A 194
 None
 1.08A 1qhyA-4my0A:
undetectable		 1qhyA-4my0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 TYR A 213
TYR A 204
GLY A 241
THR A 239
 None
 1.02A 2g70A-4my0A:
undetectable		 2g70A-4my0A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 TYR A 213
TYR A 204
GLY A 241
THR A 239
 None
 1.03A 2g70B-4my0A:
undetectable		 2g70B-4my0A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 6 ARG A 291
GLY A 292
PHE A 293
PRO A 295
 None
 1.32A 2m2oB-4my0A:
undetectable		 2m2oB-4my0A:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 6 LEU A 386
ASP A 387
TRP A 187
ILE A 192
 None
 0.98A 2rlfB-4my0A:
undetectable
2rlfC-4my0A:
undetectable		 2rlfB-4my0A:
7.45
2rlfC-4my0A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 GLU A  90
ARG A  94
GLU A  58
SER A  55
 None
 1.21A 2zt7A-4my0A:
undetectable		 2zt7A-4my0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 PHE A 293
PHE A 378
TYR A 349
GLY A 135
 None
 1.09A 3em0B-4my0A:
undetectable		 3em0B-4my0A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 8 SER A 342
LEU A 282
ALA A 287
ALA A 284
 None
 0.97A 3ns1L-4my0A:
undetectable		 3ns1L-4my0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 10 LEU A 345
LEU A 348
SER A 320
LEU A 319
LEU A 338
 None
 1.00A 4yiaA-4my0A:
undetectable		 4yiaA-4my0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		6 / 12 THR A 352
GLY A 134
GLN A  70
ILE A 115
ALA A 346
GLY A 344
 None
 1.46A 5kb6A-4my0A:
undetectable		 5kb6A-4my0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		6 / 12 THR A 352
GLY A 134
GLN A  70
ILE A 115
ALA A 346
GLY A 344
 None
 1.46A 5kb6B-4my0A:
undetectable		 5kb6B-4my0A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4my0 GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 6 ILE A  82
TYR A 131
LEU A 129
VAL A 104
 None
 1.15A 6f6jA-4my0A:
undetectable		 6f6jA-4my0A:
undetectable