SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4my2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP A 160
VAL A 261
TRP A 342
 None
None
MAL  A1201 (-3.6A)
 1.30A 1c4dA-4my2A:
undetectable
1c4dB-4my2A:
undetectable		 1c4dA-4my2A:
5.21
1c4dB-4my2A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A  10
VAL A  52
ILE A  62
ASN A 269
 None
 0.95A 1e06A-4my2A:
undetectable		 1e06A-4my2A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 9 ALA A 278
ILE A  11
VAL A  37
ILE A   4
ILE A  62
ILE A  61
 None
 1.46A 1hshB-4my2A:
undetectable		 1hshB-4my2A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 GLU A 113
TRP A 232
LYS A 275
 MAL  A1201 (-3.1A)
MAL  A1201 ( 4.6A)
None
 1.20A 1qu2A-4my2A:
undetectable		 1qu2A-4my2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A 305
ILE A 110
VAL A  99
LEU A  78
ILE A  81
 None
 1.23A 2h42A-4my2A:
undetectable		 2h42A-4my2A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ALA A 190
LEU A 194
ALA A 348
THR A 347
 None
 0.92A 3b6hA-4my2A:
undetectable		 3b6hA-4my2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE A 260
ALA A 164
LEU A 249
PRO A 161
 None
 0.96A 3bgdA-4my2A:
undetectable		 3bgdA-4my2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASP A  16
LEU A  45
LEU A  22
TRP A  64
 MAL  A1201 (-3.0A)
None
None
MAL  A1201 (-4.3A)
 1.27A 3bj8C-4my2A:
undetectable
3bj8D-4my2A:
undetectable		 3bj8C-4my2A:
16.81
3bj8D-4my2A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 112
GLY A 302
PRO A 231
LYS A 307
 None
 0.79A 3bjwC-4my2A:
undetectable		 3bjwC-4my2A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 128
LEU A 149
ALA A 225
PRO A 127
 None
 1.34A 3gv1A-4my2A:
undetectable
3gv1C-4my2A:
undetectable		 3gv1A-4my2A:
14.01
3gv1C-4my2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.33A 3gv1A-4my2A:
undetectable
3gv1B-4my2A:
undetectable		 3gv1A-4my2A:
14.01
3gv1B-4my2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 345
GLY A 189
ALA A 190
LEU A 194
LEU A 162
 None
 1.05A 3hs6A-4my2A:
undetectable		 3hs6A-4my2A:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A  16
LYS A  17
LYS A  44
GLU A  46
GLU A  47
ALA A  65
ARG A  68
GLU A 113
TRP A 232
 MAL  A1201 (-3.0A)
MAL  A1201 (-2.5A)
None
None
None
MAL  A1201 (-3.2A)
MAL  A1201 (-3.9A)
MAL  A1201 (-3.1A)
MAL  A1201 ( 4.6A)
 0.77A 3jyrA-4my2A:
62.0		 3jyrA-4my2A:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		10 / 12 ASP A  16
LYS A  17
LYS A  44
GLU A  46
GLU A  47
ALA A  65
ASP A  67
GLU A 113
PRO A 156
TRP A 232
 MAL  A1201 (-3.0A)
MAL  A1201 (-2.5A)
None
None
None
MAL  A1201 (-3.2A)
MAL  A1201 (-2.8A)
MAL  A1201 (-3.1A)
MAL  A1201 (-3.7A)
MAL  A1201 ( 4.6A)
 0.51A 3jyrA-4my2A:
62.0		 3jyrA-4my2A:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 7 ASN A  14
TRP A  64
GLU A 155
TYR A 157
MET A 332
TRP A 342
 MAL  A1201 (-3.9A)
MAL  A1201 (-4.3A)
MAL  A1201 (-3.6A)
MAL  A1201 (-3.9A)
MAL  A1201 ( 4.3A)
MAL  A1201 (-3.6A)
 0.27A 3jyrA-4my2A:
62.0		 3jyrA-4my2A:
77.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ALA A1105
ARG A1107
LYS A1058
 None
 1.06A 3kp3B-4my2A:
undetectable		 3kp3B-4my2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 None
None
None
MAL  A1201 (-3.1A)
None
 0.83A 3tbgB-4my2A:
undetectable		 3tbgB-4my2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 158
GLY A 302
LEU A 301
GLU A 113
ALA A 233
 None
None
None
MAL  A1201 (-3.1A)
None
 0.82A 3tbgD-4my2A:
undetectable		 3tbgD-4my2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 GLU A 310
ASP A 316
ASP A 289
ASN A 296
 None
 1.36A 3vywD-4my2A:
undetectable		 3vywD-4my2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 GLY A  18
VAL A 295
PRO A 300
GLY A 302
 None
 0.85A 4dxuA-4my2A:
5.0		 4dxuA-4my2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 268
ALA A 107
LEU A  22
VAL A  25
ILE A  61
 None
 1.08A 4m2xG-4my2A:
undetectable		 4m2xG-4my2A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
MAL  A1201 (-3.0A)
 0.96A 4n48A-4my2A:
undetectable		 4n48A-4my2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 185
LEU A 363
ALA A 348
ILE A 228
ILE A 163
 None
 1.08A 5hbsA-4my2A:
undetectable		 5hbsA-4my2A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 344
ALA A 340
GLY A 168
ALA A 190
PHE A 171
VAL A 183
 None
 1.43A 5w4zA-4my2A:
undetectable		 5w4zA-4my2A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 344
ALA A 340
GLY A 168
ALA A 190
PHE A 171
VAL A 183
 None
 1.46A 5w4zB-4my2A:
undetectable		 5w4zB-4my2A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 157
ASN A 229
LEU A 115
 MAL  A1201 (-3.9A)
None
None
 0.80A 6b58A-4my2A:
undetectable		 6b58A-4my2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO A 135
GLU A 132
PRO A 256
ALA A 165
PRO A 161
 None
 1.44A 6bm5A-4my2A:
undetectable		 6bm5A-4my2A:
22.78