SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4my5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 8 TYR A  88
LEU A 225
LEU A  86
SER A 220
 None
 1.05A 1i7zA-4my5A:
undetectable		 1i7zA-4my5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 SER A 335
PHE A 324
GLU A 361
GLY A 360
 None
 0.91A 1icuA-4my5A:
undetectable
1icuB-4my5A:
undetectable		 1icuA-4my5A:
21.91
1icuB-4my5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 PHE A 324
GLU A 361
GLY A 360
SER A 335
 None
 0.84A 1icuA-4my5A:
undetectable
1icuB-4my5A:
undetectable		 1icuA-4my5A:
21.91
1icuB-4my5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 SER A 335
PHE A 324
GLU A 361
GLY A 360
 None
 0.90A 1icuC-4my5A:
undetectable
1icuD-4my5A:
undetectable		 1icuC-4my5A:
21.91
1icuD-4my5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 SER A 335
PHE A 324
GLU A 361
GLY A 360
 None
 0.93A 1kqbA-4my5A:
undetectable
1kqbB-4my5A:
undetectable		 1kqbA-4my5A:
22.44
1kqbB-4my5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 SER A 335
PHE A 324
GLU A 361
GLY A 360
 None
 0.87A 1kqbC-4my5A:
undetectable
1kqbD-4my5A:
undetectable		 1kqbC-4my5A:
22.44
1kqbD-4my5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 PHE A 324
GLU A 361
GLY A 360
SER A 335
 None
 0.98A 1kqbC-4my5A:
undetectable
1kqbD-4my5A:
undetectable		 1kqbC-4my5A:
22.44
1kqbD-4my5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 8 ASP A  91
ASN A  92
SER A  77
ALA A 253
 None
 1.20A 1rqpC-4my5A:
2.3		 1rqpC-4my5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 5 ILE A  14
SER A 105
LEU A 134
ASN A 133
 None
 1.17A 1y0xX-4my5A:
undetectable		 1y0xX-4my5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 12 ILE A 327
PRO A 328
ILE A 366
PHE A 312
TYR A 389
 None
 1.41A 2oa1A-4my5A:
undetectable		 2oa1A-4my5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 8 TYR A  84
SER A 233
HIS A 239
SER A 238
 None
 1.28A 2vmyA-4my5A:
26.4
2vmyB-4my5A:
26.2		 2vmyA-4my5A:
23.00
2vmyB-4my5A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 12 LEU A 382
VAL A 348
GLU A 377
THR A 374
ILE A 303
 None
 1.20A 2vn0A-4my5A:
undetectable		 2vn0A-4my5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 12 LEU A 120
VAL A 118
ASP A 205
VAL A 207
SER A 236
 None
 1.42A 2y00A-4my5A:
undetectable		 2y00A-4my5A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 11 LEU A 156
ILE A 171
PRO A 121
PRO A 123
THR A 144
 None
 1.31A 3bjwH-4my5A:
undetectable		 3bjwH-4my5A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		3 / 3 GLY A  99
GLY A 234
GLY A 247
 None
 0.40A 3bogD-4my5A:
undetectable		 3bogD-4my5A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 LEU A 235
ILE A  48
ALA A 277
THR A 283
 None
 1.08A 3mdrA-4my5A:
undetectable		 3mdrA-4my5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 12 ILE A 200
ALA A 166
ILE A 142
LEU A 156
VAL A 170
 None
 1.00A 3s3vA-4my5A:
undetectable		 3s3vA-4my5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 12 PHE A  42
PRO A  40
LEU A  35
ILE A 375
ALA A 320
 None
 1.30A 4a83A-4my5A:
undetectable		 4a83A-4my5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 8 TYR A 208
ILE A 171
ASN A 173
GLU A  39
 None
 1.07A 4a97D-4my5A:
undetectable		 4a97D-4my5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 7 TYR A 208
ILE A 171
ASN A 173
GLU A  39
 None
 1.14A 4a97H-4my5A:
undetectable		 4a97H-4my5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 10 ALA A  71
LEU A  72
GLY A  68
ALA A 289
MET A 292
 None
 1.18A 4fe1A-4my5A:
undetectable
4fe1J-4my5A:
undetectable		 4fe1A-4my5A:
19.55
4fe1J-4my5A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 12 GLU A 102
ILE A  98
GLY A 243
VAL A 274
ALA A 277
 None
 1.15A 4foxD-4my5A:
undetectable		 4foxD-4my5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 7 GLN A 258
THR A 256
LEU A  95
THR A 268
 None
 1.07A 4mbsA-4my5A:
undetectable		 4mbsA-4my5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 11 ALA A 100
THR A 101
ALA A 103
MET A 241
GLY A 243
 None
 1.10A 4qvwK-4my5A:
undetectable
4qvwL-4my5A:
undetectable		 4qvwK-4my5A:
17.97
4qvwL-4my5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 11 ALA A 100
THR A 101
ALA A 103
MET A 241
GLY A 243
 None
 1.10A 4qvwY-4my5A:
undetectable
4qvwZ-4my5A:
undetectable		 4qvwY-4my5A:
17.97
4qvwZ-4my5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 9 ALA A 100
THR A 101
ALA A 103
MET A 241
GLY A 243
 None
 1.11A 4qwuK-4my5A:
undetectable
4qwuL-4my5A:
undetectable		 4qwuK-4my5A:
17.97
4qwuL-4my5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 9 ALA A 100
THR A 101
ALA A 103
MET A 241
GLY A 243
 None
 1.15A 4qwuY-4my5A:
undetectable
4qwuZ-4my5A:
undetectable		 4qwuY-4my5A:
17.97
4qwuZ-4my5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 5 LEU A 104
VAL A 118
VAL A 135
TYR A 128
 None
 1.02A 4r7iA-4my5A:
undetectable		 4r7iA-4my5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 12 PHE A 250
LEU A 231
LEU A 235
ALA A 103
VAL A  80
 None
 1.01A 4wnwB-4my5A:
undetectable		 4wnwB-4my5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		3 / 3 MET A  18
ASP A 334
PHE A 338
 None
 0.75A 4xeyA-4my5A:
undetectable		 4xeyA-4my5A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		3 / 3 MET A  18
ASP A 334
PHE A 338
 None
 0.77A 4xeyB-4my5A:
undetectable		 4xeyB-4my5A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 7 ILE A 303
LEU A 382
ALA A 325
ILE A 323
 None
 0.78A 4y03A-4my5A:
undetectable		 4y03A-4my5A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 6 ASP A 318
PRO A 153
THR A 152
VAL A 150
 None
 0.92A 4yoaA-4my5A:
undetectable		 4yoaA-4my5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 9 GLN A 228
GLU A 193
PRO A 153
LEU A 156
ILE A 160
 None
 1.34A 5i73A-4my5A:
1.5		 5i73A-4my5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		5 / 11 GLY A  38
GLU A  39
SER A 236
ALA A 369
ASN A 177
 None
 1.21A 5x6yA-4my5A:
undetectable		 5x6yA-4my5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE
(Streptococcus
mutans) 		4 / 5 PHE A 350
VAL A 329
MET A 379
VAL A 348
 None
 1.11A 6ekzA-4my5A:
undetectable		 6ekzA-4my5A:
12.47